A5078942758- Antibiotic Resistance in Bacteria
- Genomics and Phylogenetic Studies
- Enterobacteriaceae and Cronobacter Research
- Bacterial Identification and Susceptibility Testing
- Vibrio bacteria research studies
- Bacteriophages and microbial interactions
- Malaria Research and Control
- Hepatitis B Virus Studies
- Microbial Metabolism and Applications
- Microbial Community Ecology and Physiology
- Burkholderia infections and melioidosis
- Escherichia coli research studies
- Bacterial biofilms and quorum sensing
- Chemical Looping and Thermochemical Processes
- Vector-borne infectious diseases
- Brucella: diagnosis, epidemiology, treatment
- Yersinia bacterium, plague, ectoparasites research
- Pharmaceutical and Antibiotic Environmental Impacts
- Mosquito-borne diseases and control
Institut Pasteur de Bangui
2022-2024
Institut Pasteur de Madagascar
2017-2022
Institut Pasteur
2018
Klebsiella pneumoniae (phylogroup Kp1), one of the most problematic pathogens associated with antibiotic resistance worldwide, is phylogenetically closely related to K. quasipneumoniae [subsp. (Kp2) and subsp. similipneumoniae (Kp4)], variicola (Kp3) two unnamed phylogroups (Kp5 Kp6). Together, Kp1 Kp6 make-up complex. Currently, can be reliably identified only based on gene (or genome) sequencing. Misidentification using standard laboratory methods common consequently, clinical significance...
Background: Klebsiella pneumoniae (hereafter, Kp) is a major public health threat responsible for high levels of multidrug resistant (MDR) human infections. Besides, Kp also causes severe infections in the community, especially Asia and Africa. Although most are caused by endogenous intestinal carriage, little known about prevalence microbiological characteristics asymptomatic attached risk factors including environmental sources exposure.Methods: Here, 911 pregnant women from communities...
Abstract Arthropod‐borne diseases are important causes of morbidity and mortality. The identification vector species relies mainly on morphological features and/or molecular biology tools. first method requires specific technical skills may result in misidentifications, the second is time‐consuming expensive. aim present study to assess usefulness accuracy matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry ( MALDI‐TOF MS) as a supplementary tool with which identify...
The present study aimed to perform a deep phenotypic and genotypic analysis of 15 clinical carbapenem-resistant Acinetobacter baumannii (CRAb) strains isolated in Madagascar between 2008 2016 from diverse sources. CRAb isolates collected the Clinical Biology Centre Institut Pasteur Madagascar, neonatal unit Antananarivo military hospital, intensive care units Mahajanga Androva Joseph Ravoahangy Andrianavalona (HJRA) hospitals were subjected susceptibility testing. Whole-genome sequencing...
To define characteristics of Klebsiella pneumoniae isolated from carriage and infections in mothers their neonates belonging to a paediatric cohort Madagascar.A total 2000 2001 were included. For each mother, vaginal stool samples collected at the birth. Additionally, upon suspicion infection, suspected infected body sites 121 neonates. Genomic sequences all K. used for phylogenetic analyses investigate genomic content antimicrobial resistance genes, virulence genes plasmid replicon...
Abstract Klebsiella pneumoniae can lead to a wide range of diseases including pneumonia, bloodstream and urinary tract infections. During short period pulmonary plague epidemic in October 2017 Madagascar, 12 K . isolates were identified ten sputum two buboes aspirate samples. These from patients suspected plague, without epidemiological relationships, but negative for Yersinia pestis culture. Data collected the national surveillance system. The characterized by antimicrobial susceptibility...
Abstract The bacterial pathogen Klebsiella pneumoniae comprises several phylogenetic groups (Kp1 to Kp7), two of which (Kp5 and Kp7) have no taxonomic status. Here we show that group Kp5 is closely related variicola (Kp3), with an average nucleotide identity (ANI) 96.4%, Kp7 has ANI 94.7% Kp1 ( K. sensu stricto ). Biochemical characteristics chromosomal beta-lactamase genes also distinguish from other taxa. We propose the names africanensis for (type strain, 200023 T ) subsp. tropicalensis 1266
Abstract Interpreting phenotypes of bla SHV alleles in Klebsiella pneumoniae genomes is complex. While all strains are expected to carry a chromosomal copy conferring resistance ampicillin, they may also mutations or additional plasmid-borne that have extended-spectrum β-lactamase (ESBL) activity and/or inhibitor (BLI) activity. In addition, the role individual mutations/amino acid changes not completely documented understood. This has led confusion literature and antimicrobial (AMR) gene...
Introduction Data regarding the acquisition of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) in neonates at community level are scarce low-income and middle-income countries (LMICs), where burden neonatal sepsis is high. Our study aims identifying quantifying role different routes ESBL-PE transmission for neonates, which still undefined LMICs. Methods analysis In a semirural Madagascar, 60 mothers their will be recruited delivery, during maternal stool sample...