A5043038996- Renal Transplantation Outcomes and Treatments
- Parasitic infections in humans and animals
- Parasitic Infections and Diagnostics
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Pharmacological Effects and Toxicity Studies
- Congenital Anomalies and Fetal Surgery
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Neurological Complications and Syndromes
- Organ Transplantation Techniques and Outcomes
- Blood disorders and treatments
- Parathyroid Disorders and Treatments
- Medical Imaging and Pathology Studies
- Renal and Vascular Pathologies
- Metabolism and Genetic Disorders
- Renal Diseases and Glomerulopathies
- Cytomegalovirus and herpesvirus research
- Amoebic Infections and Treatments
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Neurogenetic and Muscular Disorders Research
- Eosinophilic Disorders and Syndromes
- Systemic Sclerosis and Related Diseases
University Hospital Münster
2015-2025
Klinikum Leverkusen
2012-2024
University of Münster
2010-2023
RELX Group (United States)
2019
International Society of Nephrology
2019
Jena University Hospital
2018
Hochschule Düsseldorf University of Applied Sciences
2018
Walter de Gruyter (Germany)
2018
General Department of Preventive Medicine
2017
University of Cologne
2016
Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to cardiovascular disease. Left ventricular hypertrophy (LVH) an important mechanism in individuals with CKD. Elevated levels FGF23 have been linked greater risks LVH and mortality patients CKD, but whether these represent causal effects unknown. Here, we report elevated are independently associated large, racially diverse CKD cohort. caused pathological isolated rat cardiomyocytes via FGF...
Chronic kidney disease (CKD) has been associated with impaired host response and increased susceptibility to infections. Leukocyte recruitment during inflammation must be tightly regulated protect the against pathogens. FGF23 levels are in blood CKD, of this hormone have a variety adverse effects CKD patients. Here, we shown that impairs leukocyte into inflamed tissue defense mice humans. neutralization murine models restored defense. Intravital microscopy animals chronic failure showed...
The endothelial glycocalyx (eGC), a carbohydrate-rich layer lining the luminal side of endothelium, regulates vascular adhesiveness and permeability. Although central to pathophysiology barrier dysfunction in sepsis, damage has been generally understudied, part because aberrancy vitro preparations its degradation during tissue handling. aim this study was analyze inflammation-induced eGC on living cells by atomic-force microscopy (AFM) nanoindentation technique. AFM revealed existence mature...
In human alveolar echinococcosis (AE), benzimidazoles are given throughout life because they only parasitostatic. It has been a longstanding goal to limit treatment, and recent reports suggest that, in selected cases, may be parasitocidal. Previously, we showed that positron -emission tomography (PET) using [ 18 F]fluoro-deoxyglucose discriminates active from inactive lesions AE. We have now performed 3-year prospective study 23 patients conducted structured treatment interruption those...
To study the association between infection and faucet contamination in a surgical intensive care unit (SICU).Prospective cohort study.One SICU 12 peripheral wards.From 45 patients colonized or infected with P. aeruginosa, 87 positive isolates were collected.P. aeruginosa also was found 150 of 259 (58%) tap water samples taken from patient rooms.Clonal relationships established by random amplification polymorphic DNA-polymerase chain reaction. A long-time (144 wks) single specific genotype...
Summary Invasive aspergillosis (IA) is a considerable clinical problem in neutropenic patients with haematological malignancies but its diagnosis remains difficult. We prospectively evaluated LightCycler TM polymerase chain reaction (PCR) assay, nested‐PCR assay and galactomannan (GM) enzyme‐linked immunosorbent (ELISA) to validate their significance diagnosing IA. During 205 treatment episodes 165 from six centres, GM testing was performed at regular intervals. Positive results were...
Fluoroquinolone prophylaxis during neutropenia in patients with cancer has been associated decreased incidence of gram-negative bacteremia. Bacterial antimicrobial resistance is likely to cause a progressive lack efficacy fluoroquinolones, but no convincing evidence from clinicoepidemiologic observations proved this hypothesis.This prospective observational study assessed the impact discontinuing fluoroquinolone on incidences fever and bacteremia mortality among neutropenia, after...
Invasive aspergillosis (IA) is a life-threatening infection in severely immunocompromised patients, especially those receiving intensive chemotherapy or undergoing haematopoietic stem cell transplantation. As the clinical diagnosis of IA mostly based on biomarkers (galactomannan, β-d-glucan, PCR assays) indicating Aspergillus as underlying pathogen, effect antifungal treatment performance these parameters still controversial. We evaluated an Aspergillus-specific assay bronchoalveolar lavage...
The effective calcineurin inhibitor (CNI) tacrolimus (Tac) is an integral part of the standard immunosuppressive regimen after renal transplantation (RTx). However, as a potent CNI it has nephrotoxic potential leading to impaired function in some cases. Therefore, high clinical impact identify factors which can predict who endangered develop toxicity. We hypothesized that Tac metabolism rate expressed blood concentration normalized by dose (C/D ratio) such simple predictor. we analyzed C/D...
Tacrolimus (Tac) is a part of the standard immunosuppressive regimen after renal transplantation (RTx). However, its metabolism rate highly variable. A fast Tac rate, defined by blood trough concentration (C) divided daily dose (D), associated with inferior function RTx. Therefore, we hypothesize that impacts patient and graft survival We analyzed all patients who received RTx between January 2007 December 2012 were initially treated an containing (Prograf®), mycophenolate mofetil,...
ObjectivesWe investigated the prevalence of raltegravir resistance-associated mutations at baseline and their evolution during therapy in patients infected with different HIV-1 subtypes.
Central nervous system (CNS) invasive aspergillosis (IA) is a fatal complication in immunocompromised patients. Confirming the diagnosis rarely accomplished as procedures are impaired by neutropenia and low platelet count. Cerebrospinal fluid (CSF) cultures or galactomannan (GM) regularly yield negative results thus suggesting need for improving diagnostic procedures. Therefore performance of an established Aspergillus-specific nested polymerase chain reaction assay (PCR) CSF samples...
Information on parasite viability in alveolar echinococcosis (AE) cannot be obtained by conventional imaging techniques. We evaluated the glucose metabolism of AE lesions use [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) 12 inoperable patients. Eight patients showed either perilesional or focal enhancement ("hot spots"), whereas 4 had nonenhancing (metabolically inactive) lesions. With PET, necrotic parasitic and areas enhanced metabolic activity could clearly discriminated....