A5028451638- Cancer-related molecular mechanisms research
- Bone and Dental Protein Studies
- MicroRNA in disease regulation
- Blood Coagulation and Thrombosis Mechanisms
- RNA modifications and cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Platelet Disorders and Treatments
- Aortic Disease and Treatment Approaches
- RNA Research and Splicing
- Cardiovascular Syncope and Autonomic Disorders
- Anesthesia and Neurotoxicity Research
- MXene and MAX Phase Materials
- Advanced Computational Techniques and Applications
- High Altitude and Hypoxia
- Endoplasmic Reticulum Stress and Disease
- Genomics, phytochemicals, and oxidative stress
- Infective Endocarditis Diagnosis and Management
- Circular RNAs in diseases
- Advanced ceramic materials synthesis
- Fibroblast Growth Factor Research
- Advanced Image Fusion Techniques
- Visual Attention and Saliency Detection
- Renin-Angiotensin System Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Sulfur Compounds in Biology
Qingdao University
2020-2025
Qingdao Municipal Hospital
2020-2025
Zhengzhou University of Aeronautics
2022
Heilongjiang Academy of Sciences
2022
Harbin Medical University
2011-2020
First Affiliated Hospital of Harbin Medical University
2018-2020
University of Miami
2013-2017
Second Affiliated Hospital of Harbin Medical University
2011-2016
Activation of an osteogenic transcriptional program contributes to the initiation aortic calcification in atherosclerosis.The role microRNAs regulating is understudied.We tested hypothesis that miR-30e regulates bone marrow-derived mesenchymal stem cells (MSCs), smooth muscle (SMCs), and ApoE 2/2 mice. Methods resultsIn aortas wild-type mice, we found highly expressed medial SMCs.In old transcripts are down-regulated inverse relation markers Runx2, Opn, Igf2.In vitro, over-expression reduced...
Cardiac myocyte hypertrophy, the main compensatory response to chronic stress in heart often progresses a state of decompensation that can lead failure. Osteopontin (OPN) is an effector for extracellular signalling induces growth and fibrosis. Although increased OPN activity has been observed stressed myocytes fibroblasts, detailed long term effects blocking on remain poorly defined. Targeting cardiac protein by RNA aptamer may be beneficial tuning down pathologic signalling. We aimed...
Oral squamous cell carcinoma (OSCC), the subtype of head and neck cancers, is notorious for its high incidence death rate. The role long non-coding RNAs (lncRNAs) discovered to be significant canceration cancer progression. Long intergenic non-protein coding RNA 958 (LINC00958) as a carcinogene in multiple such gastric cancer, pancreatic glioma, but there has been no report about how LINC00958 functions OSCC. objective our study unfold function mechanism investigation on First, TCGA database...
BACKGROUND: Patients with severe aortic stenosis, undergoing transcatheter valve replacement (TAVR), are more likely to develop thrombotic complications. However, the definite mechanisms underlying hypercoagulation state remain unclear date. Our objectives were explore whether and how neutrophil extracellular traps (NETs) play a procoagulant role in patients after TAVR alone or percutaneous coronary intervention within 1 year further evaluate their interactions platelets endothelial cells....
Vascular remodeling, that contributes to cardiovascular diseases such as hypertension develops by anomalous proliferation and migration of vascular smooth muscle cells (VSMCs). Cortistatin (CST), a newly discovered biological peptide, has been acknowledged for its protective effects against diseases. Whether CST an inhibitory regulation role in angiotensin II (Ang II)-induced VSMCs what molecular mechanisms may participate the inhibition process are still unknown.VSMCs were divided into...
Abstract B 4 C ceramics were prepared by conventional hot pressing (HP) and oscillatory (HOP). The results show that at the temperature pressure studied here, main densification mechanism of HP is grain‐boundary sliding, whereas HOP plastic deformation caused dislocation gliding, indicating promoted material. hardness reaches 39.5 GPa, which much higher than sample HP. current study suggests promising for preparing high‐performance ceramics.
Essential hypertension (EH) patients suffer from paradoxically thrombotic rather than haemorrhagic, although the exact mechanism remains elusive. Our aim is to explore whether and how neutrophil extracellular traps (NETs) play procoagulant role in EH patients, as well evaluated NET releasing were triggered by inflammatory cytokines.The concentration of plasma NETs components detected ELISA. The morphology cells formation analysed using immunofluorescence. Procoagulant activity was clotting...
Sleep disorders (SDs) are usually associated with an increase in frequency of ventricular tachycardia (VT). However, the relationship between SDs and prevalence VT within first week acute myocardial infarction (AMI) remains unclear. This study aimed to evaluate their associations potential mechanisms.This structured questionnaire-based cross-sectional enrolled 303 patients AMI from a hospital northern China. Pittsburgh Quality Index (PSQI) was used determine sleep quality subjects. Heart...
In recent years, image generation technology has rapidly advanced, resulting in the creation of a vast array AI-generated images (AIGIs). However, quality these AIGIs is highly inconsistent, with low-quality severely impairing visual experience users. Due to widespread application AIGIs, assessment (AIGIQA), aimed at evaluating from perspective human perception, garnered increasing interest among scholars. Nonetheless, current research not yet fully explored this field. We have observed that...
Deformable image registration (DIR) is a fundamental task in radiotherapy, with existing methods often struggling to balance computational efficiency, accuracy, and speed effectively. We introduce novel DIR approach employing parametric 3D Gaussian control points achieving better tradeoff. It provides an explicit flexible representation for spatial deformation fields between volumetric medical images, producing displacement vector field (DVF) across all positions. The movement of individual...
Abstract Background The mechanism of thrombotic complications in patients with aortic stenosis (AS) is unknown. Our aim was to evaluate the levels phosphodiesterase (PS) blood cells, endothelial cells (ECs), and extracellular vesicles (EVs) its procoagulant activity (PCA) different degrees AS. Methods Exposed PS ECs EVs were analyzed by flow cytometry. PCA evaluated clotting time (CT), intrinsic factor Xa (FXa), extrinsic FXa, thrombin fibrin formation assays. We also inhibitory effects...
Recovering dense and uniformly distributed point clouds from sparse or noisy data remains a significant challenge. Recently, great progress has been made on these tasks, but usually at the cost of increasingly intricate modules complicated network architectures, leading to long inference time huge resource consumption. Instead, we embrace simplicity present simple yet efficient method for jointly upsampling cleaning clouds. Our leverages an off-the-shelf octree-based 3D U-Net (OUNet) with...
Objective: Osteopontin (OPN) expression increases in the heart during hypertrophy and failure aorta atherosclerosis. OPN KO mice were reported to have a reduced hypertrophic response after trans-aortic constriction (TAC), plaque burden on an APOE-/- background. We hypothesized that RNA aptamer targeting protein would effectively modulate responses TAC atherogenesis. Method Results: C57BL6 male subjected sham or surgeries. injected starting day1 with mutant aptamer. At 4wks, treatment...