A5100719227- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Traditional Chinese Medicine Analysis
- Radiomics and Machine Learning in Medical Imaging
- Cerebrovascular and Carotid Artery Diseases
- COVID-19 diagnosis using AI
- Ophthalmology and Eye Disorders
- Cell Adhesion Molecules Research
- Pituitary Gland Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Trigeminal Neuralgia and Treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Coronary Interventions and Diagnostics
- Congenital Anomalies and Fetal Surgery
- Intracranial Aneurysms: Treatment and Complications
- Cerebral Venous Sinus Thrombosis
- Medical Imaging Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Functional Brain Connectivity Studies
- Atherosclerosis and Cardiovascular Diseases
- Bacterial Infections and Vaccines
- Myasthenia Gravis and Thymoma
Qilu Hospital of Shandong University
2009-2025
State Key Laboratory for Innovation and Transformation of Luobing Theory
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Guangdong Provincial People's Hospital
2008-2024
Jinan University
2020-2024
Michigan Medicine
2018-2024
Second Affiliated Hospital of Guangzhou Medical University
2024
Fujian Medical University
2024
Guangzhou Medical University
2024
ShenZhen People’s Hospital
2020-2023
Motor control exercise (MCE) is effective in alleviating non-specific chronic low back pain (NCLBP). Neuro-imaging research warranted to explore the underlying neural mechanisms of MCE.
Competitive quantitative PCRs were used to examine the consequences of stereotactically injecting a highly attenuated herpes simplex virus type 1 mutant into rat brains. This virus, designated RR1CAT/RR2lacZ, was engineered so that coding sequences genes UL39 and UL40 specifying subunits viral ribonucleotide reductase replaced by chloramphenicol acetyltransferase (CAT) lacZ gene sequences, respectively. Stereotactic injection this hippocampal region brain resulted in localized infection....
Abstract Three-dimensional lung organoids (LOs) derived from pluripotent stem cells have the potential to enhance our understanding of disease mechanisms and enable novel therapeutic approaches in neonates with pulmonary disorders. We established a reproducible ex vivo model development using transgene-free human induced generated fetuses infants Bochdalek congenital diaphragmatic hernia (CDH), polygenic disorder associated fetal compression hypoplasia at birth. Molecular cellular...
Background and aims Acute myocardial infarction (AMI) is the leading cause of death in world. Therefore, early identification prognosis older patients with AMI are particularly urgent, better to improve treatment. This study aimed explore association between albumin changes AMI. Methods Outcomes included all-cause during hospitalization, cardiac death, gastrointestinal hemorrhage, nonfatal infarction, acute heart failure, severe arrhythmia. Multivariable-adjusted Cox regression analysis...
To evaluate the microstructural changes of orbital optic nerve in thyroid-associated ophthalmopathy (TAO) patients with or without dysthyroid neuropathy (DON) using diffusion tensor imaging (DTI) and investigate whether DTI can be used to detect DON.59 bilateral TAO (n= 23) DON (non-DON, n= 36) who underwent pretreatment were included 118 orbits analyzed. The clinical features all collected. parameters, including mean, axial, radial diffusivity (MD, AD, RD, respectively) fractional...
Abstract We propose a classification method using the radiomics features of CT chest images to identify patients with coronavirus disease 2019 (COVID-19) and other pneumonias. The two groups participants (90 COVID-19 who were confirmed as positive by nucleic acid test RT-PCR 90 pneumonias patients) collected, data manually drawn outline region interest (ROI) was used extract textural histogram ROI obtain vector from each sample. Then, we divided into independent radiomic cohorts for training...
Abstract The establishment of an abundant source autologous cardiac progenitor cells would represent a major advance toward eventual clinical translation regenerative medicine strategies in children with prenatally diagnosed congenital heart disease. In support this concept, we sought to examine whether functional, transgene-free human cardiomyocytes (CMs) potential for patient-specific and applications could be reliably generated following routine amniocentesis. Under institutional review...
Background The mechanism driving dysthyroid optic neuropathy (DON) is unclear. Diffusion‐tensor imaging (DTI) allows for noninvasively assessing the microstructure of entire visual pathway and may facilitate a better understanding DON. Purpose To assess microstructural changes whole to investigate potential trans‐synaptic damage（TSD） pathogenesis in DON with DTI. Study Type Cross‐sectional. Population Sixty‐four patients bilateral thyroid‐associated ophthalmopathy (TAO), 30 34 without DON,...
Background and purpose: Previous studies have shown that Hypoperfusion Intensity Ratio (HIR) derived from Perfusion Imaging (PWI) associated with collateral status in large-vessel occlusion (LVO) acute ischemic stroke (AIS) could predict the rate of flow, speed infarct growth, clinical outcome after endovascular treatment (EVT). We hypothesized HIR CT (CTP) imaging relatively accurately functional LVO AIS patients receiving different types treatment. Methods: data consecutive were...
This study aimed to analyze the effect of urate deposition (UD) on bone erosion and examine association between volume monosodium (MSU) crystals an improved score method, as measured in metatarsophalangeal (MTP) joints patients with gout. Fifty-six diagnosed gout using 2015 European League Against Rheumatism American College Rheumatology criteria were enrolled. MSU at each MTP joint was dual-energy computed tomography (DECT) images. The degree evaluated modified Sharp/van der Heijde (SvdH)...
Neisseria gonorrhoeae surface protein A (NspA) is a highly conserved gonococcal antigen. To explore the potential of NspA in vaccine development against gonorrhea, BALB/c mice were immunized with pcNspA containing gene from N. strain WHO-A via intramuscular (i.m.) injection, intranasal (i.n.) immunization, or intravaginal (i.vag.) immunization. Following last DNA boosted recombinant (rNspA). Enzyme-linked immunosorbent assays (ELISAs) indicated that all generated measurable NspA-specific IgG...
Patients with hepatitis B virus (HBV)-related cirrhosis (HBV-RC) and minimal hepatic encephalopathy (MHE) exhibit alterations in homotopic inter-hemispheric functional connectivity (FC) corpus callosum (CC) degeneration. However, the progression of dysconnectivity cirrhotic patients from no MHE (NMHE) to its association diseased-related cognitive impairment remain uncharacterized. We hypothesized that exists NMHE further deteriorates at stage, which is associated performance measured by...
Purpose To develop and evaluate an automatic segmentation method of arterial vessel walls plaques, which is beneficial for facilitating the morphological quantification in magnetic resonance wall imaging (MRVWI). Methods MRVWI images acquired from 124 patients with atherosclerotic plaques were included. A convolutional neural network-based deep learning model, namely VWISegNet, was used to extract features calculate category each pixel facilitate wall. Two-dimensional (2D) cross-sectional...
To determine the prognostic CT features in patients with untreated thymic epithelial tumors (TETs). Clinical data and imaging of 194 pathologically confirmed TETs were retrospectively reviewed. The subjects included 113 male 81 female between 15 78 years age, a mean age 53.8 years. outcomes categorized according to whether relapse, metastasis or death occurred within 3 after first diagnosis. Associations clinical determined using univariate multivariate logistic regression analyses, while...
Using histogram analysis of T2 values to detect early involvement extraocular muscles (EOMs) in patients with thyroid-associated ophthalmopathy (TAO). Five EOMs each orbit were analyzed for 45 TAO and 22 healthy controls (HCs). Patients' grouped into involved or normal-appearing (NAEOMs). Histogram parameters signal intensity ratios (SIRs) compared; receiver operating characteristic (ROC) curve was performed differentiate NAEOMs from HCs. 24 reassessed following immunosuppressive treatment....
Objective Prediction of therapy response to intravenous methylprednisolone pulses (ivMP) is crucial for thyroid-associated ophthalmopathy (TAO). Image histograms may offer sensitive imaging biomarkers effect prediction. This study aimed investigate whether pretherapeutic, multiparametric T2 relaxation time(T2RT) histogram features extraocular muscles (EOMs) can be used predict response. Materials and Methods Forty-five active moderate-severe TAO patients, who were treated with standard ivMP...
A common genetic risk factor for bipolar disorder is the CACNA1C gene, a gene also critical cardiac rhythm. The impact of mutations on patient rhythm unknown. Here we report electrophysiological implications associated in using induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs). Results indicate related mutation causes electrical impulse conduction slowing mediated by impaired intercellular coupling via connexin43 gap junctions. In vitro therapy to restore expression increased...
Objective . This study is aimed at comparing the image quality and diagnostic performance of mean apparent diffusion coefficient (ADC) lesion‐to‐spinal cord signal intensity ratio (LSR) derived from turbo spin‐echo diffusion‐weighted imaging (TSE‐DWI) echo‐planar imaging‐ (EPI‐) DWI in patients with a solitary pulmonary lesion (SPL). Methods 33 SPL underwent chest using EPI‐DWI TSE‐DWI b = 600 s/mm 2 free breathing. A comparison distortion (DR), signal‐to‐noise (SNR), contrast‐to‐noise (CNR)...
Prostate cancer is a heterogeneous disease with poor survival rate at late stage. In this report, dual targeting PET agent was developed to partially address the tumor heterogeneity issue. The heterodimer F-BCN-PSMA-NT designed target PSMA and neurotensin receptor1 (NTR1), both of which have demonstrated great potential in prostate management. synthesized through conjugation Glu-urea-lys(Ahx) (PSMA motif) NT20.3 (NTR1 symmetric trifunctional linker, bearing an azide group for further...
The cardiotonic pill (CP), consisting of a mixture Radix Salviae Miltiorrhizae, Notoginseng, and Borneolum Syntheticum, has been widely used in the prevention treatment cardiovascular disease. Adhesion molecules, including intercellular cell adhesion molecule-1 vascular molecule-1, are involved development vulnerable plaque. We investigated effect CP rabbit model plaque established by local transfection with p53 gene. Compared control group, rabbits showed significantly lower intima-media...