A5063333899- Phytochemistry Medicinal Plant Applications
- Microbial Natural Products and Biosynthesis
- Essential Oils and Antimicrobial Activity
- Marine Sponges and Natural Products
- Phytochemistry and Bioactivity Studies
- Phytochemistry and Biological Activities
- Ethnobotanical and Medicinal Plants Studies
- Natural product bioactivities and synthesis
- Allelopathy and phytotoxic interactions
- Enzyme Production and Characterization
- Parasites and Host Interactions
- Helminth infection and control
- Phytochemistry and Bioactive Compounds
- Advanced Drug Delivery Systems
- Plant Diversity and Evolution
- Plant biochemistry and biosynthesis
- Wound Healing and Treatments
- Plant-Derived Bioactive Compounds
- Bee Products Chemical Analysis
- Coral and Marine Ecosystems Studies
- Advancements in Transdermal Drug Delivery
- Phytochemicals and Antioxidant Activities
- Botanical Studies and Applications
- Polymer-Based Agricultural Enhancements
- Natural Antidiabetic Agents Studies
Universidade de São Paulo
2018-2024
Universidade Estadual Paulista (Unesp)
2013-2023
Instituto de Botânica
2018-2023
Centro Universitário de Araraquara
2018
Large segments of the Brazilian population still suffer from malnutrition and diet-related illnesses. In contrast, many native fruits have biodiversity are underexploited sources bioactive compounds unknown to consumers. The phytochemical composition nine underexplored was determined. Carotenoids anthocyanins were identified quantified by high performance liquid chromatography-photodiode array-tandem mass spectrometry (HPLC-PDA-MS/MS), phenolic iridoids flow injection...
Resorting to a One Strain Many Compounds (OSMAC) approach, the marine Streptomyces sp. BRB081 strain was grown in six different media settings over 1, 2, 3 or 7 days. Extractions of mycelium and broth were conducted separately for each cultivation period by sonication using methanol/acetone 1:1 agitation with ethyl acetate, respectively. All acetate crude extracts analysed HPLC-MS/MS data treatment performed through GNPS platform MZmine 2 software. In parallel, genome sequenced, assembled...
The organic pollutants promote significant risks to both human health and environmental sustainability. These compounds have seen a dramatic increase in diversity quantity, infiltrating bodies of water, marine environments, living organisms. Some factors contribute pollutant emissions, such as road traffic industrial activities it leads spatiotemporal variability. Between the pollutants, Trace Organic Contaminants (TrOCs), which comprise diverse range chemicals, pharmaceutical residues,...
Helminth infections represent a serious problem for the production of small ruminants that is currently aggravated by resistance to anthelmintic products and has induced search control alternatives, such as natural products. In this study, extracts Turnera ulmifolia L. (leaves roots), Parkia platycephala Benth. seeds) Dimorphandra gardneriana Tul. bark), which have been cited in ethnoveterinary studies selected naturally goats cerrado (Brazilian savanna), were tested vitro against Haemonchus...
Lafoensia pacari A. St.-Hil., (Lythraceae) is a native tree of Brazilian Cerrado and commonly known in Brazil as "mangava-brava". Its leaves are used folk medicine wound healing, cutaneous mycoses, the treatment gastritis ulcers.The present study was designed to evaluate healing activity mechanism action hydroethanolic extract St.-Hil. (HELp), advance its chemical profiling.HELp prepared by maceration 70% solution (1:10, w/v). The phytochemical analyses were investigated using colorimetry...
Rocas Atoll is a unique environment in the equatorial Atlantic Ocean, hosting large number of endemic species, however, studies on chemical diversity emerging from this biota are rather scarce. Therefore, present work aims to assess metabolomic and pharmacological potential microbiota Atoll. A total 76 bacteria were isolated cultured liquid culture media obtain crude extracts. About one third (34%) these extracts recognized as cytotoxic against human colon adenocarcinoma HCT-116 cell line....
:Machaerium hirtum (Vell.) Stellfeld (Fabaceae) known in Brazil as "jacaranda de espinho" or "espinheira santa nativa" is a medicinal plant commonly used folk medicine to treat ulcers, cough and diarrhea. This study aimed investigate the anti-inflammatory antinociceptive effects of hydroalcoholic extracts from M. twig (HEMh) using vivo experimental models nociception through involvement transient receptor potential channels, acid-sensing ion channel (ASIC), nitrergic, opioidergic,...
Terminalia argentea Mart. (Combretaceae), known mainly as "capitão", is a native tree, not endemic, that occurs in the Amazon, Caatinga, Cerrado and Atlantic Forest Brazil. Leaf infusion popularly mentioned by riverine communities inhabit microregion of Northern Araguaia (Mato Grosso, Brazil) for treatment gastric ulcer, bronchitis haemorrhage. Considering wide medicinal use, lack studies evaluate safety use scarcity phytochemical T. leaves, this work was carried out with objective...
Secretory ducts have been reported for more than 50 families of vascular plants among primary and secondary tissues. A priori, all a plant are the same type, only slight variations in concentration their compounds few species. However, two types secretion were observed tissues Kielmeyera appariciana, leading us to investigate possible influence duct origins on structure metabolism this gland. appariciana has cortex pith phloem. Both composed uniseriate epithelium surrounded by sheath lumen...
Machaerium hirtum (Vell.) Stellfeld (M.hirtum) is a plant known as 'jacarandá-bico-de-pato' whose bark commonly used against diarrhea, cough and cancer. The aim of this study was to phytochemically characterise the hydroethanolic extract plant, investigate its antimutagenic activities using Ames test evaluate effects on cell viability, genomic instability, gene expression protection in human hepatocellular carcinoma cells (HepG2). Antimutagenic activity assessed by simultaneous pre-...
Abstract Objectives This study was carried out to evaluate the effects of flavonoids present in leaves Passiflora edulis fruit on complications induced by diabetes rats. Methods The extract P. leaf obtained 70% ethanol maceration. From dry extract, fractions were consecutive liquid–liquid partition with hexane, ethyl acetate and n-butanol. content isoorientin n-butanol determined ultra-performance liquid chromatography coupled electrospray triple quadrupole ionization (TQD) analysis tandem...
Three endophytic fungi isolated from
Ipomoea imperati is widely used in tropical areas to treat several pathological conditions. The effect of this plant against parasitic species has not been investigated even being for purpose the Brazilian northeastern. This study aimed evaluate anthelmintic and acaricide potential a hydroethanolic extract I. leaves stolons. stolons were crushed subjected maceration ethanol 70% (v/v), after which solvent was removed using rotary evaporator. chromatographic profile obtained by UV Spectrum...
O emprego de plantas medicinais refere-se a uma prática milenar, seja na medicina alternativa para cura diversas doenças, ou como método abortivo. No entanto, população em geral desconhece os grandes riscos que cometem. Neste sentido este trabalho teve objetivo avaliar o índice consumo por mulheres Unidade Básica Saúde (UBS), tentativa identificar quais as espécies mais frequentemente ingeridas inclusive período gestacional. Através um questionário caráter explorativo com 48 observou-se...
The analysis by HPLC-PDA of the hydroalcoholic extract leaves M. eriocarpum together with injection fractions containing already identified metabolites allowed detection at least 5 flavonoids, which two are derived from apigenin and three luteolin. After isolating larger amounts isovitexin (I), assays were performed to evaluate allelopathic activity crude extract. results show that initial inhibition indexes very similar those observed in treatments F17 (Fraction enriched isovitexin) F18...
Artemether (ART) and lumefantrine (LUM) are the gold standard antimalarial drugs used for treatment of malaria in children pregnant women. Typically, ART LUM delivered orally form a combined tablet, however, appropriateness this route administration these is questionable due to poor absorption therefore bioavailability observed unless administered alongside lipid-rich foods. Transdermal drug delivery patch-type system has been identified as viable alternative conventional tablet-based...
Jacaranda decurrens Cham., known as carobinha, is prevalent in the Cerrado biome and presents popular use treatment of dermatological diseases. The present study aimed to investigate healing action topical formulation Cham. (FtEHJ) mice cutaneous lesions.Phytochemical analysis J. hydroalcoholic extract was carried out by using HPLC-PDA-ESI-MS FIA-ESI-IT-MSn. Swiss were treated topically with base (FtB) or Fibrinase® ointment FtEHJ (15 mg/g; 50 mg/Kg). At end periods, inflammatory cytokines...