A5046641280- Pain Mechanisms and Treatments
- Essential Oils and Antimicrobial Activity
- Nerve injury and regeneration
- Ethnobotanical and Medicinal Plants Studies
- Ion Channels and Receptors
- Bee Products Chemical Analysis
- Pharmacological Effects of Natural Compounds
- Phytochemistry Medicinal Plant Applications
- Phytochemistry and Biological Activities
- Neuropeptides and Animal Physiology
- Venomous Animal Envenomation and Studies
- Laser Applications in Dentistry and Medicine
- Tendon Structure and Treatment
- Inflammatory mediators and NSAID effects
- Morinda citrifolia extract uses
- Neurobiology and Insect Physiology Research
- Biochemical and Structural Characterization
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bone and Joint Diseases
- Antioxidant Activity and Oxidative Stress
- Sleep and Wakefulness Research
- Phytochemistry and Bioactivity Studies
- Rabies epidemiology and control
- Knee injuries and reconstruction techniques
- Periodontal Regeneration and Treatments
Universidade Estadual de Campinas (UNICAMP)
2017-2024
Universidade Estadual Paulista (Unesp)
2008-2017
Around 20,000 snakebites are reported annually in Brazil and 90% of them inflicted by species the genus Bothrops. Intravenous administration antibothropic antivenom neutralizes systemic actions, but it is little effect on reversal local symptoms often induces adverse reactions, a context that drives search for complementary treatments snakebite accidents. Vegetable extracts with range antiophidian activities constitute an excellent alternative. In this study, we investigated anti-hemorrhagic...
Abstract Several recent studies have established the efficacy of photobiomodulation therapy (PBMT) in painful clinical conditions. Diabetic neuropathy (DN) can be related to activating mitogen-activated protein kinases (MAPK), such as p38, peripheral nerve. MAPK pathway is activated response extracellular stimuli, including interleukins TNF-α and IL-1β. We verified pain relief potential PBMT streptozotocin (STZ)-induced diabetic neuropathic rats its influence on regulation calcium (Ca 2+ )...
Davilla elliptica and nitida are species commonly found in the Brazilian Cerrado biome.Based on ethnopharmacological phytochemical analyses, methanolic extracts from leaves of (EDE) (EDN) were evaluated for their anti-ulcer, anti-inflammatory, immunological anti-Helicobacter pylori activities.The gastroprotective action both was rodent experimental models (HCl/ethanol, ethanol or NSAID). We also anti-inflammatory (carrageenin-induced rat hind paw edema), immunomodulatory (murine peritoneal...
Qualea parviflora Mart. is a medicinal species commonly found in the Brazilian Cerrado biome.Based on ethnopharmacological data, methanolic extract from (QP) bark was evaluated for its antiulcer, analgesic, anti-hemorrhagic, mutagenic and anti-Helicobacter pylori activities.The gastroprotective action of rodent experimental models (HCl/ethanol, ethanol or NSAID). We also effect (Ames assay), pylori, anti-hemorrhagic action, analgesic inflammatory effects (hot-plate test carrageenin-induced...
The mechanism underlying the role of tumor necrosis factor alpha (TNF-α) in development inflammatory hyperalgesia has been extensively studied, mainly TNF-α release pro-inflammatory cytokines. current concept relies fact that stimulates cascade other cytokines, such as IL-1β, IL-6, and IL-8 (CINC-1 rats), triggering final mediator prostaglandin E2 (PGE2 ) sympathetic amines directly sensitize nociceptors. However, this may not be sole involved blockade synthesis by thalidomide prevents...
:Machaerium hirtum (Vell.) Stellfeld (Fabaceae) known in Brazil as "jacaranda de espinho" or "espinheira santa nativa" is a medicinal plant commonly used folk medicine to treat ulcers, cough and diarrhea. This study aimed investigate the anti-inflammatory antinociceptive effects of hydroalcoholic extracts from M. twig (HEMh) using vivo experimental models nociception through involvement transient receptor potential channels, acid-sensing ion channel (ASIC), nitrergic, opioidergic,...
Background: Pannexin1 (Panx1) is a membrane channel expressed in different cells of the nervous system and involved several pathological conditions, including pain inflammation. At central system, role Panx1 already well-established. However, periphery, there lack information regarding participation neuronal sensitization. The dorsal root ganglion (DRG) critical structure for processing modulation. For this reason, understanding molecular mechanism DRG associated with hypersensitivity has...
Arrabidaea brachypoda (DC) Bureau is a medicinal plant found in Brazil. Known as "cipó-una", it popularly used natural therapeutic agent against pain and inflammation. This study evaluated the chemical composition antinociceptive activity of dichloromethane fraction from roots A. (DEAB) its mechanism action. The was characterized by high-performance liquid chromatography, this composed only dimeric flavonoids. effect formalin hot plate tests after oral administration (10-100 mg/kg) male...
Inflammation and haemorrhage are the main characteristics of tissue injury in botropic envenomation. Although some studies have shown that anti-venom prevents systemic reactions, it is not efficient preventing at site bite. Therefore, this work was undertaken to investigate anti-inflammatory effects methanolic extract fractions from D. elliptica evaluate role matrix metalloproteinases (MMPs) process. Effects were evaluated using a carrageenan-induced paw oedema model rats, leukocyte rolling...
Abstract Temporomandibular disorder (TMD) is a common painful condition of the temporomandibular joint (TMJ) and associated structures. Stress significant risk factor for developing this that predominantly affects women. This study aimed to test hypothesis stress increases TMJ pain by facilitating inflammatory mechanisms in female male rats. To hypothesis, we evaluated carrageenan‐induced expression pro‐inflammatory cytokines migration cells formalin‐induced nociception rats submitted...
Abstract Platelet-rich plasma (PRP) is a biological blood-derived therapeutic that releases several proteins in injured tissue, regulating the inflammatory process and triggering tissue anabolism. Outside of central nervous system (CNS), these platelets represent major source brain-derived neurotrophic factor (BDNF). The associated anti-inflammatory, antiapoptotic, antioxidant properties this neurotrophin could have potential applicability applied pathophysiology osteoarthritis (OA). In...
We evaluated the antinociceptive action of a methanolic extract from R. elaeocarpum (MeOH) and its mechanisms in rodent experimental models. The effect was by formalin method where male Swiss mice (n=5–8) received oral route saline, piroxicam (30mg/kg) or ME (250mg/kg). After 1 hour all animals 20µL solution 2.5% PBS at their hinder right paw. injection formalin, were observed during 5min (neurogenic phase) between 15–30min after infection (inflammatory phase). time spent licking injected...
Abstract Stress substantially increases the risk of developing painful temporomandibular disorders (TMDs) by influencing release endogenous catecholamines. Propranolol, an antagonist β‐adrenergic receptors, has shown potential in alleviating TMD‐associated pain, particularly when level catecholamines is elevated. The aim this study was to explore whether intra‐articular propranolol administration effective diminishing joint (TMJ) pain during repeated stress situations. Additionally, we...
Abstract Several recent studies have established the efficacy of photobiomodulation therapy (PBMT) in painful clinical conditions. Diabetic neuropathy (DN) can be related to activating mitogen-activated protein kinases (MAPK), such as p38, peripheral nerve. MAPK pathway is activated response extracellular stimuli, including interleukins TNF-α and IL-1β. We verified pain relief potential PBMT streptozotocin (STZ)-induced diabetic neuropathic rats its influence on regulation calcium (Ca 2+ )...