A5060326421- Helicobacter pylori-related gastroenterology studies
- Phytochemistry and Bioactive Compounds
- Pomegranate: compositions and health benefits
- Delphi Technique in Research
- Immune Response and Inflammation
- Natural product bioactivities and synthesis
- Ginger and Zingiberaceae research
- Papaya Research and Applications
- Biochemical Analysis and Sensing Techniques
- Sesquiterpenes and Asteraceae Studies
- Digestive system and related health
- Bee Products Chemical Analysis
- Essential Oils and Antimicrobial Activity
- Antimicrobial agents and applications
- Phytochemicals and Medicinal Plants
- Curcumin's Biomedical Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Herbal Medicine Research Studies
- Spinal Hematomas and Complications
- Phytoplasmas and Hemiptera pathogens
- Medicinal Plant Research
- Antimicrobial Peptides and Activities
- Plant Virus Research Studies
- Olfactory and Sensory Function Studies
- Phytochemistry and biological activity of medicinal plants
Universidade Estadual Paulista (Unesp)
2017-2025
Universidade Nove de Julho
2024
Osaka Prefecture University
2018
The University of Tokyo
2017
Chronic wounds have a significant impact on patients’ quality of life, necessitating the management pain, infection, bleeding, and emotional challenges. Debridement, which involves removal nonviable tissue, is crucial for promoting wound healing. In addition to surgical methods, cost‐effective alternatives such as local solutions ointments with biological properties been explored. The use natural compounds anti‐inflammatory, antibacterial, collagen‐synthesizing abilities holds promise This...
Background Obesity is a growing global epidemic associated with changes in the gut microenvironment and metabolic endotoxemia, which can exacerbate inflammatory processes. Citral (CT), monoterpene present essential oils, has been investigated for its anti-inflammatory, antioxidant, immunomodulatory properties. However, role modulating axis during alterations obesity remains unknown. In this study, we effects of CT on intestinal impairment induced by lipopolysaccharide (LPS) high-fat diet...
Obesity causes low-grade inflammation that results in the development of comorbidities. In people with obesity, exacerbation gastric lesion severity and delayed healing may aggravate mucosal lesions. Accordingly, we aimed to evaluate citral effects on eutrophic obese animals. C57Bl/6 male mice were divided into two groups: animals fed a standard diet (SD) or high-fat (HFD) for 12 weeks. Gastric ulcers induced using acetic acid (80%) both groups. Citral (25, 100, 300 mg/kg) was administered...
To determine whether the presence of bacterial flora contributes to ontogenic development macrophage function, ability macrophages release superoxide anion (O2-) in response stimulation with phorbol myristate acetate was compared conventional and germfree mice various ages after birth. One-week-old showed a very low level O2- by their macrophages, gradual increases were observed 2-, 3-, 4-week-old an age-dependent manner. Macrophages from always significantly lower same age; however,...
Backbone circularization of protein is a powerful method to improve its structural stability. In this paper, we presumed that tight connection leads much higher Therefore, designed circularized variants granulocyte-colony stimulating factor (G-CSF) with structurally optimized terminal connection. To estimate the appropriate length connection, surveyed Protein Data Bank find local structures as model for connecting segment. We set library composed "helix–loop–helix," subsequently selected...
The effect of large-scale synonymous substitutions in a small icosahedral, single-stranded RNA viral genome on virulence, titer, and protein evolution were analyzed. coat (CP) gene the Fny stain cucumber mosaic virus (CMV) was modified. We created four CP mutants which all codons nine amino acids 5' or 3' half replaced by either most frequently least used monocot plants. When dicot host (Nicotiana benthamiana) inoculated with these mutants, titers uninoculated symptomatic leaves decreased,...
Citral is a mixture of monoterpenes present in the essential oil several plants, such as Cymbopogon citratus and Zingiber officinale, possessing anti-inflammatory, anti-ulcerogenic, antipyretic actions. We investigated action citral on body temperature (Tb) inflammatory signaling eutrophic obese mice during Systemic Inflammation (SI) induced by Lipopolysaccharide (LPS). Thus, we assessed effect (25, 100, 300 mg/kg) ibuprofen LPS-induced SI Swiss male fed standard diet (SD) or high-fat (HFD)...
Chronic wounds have a significant impact on patients' quality of life, necessitating the management pain, infection, bleeding, and emotional challenges. Debridement, which involves removal nonviable tissue, is crucial for promoting wound healing. In addition to surgical methods, cost-effective alternatives such as local solutions ointments with biological properties been explored. The use natural compounds anti-inflammatory, antibacterial, collagen-synthesizing abilities holds promise This...
We investigated the ontogenic development of macrophage functions which are important in expression host defense against infection by Listeria monocytogenes. Macrophage functions, including accumulation response to local stimuli, chemotaxis vitro, and intracellular killing, as well number macrophages, were examined using mice 1, 2, 3, 4, 8 weeks old. The peritoneal macrophages was extremely low younger even when their body weights taken into consideration. infectious stimulus with viable...
Arrabidaea brachypoda (DC) Bureau is a medicinal plant found in Brazil. Known as "cipó-una", it popularly used natural therapeutic agent against pain and inflammation. This study evaluated the chemical composition antinociceptive activity of dichloromethane fraction from roots A. (DEAB) its mechanism action. The was characterized by high-performance liquid chromatography, this composed only dimeric flavonoids. effect formalin hot plate tests after oral administration (10-100 mg/kg) male...
Terminalia catappa L. (Combretaceae), known as "amendoeira da praia" in Brazil, has been recognized a medicinal plant folk medicine for the treatment of gastrointestinal disorders and other inflammatory conditions. The present study aimed to investigate preventive healing effects infusion leaves T. (ILTC) against gastric lesions caused by ischemia reperfusion (I/R) injury characterize its mechanism action mucosa rats. Different doses (30, 100, 300 mg/kg) ILTC were orally administered acute...
To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia (HEEP) leaves on gastric ulcer healing.In this rat study involving males, intact (cycling) females, and ovariectomized ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after induction. Body weight monitored throughout treatment period. At end treatment, rats euthanized following in vivo vitro investigations performed: macroscopic examination lesion area...
Eugenia punicifolia (Kunth) DC. (Myrtaceae), an Amazonian medicinal plant known as "pedra-ume-caá," is popularly used a natural remedy for inflammation, wounds, infections, diabetes, fever, and flu. Its anti-inflammatory, antinociceptive, gastroprotective effects have already been characterized. We evaluated the gastric healing effect of hydroalcoholic extract leaves E. (HEEP) in male female Wistar rats against nonsteroidal anti-inflammatory drugs (NSAIDs) ethanol.The HEEP on mucosa adult...
Obesity is a metabolic disorder characterized by the accumulation of fat in body that poses risk to individual's health. This leads development low-grade chronic inflammatory process and has been associated with diseases such as type 2 diabetes mellitus, cardiovascular neurodegenerative diseases. In adipose tissue, changes occur profile immune cells production adipokines can compromise insulin sensitivity. addition this characteristic obesity, there are also lipid caused dyslipidemia obese...
Obesity is one of the biggest public health problems in world, WHO estimates that more than 700 million adults will be obese by 2025. characterized an excessive accumulation fat can compromise health. Adipose tissue (AT) directly involved initiation and maintenance inflammatory response triggered obesity. This metabolic inflammation responsible for development diseases such as type 2 diabetes, cardiovascular non-alcoholic fatty liver disease. Finding adequate treatment obesity its...
The World Health Organization has been warning about the obesity epidemic affecting different age and socioeconomic groups. Studies have shown prevalence of diseases associated with obesity, such as gastroesophageal reflux disease (GERD). GERD is a chronic condition resulting from stomach contents, which causes tissue damage symptoms heartburn acid regurgitation. Due to local inflammation, defense cells are present in this process, they indicate an inflammatory process. An example presence...