A5031084120- Neuroscience and Neuropharmacology Research
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Sleep and Wakefulness Research
- Hypothalamic control of reproductive hormones
- Biochemical Analysis and Sensing Techniques
- Birth, Development, and Health
- Regulation of Appetite and Obesity
- Olfactory and Sensory Function Studies
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Cell Image Analysis Techniques
- Cardiac electrophysiology and arrhythmias
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Vestibular and auditory disorders
- Adipose Tissue and Metabolism
- Pain Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- 3D Printing in Biomedical Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
Universidade Estadual Paulista (Unesp)
2015-2024
Laboratoire Lorrain de Recherche en Informatique et ses Applications
2023
Universidad de Salamanca
2008-2013
Instituto de Estudios de Ciencias de la Salud de Castilla y León
2008-2013
Instituto de Neurociencias de Castilla y León
2010
Instituto de Neurociencias
2010
Clínica Las Condes
1993
Centro de Investigación en Materiales Avanzados
1990-1993
The acoustic startle reflex (ASR) is a survival mechanism of alarm, which rapidly alerts the organism to sudden loud auditory stimulus. In rats, primary ASR circuit encompasses three serially connected structures: cochlear root neurons (CRNs), in caudal pontine reticular nucleus (PnC), and motoneurons medulla spinal cord. It well-established that both CRNs PnC receive short-latency inputs mediate ASR. Here, we investigated anatomical origin functional role these using multidisciplinary...
Oropouche virus (OROV) is an emerging arbovirus in South and Central Americas with high spreading potential. OROV infection has been associated neurological complications genomic RNA detected cerebrospinal fluid from patients, suggesting its neuroinvasive Motivated by these findings, neurotropism neuropathogenesis of have investigated vivo murine models, which do not fully recapitulate the complexity human brain. Here we used slice cultures adult brains to investigate whether capable...
The inferior colliculus (IC) and the locus coeruleus (LC) are two midbrain nuclei that integrate multimodal information play a major role in novelty detection to elicit an orienting response. Despite reciprocal connections between these structures, projection pattern target areas of LC within subdivisions rat IC still unknown. Here, we used tract-tracing approaches combined with immunohistochemistry, densitometry, confocal microscopy (CM) analysis describe from IC. Biotinylated dextran amine...
Vav3 is a phosphorylation-dependent activator of Rho/Rac GTPases that has been implicated in hematopoietic, bone, cerebellar, and cardiovascular roles. Consistent with the latter function, Vav3-deficient mice develop hypertension, tachycardia, renocardiovascular dysfunctions. The cause those defects remains unknown as yet. Here, we show expressed GABAegic neurons ventrolateral medulla (VLM), brainstem area modulates respiratory rates and, via sympathetic efferents, large number physiological...
The zone of transition between the pretectum, derived from prosomere 1, and thalamus, 2, is structurally complex its understanding has been hampered by cytoarchitectural terminological confusion. Herein, using a battery complementary morphological approaches, including cytoarchitecture, myeloarchitecture expression molecular markers, we pinpoint features or combination that best characterize each nucleus pretectothalamic transitional rat. Our results reveal useful criteria to identify...
Abstract Although the melanin‐concentrating hormone ( MCH ) and its coding mRNA are predominantly found in tuberal hypothalamus, there is detectable synthesis of preoptic hypothalamus exclusively lactating dams, suggesting a participation alterations that take place after parturition. Also implicated dam physiology oxytocin, neurohormone released from posterior pituitary necessary for milk ejection. Because projection fields oxytocin‐immunoreactive (‐IR) neurones mediobasal overlap ‐IR...
The spinal cord is involved in local, ascending and descending neural pathways. Few studies analyzed the distribution of neuromediators laminae non-human primates along all segments. present study described classic primate Sapajus spp. through histochemical immunohistochemical methods. Nicotinamide adenine dinucleotide hydrogen phosphate-diaphorase (NADPH-d) method showed neuronal somata intermediolateral column (IML), central cervical nucleus (CCN), I, II, III, IV, V, VI, VII, VIII X,...
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS). MS and its animal model called experimental autoimmune encephalomyelitis (EAE) immunopathogenesis involve plethora immune cells whose activation releases variety proinflammatory mediators free radicals. Vitamin D3 (VitD) endowed with immunomodulatory antioxidant properties that we demonstrated to control EAE development. However, this protective effect triggered hypercalcemia. As such, compared...
Abstract Cochlear root neurons (CRNs) are involved in the acoustic startle reflex, which is widely used behavioral models of sensorimotor integration. A short‐latency component this auricular promotes pinna movements response to unexpected loud sounds. However, pathway reflex not well understood. We hypothesized that mediated by direct and indirect inputs from CRNs motoneurons responsible for movement, located medial subnucleus facial motor nucleus (Mot7). To assess whether there a...
Citral is a mixture of monoterpenes present in the essential oil several plants, such as Cymbopogon citratus and Zingiber officinale, possessing anti-inflammatory, anti-ulcerogenic, antipyretic actions. We investigated action citral on body temperature (Tb) inflammatory signaling eutrophic obese mice during Systemic Inflammation (SI) induced by Lipopolysaccharide (LPS). Thus, we assessed effect (25, 100, 300 mg/kg) ibuprofen LPS-induced SI Swiss male fed standard diet (SD) or high-fat (HFD)...
Ba2+ currents through voltage-dependent Ca channels and basal prolactin secretion were measured in single, cultured lactotropes by the combined use of whole cell patch-clamp recording reverse hemolytic plaque assay. Measurements area, a cumulative index relative amount released per unit time, indicate that can be grouped two main subpopulations differ secretory activity: small-plaque (SP) cells large-plaque (LP) cells. Analysis indicates both SP LP express types channels: low-threshold,...
Abstract The architecture and musculotopic organization of the facial motor nucleus in Cebus apella monkey (a New World primate) were investigated using histological techniques a multiple labelling strategy, which horseradish peroxidase‐conjugated neuroanatomical tracers (CTB‐HRP WGA‐HRP) fluorescent injected into individual muscles. was formed by multipolar motoneurons had an ovoid shape, with its rostrocaudal axis measuring on average 1875 µm. We divided four different subnuclei: medial,...
We have investigated the voltage-dependent Na channel activity of single lactotropes in pituitary cultures from adult male rats by recording whole cell Na+ currents under voltage clamp. Cells were identified their ability to secrete prolactin basal state as measured with reverse hemolytic plaque assay. found that cells elevated secretory rates [large-plaque (LP) lactotropes] present relatively large response depolarization, whereas secreting at low [small-plaque (SP) are small or not...
In order to identify ECG characteristics of overt midseptal accessory pathways (APs) predictive close proximity the AV conduction system we analyzed data from patients who underwent successful RF catheter ablation a mid‐septal AP, Mean patient age was 31 ± 16 years, and 13 were male. The 40° right anterior oblique view used divide area into 3 zones: 1 (anteriorportion); 2 (intermediate); (posterior portion). 12‐lead with regard delta wave polarity R/S transition in precordial leads. findings...
It has been shown that the lateral hypothalamus/perifornical area (LH/PFA) exerts an important role on arousal-state variations of central chemoreflex, but mechanisms underlie LH/PFA chemoreception are poorly understood. Here we asked whether glutamate inputs metabotropic receptors in modulate hypercapnic ventilatory response. We studied effects microinjection a receptor (mGluR) antagonist ((+)-α-Methyl-4-carboxyphenylglycine; MCPG; 100 mM) and selective Group II/III mGluR...