Clélia Akiko Hiruma-Lima

ORCID: 0000-0002-8645-3777
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About
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Research Areas
  • Essential Oils and Antimicrobial Activity
  • Helicobacter pylori-related gastroenterology studies
  • Phytochemistry and Bioactive Compounds
  • Phytochemistry Medicinal Plant Applications
  • Natural product bioactivities and synthesis
  • Ginger and Zingiberaceae research
  • Advances in Cucurbitaceae Research
  • Pharmacological Effects of Natural Compounds
  • Ethnobotanical and Medicinal Plants Studies
  • Bioactive Natural Diterpenoids Research
  • Phytochemistry and Biological Activities
  • Pomegranate: compositions and health benefits
  • Phytochemical Studies and Bioactivities
  • Phytochemicals and Antioxidant Activities
  • Natural Antidiabetic Agents Studies
  • Genomics, phytochemicals, and oxidative stress
  • Phytochemistry and biological activities of Ficus species
  • Ginkgo biloba and Cashew Applications
  • Alkaloids: synthesis and pharmacology
  • Phytochemistry and Bioactivity Studies
  • Biochemical Analysis and Sensing Techniques
  • Insect Pest Control Strategies
  • Sesquiterpenes and Asteraceae Studies
  • Piperaceae Chemical and Biological Studies
  • Traditional and Medicinal Uses of Annonaceae

Universidade Estadual Paulista (Unesp)
2015-2025

Universidade Federal de Alfenas
2021

University of Bari Aldo Moro
2005-2020

Neurology, Inc
2018

Instituto de Ciências Farmacêuticas
2017

Universidade Federal de Goiás
2017

Universidade Estadual de Campinas (UNICAMP)
1998-2017

Universidade Federal da Paraíba
1998-2017

Morpho (United States)
2017

Biolog (United States)
2017

Essential oil from Citrus aurantium and the monoterpene limonene are widely used flavoring agents that found in some common food items. This specie is also medicinally throughout world to treat gastritis gastric disorders. Therefore, biological assays were performed vivo on essential of C. (OEC) its majority compound (LIM) evaluate their effect mucosa. The OEC (250 mg/kg, p.o.) LIM (245 provided effective (99%) gastroprotection against lesions induced by absolute ethanol NSAID (non-steroidal...

10.1016/j.cbi.2009.04.006 article EN publisher-specific-oa Chemico-Biological Interactions 2009-05-05

Citrus lemon (CL) belongs to Rutaceae family and is popularly known in Brazil as limão siciliano. The phytochemical analysis of CL fruit bark essential oil showed two majority components, limonene (LIM) β-pinene (PIN). This study aimed evaluate the gastroprotective mechanism action from CL, LIM PIN ethanol- indomethacin-induced gastric ulcers its vitro anti-Helicobacter pylori activity. After ethanol-induced ulcer, ulcer area was measured stomachs were destined histology (HE PAS),...

10.1016/j.cbi.2010.09.031 article EN publisher-specific-oa Chemico-Biological Interactions 2010-10-09

This study was designed to determine the gastroprotective effect of a Mangifera indica leaf decoction (AD), on different experimental models in rodents. The administration AD up dose 5 g/kg (p.o.) did not produce any signs or symptoms toxicity treated animals, while significantly decreasing severity gastric damage induced by several models. Oral pre-treatment with (250, 500 1000 mg/kg) mice and rats lesions HCl/ethanol, absolute ethanol, non-steroidal anti-inflammatory drug (NSAID)...

10.3390/molecules14031098 article EN cc-by Molecules 2009-03-10

In order to determine the potential of Cerrado plants as sources antimicrobial activity, phytochemical screening ethanol extracts from Virola surinamensis, Qualea grandiflora, Alchornea castaneifolia, Hancornia speciosa and Curatella americana traditionally used in folk medicine are reported.

10.1002/ptr.2397 article EN Phytotherapy Research 2008-03-18

Hymenaea stigonocarpa Mart. ex Hayne (Fabaceae) is a medicinal species commonly found in the Brazilian savannah. The stem bark of this plant, popularly known as "jatobá-do-cerrado", widely used tea form to treat gastric pain, ulcers, diarrhoea and inflammation, whereas its fruits pulp edible.The aim study was investigate antidiarrheal anti-ulcer effects methanolic extract derived from (MHs) diet with fruit H. stigonocarpa.The action MHs measured against intestinal motility induced by castor...

10.1016/j.jep.2012.06.001 article EN publisher-specific-oa Journal of Ethnopharmacology 2012-06-27

Terminalia catappa L. (Combretaceae) is a medicinal plant listed as pharmacopeia vegetable from Caribbean to treat gastritis. The objective of this study was evaluate the gastroprotective and healing effect aqueous fraction (FrAq) obtained leaves determine antiulcer mechanism action in experimental rodent models its activity Helicobacter pylori. In rodents, FrAq challenged by different necrotizing agents, such absolute ethanol ischemia–reperfusion injury. assessed effects after seven 14 days...

10.1016/j.jep.2014.11.025 article EN publisher-specific-oa Journal of Ethnopharmacology 2014-11-24

Background Obesity is a growing global epidemic associated with changes in the gut microenvironment and metabolic endotoxemia, which can exacerbate inflammatory processes. Citral (CT), monoterpene present essential oils, has been investigated for its anti-inflammatory, antioxidant, immunomodulatory properties. However, role modulating axis during alterations obesity remains unknown. In this study, we effects of CT on intestinal impairment induced by lipopolysaccharide (LPS) high-fat diet...

10.3389/fphar.2025.1567217 article EN cc-by Frontiers in Pharmacology 2025-04-07
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