A5085042254- Essential Oils and Antimicrobial Activity
- Advanced Drug Delivery Systems
- Antifungal resistance and susceptibility
- Helicobacter pylori-related gastroenterology studies
- Antimicrobial Peptides and Activities
- Phytochemistry Medicinal Plant Applications
- Yersinia bacterium, plague, ectoparasites research
- Advancements in Transdermal Drug Delivery
- Phytochemistry and Bioactive Compounds
- Microbial Natural Products and Biosynthesis
- Natural product bioactivities and synthesis
- Antimicrobial agents and applications
- Plant Pathogens and Fungal Diseases
- Phytochemistry and Biological Activities
- Fungal Biology and Applications
- Drug Solubulity and Delivery Systems
- Chemical Synthesis and Analysis
- Ethnobotanical and Medicinal Plants Studies
- Marine Sponges and Natural Products
- Ocular Surface and Contact Lens
- Phytochemicals and Antioxidant Activities
- Bee Products Chemical Analysis
- Microbial Metabolites in Food Biotechnology
- Seaweed-derived Bioactive Compounds
- Pharmacological Effects of Natural Compounds
Universidade Estadual Paulista (Unesp)
2016-2025
Instituto de Ciências Farmacêuticas
1998-2023
Universidade de São Paulo
2003-2023
Centro Universitário de Araraquara
1991-2023
Background: The incidence of fungal infections, especially those caused by Candida yeasts, has increased over the last two decades. However, indicated therapy for control limitations. Hence, medicinal plants have emerged as an alternative in search new antifungal agents they present compounds, such essential oils, with important biological effects. Published data demonstrate pharmacological properties oil Cymbopogon nardus (L.) Rendle; these include anti-tumor, anti-nociceptive, and...
Abstract Coacervation via liquid-liquid phase separation provides an excellent opportunity to address the challenges of designing nanostructured biomaterials with multiple functionalities. Protein-polysaccharide coacervates, in particular, offer appealing strategy target biomaterial scaffolds, but these systems suffer from low mechanical and chemical stabilities protein-based condensates. Here we overcome limitations by transforming native proteins into amyloid fibrils demonstrate that...
Plant-based insecticides offer advantages such as negligible residual effects, reduced risks to both humans and the environment, immunity resistance issues that plague conventional chemicals. However, practical use of monoterpenes in insect control has been hampered by challenges including their poor solubility stability aqueous environments. In recent years, application nanotechnology-based formulations, specifically nanoemulsions, emerged a prospective strategy surmount these obstacles....
Citrus lemon (CL) belongs to Rutaceae family and is popularly known in Brazil as limão siciliano. The phytochemical analysis of CL fruit bark essential oil showed two majority components, limonene (LIM) β-pinene (PIN). This study aimed evaluate the gastroprotective mechanism action from CL, LIM PIN ethanol- indomethacin-induced gastric ulcers its vitro anti-Helicobacter pylori activity. After ethanol-induced ulcer, ulcer area was measured stomachs were destined histology (HE PAS),...
Abstract: Women often develop vaginal infections that are caused primarily by organisms of the genus Candida . The current treatments candidiasis usually involve azole-based antifungals, though fungal resistance to these compounds has become prevalent. Therefore, much attention been given molecules with antifungal properties from natural sources, such as curcumin (CUR). However, CUR poor solubility in aqueous solvents and oral bioavailability. This study attempted overcome this problem...
The number of bacterial strains that are resistant to multiple conventional antimicrobial agents is increasing. In this context, natural products have been widely used as a strategy treat diseases caused by bacteria. Infections Helicobacter pylori attracted attention because they directly related severe gastric medical conditions. Casearia sylvestris Swartz, popularly known guaçatonga, largely employed disorders in Brazilian folk medicine. This plant species has aroused much interest mainly...
Vulvovaginal candidiasis (VVC) is the most common infection caused by Candida albicans and greatly reduces quality of life women affected it. Due to ineffectiveness conventional treatments, there growing interest in research involving compounds natural origin. One such compound curcumin (CUR), which has been proven be effective against this microorganism. However, some CUR's physicochemical properties, especially its low aqueous solubility, make therapeutic application difficult. Thus,...
ABSTRACT It is well known that cationic antimicrobial peptides (cAMPs) are potential microbicidal agents for the increasing problem of resistance. However, physicochemical properties each peptide need to be optimized clinical use. To evaluate effects dimerization on structure and biological activity Ctx-Ha, we have synthesized monomeric three dimeric (Lys-branched) forms Ctx-Ha by solid-phase synthesis using a combination 9-fluorenylmethyloxycarbonyl (Fmoc) t -butoxycarbonyl (Boc) chemical...
Abstract: The genus Astronium (Anacardiaceae) includes species, such as fraxinifolium , graveolens and urundeuva which possess anti-inflammatory, anti-ulcerogenic, healing, antimicrobial properties. Nanostructured lipid systems are able to potentiate the action of plant extracts, reducing required dose side effects improving activity. This work aims evaluate a nanostructured system that was developed strategy improve anti- Candida albicans activity hydroethanolic extracts stems leaves from...
Terminalia catappa L. (Combretaceae) is a medicinal plant listed as pharmacopeia vegetable from Caribbean to treat gastritis. The objective of this study was evaluate the gastroprotective and healing effect aqueous fraction (FrAq) obtained leaves determine antiulcer mechanism action in experimental rodent models its activity Helicobacter pylori. In rodents, FrAq challenged by different necrotizing agents, such absolute ethanol ischemia–reperfusion injury. assessed effects after seven 14 days...
Herbal-loaded drug delivery nanotechnological systems have been extensively studied recently. The antimicrobial activity of medicinal plants has shown better pharmacological action when such are loaded into a system than they not loaded. Syngonanthus nitens Bong. (Rhul.) belongs to the Eriocaulaceae family and presents antiulcerogenic, antioxidant, antibacterial, antifungal activity. aim this study was evaluate (S. nitens) extract that (E) or (SE) liquid crystal precursor (S) for treatment...
The biological activities of a plant extract depend on complex sum individual properties including the antioxidant activity. Several protect against harmful action reactive oxygen species (ROS), and here we focused our attention relationship between tested properties. In this study, total flavonoid content as well antioxidant, antimicrobial, hemolytic cytotoxicity methanolic Leitothrix spiralis leaves were evaluated. showed 19.26% chemical characterization by HPLC-PAD confirmed presence...