The rising demand for plant-based meat analogues as alternatives to animal products has sparked interest in understanding the complex interplay between their structural and mechanical properties. ability manipulate processing parameters protein blend composition offers fundamental insights into texturization process holds economic sustainable implications food industry. Consequently, correlation properties is crucial achieving consumer satisfaction successful market penetration, providing...

Amyloid functional materials from amyloid fibril building blocks, produced in vitro amyloidogenic natural proteins or synthetic peptides, show diverse functionalities ranging environmental science and biomedicine, to nanotechnology biomaterials. However, sustainable affordable sources of remain the bottleneck for large-scale applications, date, interest remains essentially limited fundamental studies. Plant-derived would be an ideal source due their abundance low impact. Hereby oat globulin,...

Surfactant adsorption to fluid interfaces is ubiquitous in biological systems, industrial applications, and scientific fields. Herein, we unravel the impact of hydrophobic phase (air oil) role oil polarity on surfactants interfaces. We investigated anionic (sodium dodecyl sulfate), cationic (dodecyltrimethylammonium bromide), non-ionic (polyoxyethylene-(23)-monododecyl ether) at different interfaces, including air oils, with a wide range polarities. The surfactant-induced interfacial tension...

We introduce pyrogallol end-functionalized telechelic PEGs that are crosslinked with di- or trivalent ions to result in self-healing, adhesive hydrogels whose mechanical properties can be varied over an unprecedented range.

Cervical cancer is one of the most common cancers affecting women worldwide. There are an estimated 570.000 new cases cervical each year and conventional treatments can cause severe side effects. In this work, we developed a platform for vaginal administration lipophilic drugs treatment. We formulated mucoadhesive cubosomes delivery curcumin, drug treatment, to increase its bioavailability local absorption. This study tests use assesses their potential efficiency using CAM (chick embryo...

Abstract Coacervation via liquid-liquid phase separation provides an excellent opportunity to address the challenges of designing nanostructured biomaterials with multiple functionalities. Protein-polysaccharide coacervates, in particular, offer appealing strategy target biomaterial scaffolds, but these systems suffer from low mechanical and chemical stabilities protein-based condensates. Here we overcome limitations by transforming native proteins into amyloid fibrils demonstrate that...

Age-long ambition of medical scientists has always been advancement in healthcare and therapeutic medicine. Biomedical research indeed claims paramount importance nanomedicine drug delivery, the development biocompatible storage structures for delivering drugs stands at heart emerging scientific works. The delivery into human body is nevertheless a nontrivial challenging task, it often addressed by using amphiphilic compounds as nanosized vehicles. Pluronics belong to peculiar class...

Abstract Controlled polymerizations have enabled the production of nanostructured materials with different shapes, each exhibiting distinct properties. Despite importance shape, current morphological transformation strategies are limited in polymer scope, alter chemical structure, require high temperatures, and fairly tedious. Herein we present a rapid versatile strategy that operates at room temperature does not impair structure constituent polymers. By simply adding molecular transformer...

The determination of in situ structural information soft matter under flow is challenging, as it depends on many factors, such temperature, concentration, confinement, channel geometry, and type imposed flow. Here, we combine microfluidics scanning small-angle X-ray scattering (scanning-SAXS) to create a two-dimensional spatially resolved map, which represents quantitatively the variation molecular properties As application examples, mappings confined amyloid fibrils wormlike micelles into...

Abstract Protein‐based fibers are used by nature as high‐performance materials in a wide range of applications, including providing structural support, creating thermal insulation, and generating underwater adhesives. Such commonly generated through hierarchical self‐assembly process, where the molecular building blocks geometrically confined aligned along fiber axis to provide high level robustness. Here, this approach is mimicked using microfluidic spinning method enable precise control...

Virus-like particles (VLPs) are emerging as nanoscaffolds in a variety of biomedical applications including delivery vaccine antigens and cargo such mRNA to mucosal surfaces. These soft, colloidal, proteinaceous structures (capsids) nevertheless susceptible environmental stress factors. We cross-linked multiple capsid surface amino acid residues using homobifunctional polyethylene glycol tethers improve the persistence survival model stressors. Surface cross-linking enhanced stability VLPs...

Despite extensive research on the use of salts to enhance micellar growth, numerous questions remain regarding impact ionic exchange and molecular structure charge neutralization. This study looks into how certain cations (Na+, Ca2+, Mg2+) affect a cocamidopropyl betaine CAPB sodium dodecylbenzenesulfonate SDBS surfactant mixture, aiming toward applications in targeted delivery systems. The mixture consists zwitterionic surfactant, (CAPB), an anionic (SDBS), combined varying molar ratios at...

During the anisotropic growth from globular to wormlike micelles, basic interactions among distinct parts of surfactant monomer, its counterion, and additives are fundamental tune molecular self-assembly. We investigate addition sodium salicylate (NaSal) hexadecyltrimethylammonium chloride bromide (CTAC CTAB), 1-hexadecylpyridinium (CPyCl CPyBr), benzyldimethylhexadecylammonium (BDMC), which have same hydrophobic tail. Their potential enhance viscoelasticity by micellar upon salt was...

Abstract The origin of self‐winding mechanisms in plants’ tendrils has fascinated scientists for centuries and continues to inspire developments material science nanotechnology. Here, bioinspired water‐responsive wires that replicate these mechanisms, including the formation coils chiral perversions, are presented. A right‐handed gelatin matrix is loaded with rigid left‐handed amyloid fibrils roll–dry‐spun into which activation emerges from simultaneous bending twisting deformations. Wire a...

The nanostructural adaptation of bone is crucial for its biocompatibility with orthopedic implants. nanostructure also determines mechanical properties and performance. However, the bone's temporal spatial nanoadaptation around degrading implants remains largely unknown. Here, we present insights into this important by applying scanning electron microscopy, elemental analysis, small-angle X-ray scattering tensor tomography (SASTT). We extend novel SASTT reconstruction method provide a 3D...

TSPO is a ubiquitous transmembrane protein used as pharmacological marker in neuroimaging. The only known atomic structure of mammalian TSPOs comes from the solution NMR mouse (mTSPO) bound to PK11195 ligand and DPC surfactant environment. No available biomimetic environment without which strongly stiffens protein. We measured effect different amphiphilic environments on ligand-free mTSPO study its structure/function find optimal solubilization conditions. By replacing SDS surfactant, where...

Wormlike micellar aggregates formed from the mixture of ionic surfactants with aromatic additives result in solutions impressive viscoelastic properties. These properties are high interest for numerous industrial applications and often used as model systems soft matter physics. However, robust simple models tailoring response solution based on molecular structure employed additive required to fully exploit potential these systems. We address this shortcoming a modified packing parameter...

The recent advent of tensor tomography techniques has enabled tomographic investigations the 3D nanostructure organization biological and material science samples. These extended concept conventional X-ray by reconstructing not only a scalar value such as attenuation coefficient per voxel, but also set parameters that capture local anisotropy nanostructures within every voxel sample. Tensor data sets are intrinsically large each pixel projection is substituted scattering pattern, projections...

Cellulose nanocrystals (CNCs) are a promising bio-based material that has attracted significant attention in the fabrication of functional hybrid materials. The rod-like shape and negative surface charge CNCs enable their rich colloidal behavior, such as liquid crystalline phase hydrogel formation can be mediated by different additives. This study investigates effect depletion-induced attraction presence non-absorbing polyethylene glycol (PEG) molecular weights CNC aqueous dispersions, where...

Despite their distinctive secondary structure based on cross β-strands, amyloid fibrils (AF) are stable fibrous protein aggregates with features similar to collagen, one of the main components extracellular matrix, and thus constitute a potential scaffold for enhancing cell adhesion topical applications. Here, contribution AF skin bio-adhesivity aiming toward treatments is investigated. Liquid crystalline mesophase (LCM) phytantriol formulated, aqueous phase containing either water or...

In ionic surfactant micelles, basic interactions among distinct parts of monomers, their counterion, and additives are fundamental to tuning molecular self-assembly enhancing viscoelasticity. Here, we investigate the addition sodium salicylate (NaSal) hexadecyltrimethylammonium chloride bromide (CTAC CTAB) 1-hexadecylpyridinium (CPyCl CPyBr), which have counterions headgroup structures but same hydrophobic tail. Different contrasts obtained from small-angle neutron scattering (SANS), probes...

Abstract Self‐assembled materials such as lyotropic liquid crystals offer a wide variety of structures and applications by tuning the composition. Understanding behavior under flow induced alignment is wanted in order to tailor structure related properties. A method visualize anisotropy ordered systems situ dynamic conditions presented where flow‐induced nanostructural microfluidic channels observed scanning small angle X‐ray scattering hexagonal lamellar self‐assembled phases. In phase,...