A5021303857- Aerogels and thermal insulation
- Membrane Separation Technologies
- Supramolecular Self-Assembly in Materials
- Carbohydrate Chemistry and Synthesis
- Proteins in Food Systems
- Lysosomal Storage Disorders Research
- Electrostatics and Colloid Interactions
- Supercapacitor Materials and Fabrication
- Solar-Powered Water Purification Methods
- Material Dynamics and Properties
- Surfactants and Colloidal Systems
- Enzyme Catalysis and Immobilization
- Advanced Cellulose Research Studies
- Lipid Membrane Structure and Behavior
- Cell Adhesion Molecules Research
- Advanced Biosensing Techniques and Applications
- Click Chemistry and Applications
- Particle Dynamics in Fluid Flows
- Proteoglycans and glycosaminoglycans research
- Seaweed-derived Bioactive Compounds
- Angiogenesis and VEGF in Cancer
- Pickering emulsions and particle stabilization
- Fluid Dynamics and Mixing
- Microplastics and Plastic Pollution
- Alzheimer's disease research and treatments
ETH Zurich
2020-2025
The highly efficient utilization of bioresources and natural organic wastes has attracted great attention, due to the high-speed consumption shortage energy in modern society. Aerogels, attributable their outstanding properties potential applications diverse fields, have been a major topic innovative materials research last decades. While previously scientific community mainly focused on inorganic- plastic-based aerogels, recent years witnessed growing interest biomass-based counterparts. In...
Water contamination is a global threat due to its damaging effects on the environment and human health. pollution by microplastics (MPs), dissolved natural organic matter (NOM), other turbid particles ubiquitous in water treatment. Here, we introduce lysozyme amyloid fibrils as novel bio-flocculant explore their ability flocculate precipitate abovementioned undesired colloidal objects. Thanks positively charged surface very broad range of pH, show an excellent turbidity removal efficiency...
Amyloid functional materials from amyloid fibril building blocks, produced in vitro amyloidogenic natural proteins or synthetic peptides, show diverse functionalities ranging environmental science and biomedicine, to nanotechnology biomaterials. However, sustainable affordable sources of remain the bottleneck for large-scale applications, date, interest remains essentially limited fundamental studies. Plant-derived would be an ideal source due their abundance low impact. Hereby oat globulin,...
In the quest for a sustainable and circular economy, it is essential to explore environmentally friendly alternatives traditional petroleum-based materials. A promising pathway toward this goal lies in leveraging of biopolymers derived from food waste, such as proteins polysaccharides, develop advanced Here, we design versatile hybrid materials by hybridizing amyloid nanofibrils self-assembly whey, dairy byproduct, with chitin exfoliated two distinct allomorphs α-chitin β-chitin, extracted...
The inclusion of low-acetylated Gellan Gum and κ-carrageenan into amyloid fibril gels reinforces them mechanically, while preserving the surface functionality fibrils.
Enzyme immobilization is an efficient and cost-effective approach to recovering, stabilizing, enhancing enzyme catalytic properties. It a challenge, however, for coimmobilized multiple enzymes perform consecutive reactions without being inactivated under similar conditions. Here, we present facile platform using β-lactoglobulin amyloid fibril hydrogels. Two different hydrogels, loading either RuBisCO alone (hereby termed AFR*) or seven related the Calvin Cycle AF7E hydrogel), show efficiency...
Abstract Solar distillation is an appealing and facile technology for seawater desalination water purification, but constructing stable, environmentally‐friendly, cost‐effective solar evaporators often remain unfeasible. Here, amyloid hybrid aerogels are introduced universal renewable freshwater production by relying on the combination of sustainable materials energy, thus making process highly ecological virtually costless. Amyloid fibrils obtained from whey, a byproduct dairy industry,...
Mesh size is a crucial parameter that governs the behavior of gels made semiflexible polymers. We show average mesh amyloid fibril can be extracted from simple dynamic light scattering experiments. The data analysis performed combining theoretical descriptions nonergodicity and polymer dynamics. described method works in range concentrations where comparable with characteristic length scale associated probed wave-vector.
Niemann-Pick disease type C (NPC) is a severe disorder that characterized by intracellular transport abnormalities leading to cytoplasmic accumulation of lipids such as cholesterol and sphingolipids. The compound 2-hydroxypropyl-β-cyclodextrin (HPβCD) has high complexation capacity currently under clinical investigation for the NPC treatment. However, due its short blood half-life, doses are required produce therapeutic effect. In this work, stable polymerized HPβCD generated investigate...
Physical interactions between vascular endothelial growth factor (VEGF), a central player in blood cell biology, and fibronectin, major fibrillar protein of the extracellular matrix, are important determinants angiogenic activity health disease. Conditions signaling need for new vessel growth, such as hypoxia low pH, increase VEGF–fibronectin interactions. These can be further fine-tuned through changes availability VEGF-binding sites on regulated by conformational induced heparin heparan...
Reactive amyloid oligomers are responsible for cytotoxicity in pathologies and because of their unstable nature characterizing behavior is a challenge. The physics governing the self-assembly proteins crowded conditions extremely complex its comprehension, despite paramount relevance to understanding molecular mechanisms inside cells optimizing pharmaceutical processes, remains inconclusive. Here, we focus on oligomerization process self-crowded lysozyme aqueous solutions acidic conditions....
Photon correlation imaging unveiled gelation kinetics and stress relaxation in colloidal filamentous gels, set by perfusion of ions. We observed a linear-in-time evolution the front, ionic-strength dependant rearrangement dynamics.
Solar-Based Water Purification The cover art representing article number 2100309 by Raffaele Mezzenga and co-workers depicts an artist's view of black/white Janus aerogels floating over the surface imaginary lake surrounded cows producing milk proteins from which are made. These can be used for solar-based water purification, safe drinking at virtually no cost energy, besides freely available, unlimited solar energy.
Functional Amyloid Materials An oat-globulin amyloid aerogel sits on the awns of oat spikelet. This was fabricated by plant-based fibrils, made from seeds, as those shown in photo. As a sustainable material source with diverse functionalities, ensued amyloids were demonstrated ideal scaffold for templates such aerogels, hydrogels, water purification membranes and bioelectrodes. More details can be found article number 2104445 Raffaele Mezzenga co-workers.
Abstract Niemann-Pick Disease Type C (NPC) is a severe neurovisceral disorder that pathophysiologically characterized by intracellular transport abnormalities leading to cytoplasmic accumulation of lipids such as cholesterol and multiple sphingolipids, including sphingosine. The compound 2-hydroxypropyl-β-cyclodextrin (HPβCD) with high complexation capacity currently under clinical investigation for the treatment NPC. However, due its short blood half-life, doses are required produce...