A5063886259- Supramolecular Self-Assembly in Materials
- Membrane Separation and Gas Transport
- Hydrogels: synthesis, properties, applications
- Polymer Surface Interaction Studies
- Membrane Separation Technologies
- Nanopore and Nanochannel Transport Studies
- Per- and polyfluoroalkyl substances research
- Liquid Crystal Research Advancements
- Pickering emulsions and particle stabilization
- Advanced Nanomaterials in Catalysis
- Enzyme Catalysis and Immobilization
- Surface Modification and Superhydrophobicity
- Advanced Materials and Mechanics
- Carbon Dioxide Capture Technologies
- Carbohydrate Chemistry and Synthesis
- Advanced Glycation End Products research
- Phase Equilibria and Thermodynamics
- Intracerebral and Subarachnoid Hemorrhage Research
- Enzyme Production and Characterization
- Electrostatics and Colloid Interactions
- Microbial Metabolic Engineering and Bioproduction
- Proteins in Food Systems
- Lipid Membrane Structure and Behavior
- Surfactants and Colloidal Systems
- Alzheimer's disease research and treatments
ETH Zurich
2021-2025
Chinese Academy of Sciences
2017
University of Chinese Academy of Sciences
2017
Shanghai Advanced Research Institute
2017
Abstract Constructing effective antidotes to reduce global health impacts induced by alcohol prevalence is a challenging topic. Despite the positive effects observed with intravenous applications of natural enzyme complexes, their insufficient activities and complicated usage often result in accumulation toxic acetaldehyde, which raises important clinical concerns, highlighting pressing need for stable oral strategies. Here we present an solution detoxification employing biomimetic-nanozyme...
We introduce a green and efficient approach for removing per- polyfluoroalkyl substances (PFASs) based on the β-lactoglobulin amyloid fibril membrane.
Abstract Climate change caused by excessive CO 2 emissions constitutes an increasingly dire threat to human life. Reducing alone may not be sufficient address this issue, so that the development of emerging adsorbents for direct capture from air becomes essential. Here, we apply amyloid fibrils derived different food proteins as solid adsorbent support and develop aminosilane‐modified fibril‐templated aerogels applications. The results indicate sorption properties depend on mixing ratio...
Tailoring the hydrophilicity of solid surfaces with a strong affinity to water has been extensively explored in last 20 years, but studies have limited single function wettability. Here, multifunctional properties tailored surface films are extended from exhibiting superwettability facilitating biological activities. It is shown that amyloid fibrils can be universally coated onto various substrates, such as fabrics (non-woven organic masks), metal meshes, polyethersulfone (PES), glass, and...
Enzyme immobilization is an efficient and cost-effective approach to recovering, stabilizing, enhancing enzyme catalytic properties. It a challenge, however, for coimmobilized multiple enzymes perform consecutive reactions without being inactivated under similar conditions. Here, we present facile platform using β-lactoglobulin amyloid fibril hydrogels. Two different hydrogels, loading either RuBisCO alone (hereby termed AFR*) or seven related the Calvin Cycle AF7E hydrogel), show efficiency...
Amyloid fibrils have emerged as excellent templates and building blocks for the development of ordered functional materials with considerable potential in biomedical applications. Here, lysozyme amyloid (Lys-AFs) are employed situ synthesis ceria nanozymes (Lys-AFs-Ceria) ultrafine dimensions, an optimized Ce3+/Ce4+ ratio, uniform distribution on fibril surface, addressing challenges low catalytic efficiency high susceptibility to aggregation typical traditional methods. As a proof concept,...
Abstract The fibrillization of plant‐based proteins enhances their functionality, enabling potential applications in food and sustainable materials. Zein, a highly hydrophobic protein from corn, is versatile industrial ingredient, but its functionality limited to environments containing high levels organic solvents. This study aims develop protease‐assisted approach for synthesizing zein nanofibrils as functional building blocks, eliminating the need solvents conventional process. Through...
Rationally designing microstructures of soft hydrogels for specific biological functionalization is a challenge in tissue engineering applications. A novel and affordable hydrogel scaffold constructed here by incorporating polyphenol modules with lysozyme amyloid fibrils (Lys AFs) via non-covalent self-assembly. Embedded polyphenols not only trigger formation but also determine gel behavior regulating the gallol density complex ratio. The feasibility using polyphenol–Lys AF as biocompatible...
Abstract The helical periodicity and layered structure in cholesteric liquid crystals (CLCs) may be tuned to generate structural color according the Bragg's law of diffraction. A wide range natural‐based materials such as condensed DNA, collagen, chitin, cellulose, chiral biopolymers exhibit phases with left‐handed helixes ensued colors. Here, possibility using amyloid CLCs is reported prepare films iridescent reflection opposite handedness. Right‐handed assembled by fibrils are dried into...
Abstract Amyloid fibrils are biological rod‐like particles showing liquid–liquid crystalline phase separation into cholesteric phases through a complex behavior of nucleation, growth, and order‐order transitions. Yet, controlling the self‐assembly amyloids liquid crystals, particularly resulting helical periodicity, remains challenging. Here, novel system is introduced characterized based on hen egg white lysozyme (HEWL) amyloid results rationalized via combination experiments theoretical...
Neurodegenerative diseases are characterized by the presence of cross-β-sheet amyloid fibrils and a rich mesoscopic polymorphism, requiring noninvasive detection with high fidelity. Here, we introduce methodology that can probe via sensitive synthetic nanopore complex polymorphism an automated fast screening protocol. Statistically analyzing translocation events on two model systems derived from β-lactoglobulin lysozyme allows extracting cross-sectional configuration hydrated current block...