A5079593753- Plant-Derived Bioactive Compounds
- Phytochemistry Medicinal Plant Applications
- Essential Oils and Antimicrobial Activity
- Bee Products Chemical Analysis
- Composting and Vermicomposting Techniques
- Phytochemicals and Antioxidant Activities
- Sesquiterpenes and Asteraceae Studies
- Research on Leishmaniasis Studies
- Phytochemistry and Bioactivity Studies
- Botanical Research and Applications
- Antifungal resistance and susceptibility
- Moringa oleifera research and applications
- Plant Pathogens and Fungal Diseases
- Pharmacology and Obesity Treatment
- Phytochemical compounds biological activities
- Natural Antidiabetic Agents Studies
- Insect Pest Control Strategies
- Psychology and Mental Health
- Pharmacological Effects of Natural Compounds
- Waste Management and Recycling
- Phytochemistry and biological activity of medicinal plants
- Plant and animal studies
- Plant biochemistry and biosynthesis
- Nutritional Studies and Diet
- Hydrology and Watershed Management Studies
Instituto Federal do Amazonas
2025
Universidade Estadual Paulista (Unesp)
2015-2024
Instituto de Ciências Farmacêuticas
2023
Centro Universitário de Araraquara
2012-2022
Serviço Geológico do Brasil - CPRM
2017-2020
National Institute of Amazonian Research
2020
Universidade do Estado do Amazonas
2020
Universitat de Miguel Hernández d'Elx
2019
Technological Institute of Castilla y León
2019
Universitat Politècnica de Catalunya
2019
Background: The incidence of fungal infections, especially those caused by Candida yeasts, has increased over the last two decades. However, indicated therapy for control limitations. Hence, medicinal plants have emerged as an alternative in search new antifungal agents they present compounds, such essential oils, with important biological effects. Published data demonstrate pharmacological properties oil Cymbopogon nardus (L.) Rendle; these include anti-tumor, anti-nociceptive, and...
Abstract An EtOH extract of the leaves Casearia sylvestris afforded new clerodane diterpene, casearin X, together with known compounds casearins B, D, L, and O, caseargrewiin F. Casearin X degraded to corresponding dialdehyde when stored in CDCl 3 . The diterpenes isolated were cytotoxic human cancer cell lines, F being most active clerodane, second compound IC 50 values comparable positive control doxorubicin. All showed lower activities against normal cells than which might indicate a...
The number of bacterial strains that are resistant to multiple conventional antimicrobial agents is increasing. In this context, natural products have been widely used as a strategy treat diseases caused by bacteria. Infections Helicobacter pylori attracted attention because they directly related severe gastric medical conditions. Casearia sylvestris Swartz, popularly known guaçatonga, largely employed disorders in Brazilian folk medicine. This plant species has aroused much interest mainly...
Clerodane diterpenes have demonstrated cytotoxic, antiplasmodial and anti-ulcer properties. In the present work, we determined cytotoxic effect of casearin L (Cas L), O O) X X) (−)-hardwickiic acid isolated from Casearia sylvestris leaves, investigated underlying mechanisms involved in vitro cell death induced by Cas HL-60 leukemia cells (0.7, 1.5 3.0 μM). Cytotoxicity tests that was most active compound studied, showing greater effects against CEM lines (IC50 0.4 μM) human peripheral blood...
Leishmaniasis is a disease that affects millions of people and it an important public health problem. The drugs currently used for the treatment leishmaniasis present undesirable side effects low efficacy. In this study, we evaluated in vitro activity Melampodium divaricatum (MD-EO) Casearia sylvestris (CS-EO) essential oils (EO) against promastigote amastigote forms Leishmania amazonensis. Sesquiterpenes E-caryophyllene (56.0%), germacrene D (12.7%) bicyclogermacrene (9.2%) were identified...
The application of computer-aided drug discovery (CADD) approaches has enabled the new antimicrobial therapeutic agents in past. high prevalence methicillin-resistantStaphylococcus aureus(MRSA) strains promoted this pathogen to a high-priority for development. In sense, modern CADD techniques can be valuable tools search agents. We employed combination series machine learning (ML) select and evaluate potential compounds with antibacterial activity against methicillin-susceptible S. aureus...
Considering the reported activity of carvone in literature, this study aimed to evaluate antimicrobial, cytotoxic and chemopreventive activities (+)- (-)-carvone, (-)- hydroxydihydrocarvone α,β-epoxycarvone. (+)-Hydroxydihydrocarvone (HC+), (-)-hydroxydihydrocarvone (HC-) α,β-epoxycarvone (EP) were obtained by synthesis using (+)-carvone (C+) or (-)-carvone (C-) as precursors. The antifungal (MIC MFC) evaluated against Candida parapsilosis, C. tropicalis, krusei albicans antibacterial MBC)...
Abstract The biodiversity and productivity of the Amazon floodplain depend on nutrients organic matter transported with suspended sediments. Nevertheless, there are still fundamental unknowns about how hydrological rainfall variability influence sediment flux in River. To address this gap, we analyzed 3069 samples collected every 10 days during 1995–2014 at five gauging stations located main rivers. We have two distinct fractions sediments, fine (clay silt) coarse (sand), which followed...
The Amazon region has the largest hydrographic basin in world. rivers act as roads, and boats serve vehicles for transporting passengers cargo to large urban centers, municipalities, riverside communities, villages, settlements. River transportation system faces critical gaps due lack of land infrastructure certain areas, which makes essential commerce access isolated communities. This work proposes development a new hardware platform consisting system-in-package (SiP)—iMCP HTLRBL32L GPS,...
Introdução: O transporte aeromédico, originado na Guerra Franco-Prussiana de 1870, tem sido essencial no atendimento a vítimas trauma, oferecendo rapidez e eficiência em situações críticas. Objetivo: Mapear as evidências científicas refrentes aos aspectos gerais relacionados atendimentos prestados às trauma por meio aéreo. Metodologia: Trata-se uma revisão escopo, seguindo recomendações do Instituto Joanna Briggs Preferred Reporting Items for Systematic reviews and Meta-Analyses Extension...
In this study, was evaluated the chemical composition of a fraction from Syngonanthus nitens extract and its antimicrobial potential unloaded (Fr3) loaded (F9Fr3) into nanoemulsion (F9) composed cholesterol as oil phase (10%), polyoxyethylene 20-cetyl ether soy phosphatidylcholine (2:1) surfactant (20%), solution phosphate buffer (pH 7.4) plus chitosan polymer dispersion (0.25%) aqueous (70%) to use for VVC treatment. Phytochemical procedures showed that Fr3 is rich in luteolin, which...