A5029383809- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advancements in Transdermal Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- Phytochemistry Medicinal Plant Applications
- DNA and Nucleic Acid Chemistry
- Biosensors and Analytical Detection
- Polymer Surface Interaction Studies
- Plant-Derived Bioactive Compounds
- Nanoparticle-Based Drug Delivery
- Hydrogels: synthesis, properties, applications
- Surfactants and Colloidal Systems
- Porphyrin and Phthalocyanine Chemistry
- Silk-based biomaterials and applications
- Proteoglycans and glycosaminoglycans research
- Spectroscopy and Chemometric Analyses
- Microfluidic and Capillary Electrophoresis Applications
- Fungal Infections and Studies
- Protein Structure and Dynamics
- Pineapple and bromelain studies
- Dendrimers and Hyperbranched Polymers
- Dermatology and Skin Diseases
- Skin Protection and Aging
Universidade Estadual de Campinas (UNICAMP)
2018-2025
Terasaki Foundation
2023
Pontifícia Universidade Católica de Campinas
2020
Universidade do Vale do Paraíba
2013-2017
Can molecular dynamics simulations predict the mechanical behavior of protein complexes? decipher role domains unknown function in large macromolecular Here, we employ a wide-sampling computational approach to demonstrate that simulations, when carefully performed and combined with single-molecule atomic force spectroscopy experiments, can explain highly mechanostable complexes. As test case, studied previously unreported homologue from Ruminococcus flavefaciens called X-module-Dockerin...
The present work, involves the simulation of transport a vitamin C derivative, Ascorbyl Tetraisopalmitate (ATI), through human skin by molecular dynamics. Percutaneous absorption ATI molecule infundibulum, an important route into hair follicle skin, has been modeled and compared with stratum corneum membrane. comparative study was done using dynamics Martini force field. In single require more time to penetrate, data obtained suggested that high concentration accelerated process penetration....
Abstract Messenger RNA (mRNA) therapy is the intracellular delivery of mRNA to produce desired therapeutic proteins. Developing strategies for local still required where direct intra‐articular injections are inappropriate targeting a specific tissue. The efficiency depends on protecting nucleic acids against nuclease‐mediated degradation and safe site‐specific delivery. Herein, novel mRNA‐releasing matrices based RGD‐moiety‐rich gelatin methacryloyl (GelMA) microporous annealed particle...
Localized release of nucleic acid therapeutics is essential for many biomedical applications, including gene therapy, tissue engineering, and medical implant coatings. We applied the substrate-mediated transfection layer-by-layer (LbL) technique to achieve an efficient local delivery. In experiments presented herein, we embeded lipoplexes containing plasmid DNA encoding enhanced green fluorescent protein (pEGFP) within polyelectrolyte alginate-based microgels composed poly(allylamine...
Efficient delivery of nanometric vectors complexed with nanoparticles at a target tissue without spreading to other tissues is one the main challenges in gene therapy. One means overcome this problem confine such within microgels that can be placed released slowly and locally. Herein, conventional optical microscope coupled common smartphone was employed monitor microfluidic production monodisperse alginate containing as model for encapsulation vectors. Alginate (1.2%) exhibited an average...
In this paper, we studied the phenylalanine amino acid in different systems, it means, with solvent molecules as water, ammonia and urea, via density functional theory (DFT). These are present natural moisturizing factor (NMF) of skin that is found stratum corneum. The aim study improving understanding environment role its influences. Therefore, paper analyzed vibrational modes (and compared to FT-Raman FT-IR experimental values) electronic properties charge densities (HOMO LUMO). We also...
In this paper we investigated the Paracoccidoides brasiliensis fungus nanosensor by simulations of simple strand DNA grafting on gold nanoparticle. order to improve knowledge nanoparticle environment, addiction salt solution was studied at models proposed us. Nanoparticle and are represented economic validated us in paper. addition, influences evaluated adsorption bond energies calculations. This theoretical evaluation gives support experimental diagnostics techniques diseases.
O estrato córneo é a camada mais externa da pele, atua como uma forte barreira contra microrganismos, desidratação pele e permeação de fármacos. Deste modo, para que haja um aumento permeação, muitas vezes, faz-se necessária utilização promotores. Eles facilitam interação por meio mecanismos diminuem obstinação cutânea. Este trabalho utilizará simulação computacional prever do promotor propilenoglicol na dérmica. objetivo avaliar se existe no transporte ativos com menor danos bicamada...