A5034346006- Plant-Derived Bioactive Compounds
- Essential Oils and Antimicrobial Activity
- Antifungal resistance and susceptibility
- Phytochemical compounds biological activities
- Antimicrobial Peptides and Activities
- Research on Leishmaniasis Studies
- Pharmacology and Obesity Treatment
- Phytochemistry Medicinal Plant Applications
- Sesquiterpenes and Asteraceae Studies
- Natural Antidiabetic Agents Studies
- Insect Pest Control Strategies
- Historical Medical Research and Treatments
- Phenothiazines and Benzothiazines Synthesis and Activities
- Environmental Toxicology and Ecotoxicology
- Computational Drug Discovery Methods
- Plant biochemistry and biosynthesis
- Bioactive natural compounds
- Chemical synthesis and pharmacological studies
- Moringa oleifera research and applications
- Bee Products Chemical Analysis
- Coconut Research and Applications
- Plant chemical constituents analysis
- Phytochemistry and Bioactivity Studies
- Biological Stains and Phytochemicals
- Free Radicals and Antioxidants
Universidade Estadual Paulista (Unesp)
2017-2024
The number of bacterial strains that are resistant to multiple conventional antimicrobial agents is increasing. In this context, natural products have been widely used as a strategy treat diseases caused by bacteria. Infections Helicobacter pylori attracted attention because they directly related severe gastric medical conditions. Casearia sylvestris Swartz, popularly known guaçatonga, largely employed disorders in Brazilian folk medicine. This plant species has aroused much interest mainly...
Leishmaniasis is a disease that affects millions of people and it an important public health problem. The drugs currently used for the treatment leishmaniasis present undesirable side effects low efficacy. In this study, we evaluated in vitro activity Melampodium divaricatum (MD-EO) Casearia sylvestris (CS-EO) essential oils (EO) against promastigote amastigote forms Leishmania amazonensis. Sesquiterpenes E-caryophyllene (56.0%), germacrene D (12.7%) bicyclogermacrene (9.2%) were identified...
Natural latex from Hevea brasiliensis (Wild. ex A.Juss) Müll.Arg., Euphorbiaceae, showed angiogenic action and Casearia sylvestris Sw., Salicaceae, leaf derivatives presented anti-inflammatory wound healing activities. Therefore, an association of these effects was interesting for applications. The aims this study were the development membranes natural incorporated with C. (ethanolic extract, diterpene concentrated fraction casearin J), their chemical physical characterization, evaluation in...
Varronia curassavica Jacq. is a medicinal plant found in Brazil used as anti-inflammatory. Here, we investigated the vitro antioxidant activity of 70 % ethanol extract V. leaves on synthetic radicals (ABTS•+/DPPH•) and reactive oxygen species (O2•-, ROO•, HOCl/OCl-, H2O2), besides its cytotoxicity. The was characterized by UPLC-ESI-QToF-MSE annotated compounds were one hydroxybenzoic acid, five phenylpropanoids, three glycosylated quercetin derivatives, being main compound rosmarinic acid or...
Rationale Clerodane‐type diterpenes from Casearia species show important pharmacological activites such as antitumor, antimicrobial and anti‐inflamatory. There are several mass spectrometry (MS)‐based methods for identification of diterpenes; however, there is still a lack MS procedures capable providing characteristic fragmentation pathways rapid unambiguous elucidation casearin‐like compounds. Methods Casearin‐like compounds were investigated by electrospray ionization tandem (ESI‐MS/MS)....
Abstract Casearia sylvestris is an endemic tree of the Latin America that essential oil (EO) has anti‐inflammatory and gastroprotective actions. This study evaluates chemical composition EO from volatile fractions in natura , fresh, dried C. var. lingua leaves. For both varieties, leaves presented higher yield as compared to fresh The major components were ( E )‐caryophyllene, α ‐humulene, germacrene D, bicyclogermacrene, spathulenol, caryophyllene oxide, humulene epoxide II. In content...
Natural products have been largely explored as treatments for leishmaniasis, neglected diseases with few toxic therapeutic options, scaffolds the development of new drugs. Herein, derivatives from aerial parts Baccharis trimera (Less.) DC (extract and its fractions) were evaluated against Leishmania amazonensis macrophage cells. The ethyl acetate extract was fractionated by solid-phase extraction, resulting in eight fractions (F1-F8). Fractions F3-4 further separated into 149 subfractions;...
This study evaluated the potential of Baccharis trimera essential oil (EO) and its components in cancer therapy through application cytotoxicity cell death assays. Using gas chromatography analysis, major aerial parts were identified as (E)-caryophyllene (18.9%), bicyclogermacrene (15.6%), germacrene D (10.5%). (5.8 μg/mL) α-humulene (7.8 presented strong cytotoxic activity, while (11.5 caryophyllene oxide (> 100.0 showed moderate low activities, respectively, against MCF-7 lines. Against...
Abstract Oral preparations of Casearia sylvestris (guacatonga) are used as antacid, analgesic, anti-inflammatory, and antiulcerogenic medicines. The clerodane diterpenes casearin B caseargrewiin F major active compounds in vitro vivo. oral bioavailability metabolism were not previously investigated. We aimed to assess the stability physiological conditions their human liver microsomes. identified by UHPLC-QTOF-MS/MS quantified validated LC-MS methods. was assessed vitro. Both showed a fast...
Varronia curassavica displays anti-inflammatory, antiulcerogenic, and antioxidant activities. Herein, we employed new UHPLC -UV green chromatographic methods for the analysis of in vitro anti-inflammatory activities V. its embryotoxicity Zebrafish. Cordialin A, brickellin, artemetin were purified from ethanol (EtOH) extract Curassavica leaves identified using spectrometric techniques. In line with Green Analytical Chemistry principles, proposed involve use as organic modifier low mobile...
Phyllanthus niruri L. has been used in folk medicine to treat hepatitis, diabetes, urinary tract disorders, and renal calculi. Here, the chemical differences among its organs seasonal variability aerial parts were evaluated. The chromatographic profile gallic acid, corilagin, ellagic acid contents determined by ultrahigh performance liquid chromatography with photodiode array ultraviolet (UHPLC-PDA/UV) method, which showed adequate resolution a short analysis time. of corilagin leaf extract...
Schistosomiasis, a tropical disease caused by flatworms, may affect the liver, spleen, bladder, and intestine. Casearia sylvestris Swartz, medicinal plant, displays antiprotozoal, antimicrobial, antifungal, antiulcer activities. We have evaluated in vitro schistosomicidal activity of two C. varieties against Schistosoma mansoni adult worms at concentrations between 12.5 200 μg/mL. At 100 μg/mL, ethanolic var. leaf extract enriched casearin-like diterpenes eliminated % parasites after...
The Casearia sylvestris Sw. dried leaf essential oil (EO) contains sesquiterpenes as the main components. However, volatile components in natura leaves remain unknown. This study compares chemicals and EO of two C. populations from Atlantic Forest Cerrado. compounds were directly analysed by thermal desorption (TD) coupled to gas chromatography mass spectrometry (GC-MS); composition was determined GC-MS. All identified sesquiterpenes, major (E)-caryophyllene, bicyclogermacrene, ?-elemene,...
Abstract Infections caused by Candida strains increased, as well resistant to the most conventional antimicrobials. Thus, search for new natural sources of antimicrobials without adverse effects also increased. In this case, Astronium urundeuva Engl., a medicinal plant with several pharmacological activities, including antifungal activity, emerges source compounds. Here, we evaluated activity A. and its derivatives free or loaded into nanostructured lipid system, combination studies against...