A5036029742- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Antimicrobial Peptides and Activities
- Nail Diseases and Treatments
- Essential Oils and Antimicrobial Activity
- Plant Disease Resistance and Genetics
- Plant-Derived Bioactive Compounds
- Plant Pathogens and Fungal Diseases
- Protein Hydrolysis and Bioactive Peptides
- T-cell and Retrovirus Studies
- Coconut Research and Applications
- Studies on Chitinases and Chitosanases
- Invertebrate Immune Response Mechanisms
- Microplastics and Plastic Pollution
- Plant-Microbe Interactions and Immunity
- Phytochemistry Medicinal Plant Applications
- Phytochemistry and Biological Activities
- Aquaculture disease management and microbiota
- Biochemical and Structural Characterization
- Heat shock proteins research
- Pineapple and bromelain studies
- Birth, Development, and Health
- Antibiotic Resistance in Bacteria
- Apelin-related biomedical research
- Sesquiterpenes and Asteraceae Studies
Universidade Federal de Minas Gerais
2022-2024
Universidade Estadual Paulista (Unesp)
2015-2023
Centro Universitário de Araraquara
2015-2023
Universidade Federal de Juiz de Fora
2010-2012
Antimicrobial peptides (AMPs) can be found in various organisms, and could considered an alternative for pesticides used to control plant pathogens, including those affecting citrus. Brazil is the largest producer exporter of frozen concentrated orange juice world. However, citrus industry has been affected by several diseases such as canker huanglongbing (HLB), caused bacteria Xanthomonas citri subsp. (X.citri) Candidatus Liberibacter asiaticus (CaLas), respectively. In order these putative...
Skin wound infection requires carefully long-term treatment with an immense financial burden to healthcare systems worldwide. Various strategies such as drug delivery using polymer matrix from natural source have been used enhance healing. Natural rubber latex (NRL) Hevea brasiliensis has shown angiogenic and tissue repair properties. Gentamicin sulfate (GS) is a broad-spectrum antibiotic which inhibits the growth of wide variety microorganisms and, because this, it also applied topically...
Antimicrobial peptides (AMPs) are compounds that act in a wide range of physiological defensive mechanisms developed to counteract bacteria, fungi, parasites and viruses. These molecules have become increasingly important as consequence remarkable microorganism resistance common antibiotics. This report shows Escherichia coli expressing the recombinant antimicrobial peptide Pg-AMP1 previously isolated from Psidium guajava seeds. The deduced open reading frame consists 168 bp long plus...
Paracoccidioidomycosis is a systemic mycosis, endemic in Latin America. The etiologic agents of this mycosis are composed 2 species: Paracoccidioides brasiliensis and P. lutzii. Murine animal models the gold standard for vivo studies; however, ethical, economical logistical considerations limit their use. Galleria mellonella suitable model studies fungal infections. In study, we compared virulence lutzii G. model. deaths larvae infected with or were similar, both species able to reduce...
The interaction between the fungal pathogen Paracoccidioides brasiliensis and host cells is usually mediated by specific binding events adhesins on surface receptors extracellular matrix or cell surface. One molecule implicated in P. brasiliensis-host 14-3-3 protein. protein belongs to a family of conserved regulatory molecules that are expressed all eukaryotic involved diverse cellular functions. Here, we investigated relevance virulence brasiliensis. Using antisense RNA technology...
Invasive fungal infections such as cryptococcosis and paracoccidioidomycosis are associated with significant rates of morbidity mortality. Specially the caused by Cryptococcus neoformans, is distributed worldwide, has received much attention a common complication in patients HIV. usually treated combination amphotericin B azoles. In addition, 5-fluorocytosine (5-FC) applied cryptococcosis, especially to treat central nervous system infection. However, host toxicity, high cost, emerging...
Aim: Geraniol and linalool are major constituents of the essential oils medicinal plants. Materials & methods: Antifungal activity geraniol were evaluated against five Candida species. The genotoxicity these compounds was by cytokinesis-block micronucleus test, embryotoxic assays use zebrafish model. Results: inhibited growth, but more effective. at concentration 800 μg/ml 125 significantly increased chromosome damage. toxic to embryo than linalool: LC50 values 31.3 193.3 μg/ml,...
Aim: Gallic acid and its ester derivatives have shown antifungal activity in vitro. This study was performed to investigate their against Candida albicans toxicity the animal models Caenorhabditis elegans zebrafish embryos. Results: The compounds protected worms from C. infection. dodecyl gallate most effective. In embryo, gallic were least toxic. Conclusion: potential for vivo use effects of esters these alternative dependent on carbon chain length.
Aim: This work aimed to produce a membrane based on fluconazole-loaded natural rubber latex (NRL), and study their interaction, drug release antifungal susceptibility against Candida albicans. Materials & methods: Fluconazole-loaded NRL was obtained by casting method. Results: The Fourier Transform Infrared Spectroscopy showed no modifications either in or fluconazole after the incorporation. Mechanical test presented low Young's modulus high strain, indicating membranes have sufficient...
Aim: This work aimed to evaluate the activity of 3′-hydroxychalcone against Cryptococcus gattii in planktonic and biofilm forms their toxicity using alternative animal models. Materials & methods: Minimum inhibitory concentration minimum fungicide were determined. Biofilm formation susceptibility tests performed by 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-5-[carbonyl(phenylamino)]-2H-tetrazolium hydroxide assay. Toxicity efficacy checked Danio rerio Galleria mellonella Results: The compound...
Aim: This study aimed to evaluate the activity of 2'-hydroxychalcone-loaded in nanoemulsion (NLS + 2'chalc), cytotoxic effect and toxicity against Paracoccidioides brasiliensis lutzii using a zebrafish model. Materials & methods: Preparation physical-chemical characterization (NLS) NLS 2'chalc were performed. MIC minimum fungicide concentration, cytotoxicity also evaluated Danio rerio Results: showed fungicidal spp. without MRC5 HepG2 lines. It had high selectivity index values no model...
causes a fungal respiratory disease. Some studies suggest that the fungus requires zinc to consolidate infection. This study aimed investigate influence of and metal chelator TPEN on growth
MicroRNAs (miRNAs) are small RNAs (length, 19-24 nucleotides) that regulate gene expression by either mRNA degradation or translational inhibition of proteins. Circulating miRNAs, which extremely stable and protected from RNAse‑mediated in body fluids, have appeared as candidate biomarkers for numerous diseases. However, little is known about circulating miRNAs fungal infections. Paracoccidioidomycosis (PCM) caused the Paracoccidioides species, endemic Central South America, with...
The oral cavity is a highly diverse microbial environment in which microorganisms interact with each other, growing as biofilms on biotic and abiotic surfaces. Understanding the interaction among microbiota counterparts pivotal for clarifying pathogenesis of diseases. Candida spp. one most abundant fungi mycobiome ability to cause severe soft tissue lesions under certain conditions. Paracoccidioides spp., causative agent paracoccidioidomycosis, may also colonize leading damage. It was...
Heat shock proteins (Hsps) are among the most widely distributed and evolutionary conserved proteins, acting as essential regulators of diverse constitutive metabolic processes. The Hsp60 dimorphic fungal Histoplasma capsulatum is major surface adhesin to mammalian macrophages studies antibody-mediated protection against H. have provided insight into complexity involving Hsp60. However, nothing known about role regarding biofilms, a mechanism virulence exhibited by . Considering this,...
Dermatophytosis is the most common mycosis worldwide, affecting approximately 20 to 25% of population, regardless gender, race, color and age. Most antifungal agents used for treatment dermatophytosis belong azole allylamine classes. Dermatophytes are reported be resistant commercial drugs, especially microbial biofilms, in addition their considerable toxicity. It should emphasized importance looking new molecules with reduced toxicity, as well targets mechanisms action. This work aims...