A5017904400- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Insect Resistance and Genetics
- Protein Hydrolysis and Bioactive Peptides
- Transgenic Plants and Applications
- Antibiotic Resistance in Bacteria
- Aquaculture disease management and microbiota
- Marine Sponges and Natural Products
- Insect and Pesticide Research
- Entomopathogenic Microorganisms in Pest Control
- Plant-Microbe Interactions and Immunity
- Silk-based biomaterials and applications
- Phytoplasmas and Hemiptera pathogens
- Bacterial biofilms and quorum sensing
- Toxin Mechanisms and Immunotoxins
- Enzyme Production and Characterization
- Venomous Animal Envenomation and Studies
- Nicotinic Acetylcholine Receptors Study
- Nanoparticles: synthesis and applications
- Invertebrate Immune Response Mechanisms
- Phytochemistry Medicinal Plant Applications
- Coral and Marine Ecosystems Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Oral microbiology and periodontitis research
- Plant Parasitism and Resistance
Universidade Católica de Brasília
2016-2025
Universidade de Brasília
2004-2024
Universidade Católica Dom Bosco
2016
Biotech (Brazil)
2016
Centro de Excelência em Bioinformática
2015
Genomic (Brazil)
2012-2015
Brazilian Agricultural Research Corporation
2003-2010
Oceanic environments are one of the largest sources bioactive molecules, due to high degree biodiversity and innumerable ecological relationships established between macro microorganisms found in different ecosystems these complex environments. Marine organisms being studied increasingly because they considered important producers biologically active peptides. Peptides extracted from marine have functions structures, when compared peptides isolated terrestrial sources, considering adaptive...
Cyclotides are a family of plant-derived cyclic peptides comprising six conserved cysteine residues connected by three intermolecular disulfide bonds that form knotted structure known as cystine knot (CCK). This structural motif is responsible for the pronounced stability cyclotides against chemical, thermal, or proteolytic degradation and has sparked growing interest in this peptides. Here, we isolated characterized novel cyclotide from Palicourea rigida (Rubiaceae), which was named...
The study of wasp venoms has captured attention due to the presence a wide variety active compounds, revealing diverse array biological effects. Among these certain antimicrobial peptides (AMPs) such as mastoparans and chemotactic have emerged significant players, characterized by their unique amphipathic short linear alpha-helical structure. These exhibit not only antibiotic properties but also range other activities, which are related ability interact with membranes varying degrees. This...
Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools dentistry. Here, different were tested use during the pulp revascularization process, including poly(vinyl alcohol)-PVA hydrogels or resins, collagen and alcohol) PVA/Chitosan (PVA/CS) nanofibers. Based on time to degradation (21 days), nanofibers chosen be incorporated ciprofloxacin IDR-1002 (each at 50 mg/g). Nanofibers containing had anti-biofilm activity...
Corals can be considered holobiont organisms, since they have an important symbiotic relationship with microbial communities such as zooxanthellae, bacteria, Archaea, fungi and viruses. It is to understand how those influence the health of corals environmental conditions could affect them. The present study aimed describe bacterial associated three Brazilian coral species, Millepora alcicornis, Mussismilia harttii Phyllogorgia dilatata, by a culture-independent method, using 16S rRNA gene...
Antimicrobial peptides have been found in mollusks and other sea animals. In this report, a crude extract of the marine snail Cenchritis muricatus was evaluated against human pathogens responsible for multiple deleterious effects diseases. A peptide 1485.26 Da purified by reversed-phase HPLC functionally characterized. This trypsinized sequenced MS/MS technology, sequence (SRSELIVHQR), named Cm-p1 recovered, chemically synthesized demonstrated capacity to prevent development yeasts...
Antimicrobial peptides (AMPs) are compounds that act in a wide range of physiological defensive mechanisms developed to counteract bacteria, fungi, parasites and viruses. These molecules have become increasingly important as consequence remarkable microorganism resistance common antibiotics. This report shows Escherichia coli expressing the recombinant antimicrobial peptide Pg-AMP1 previously isolated from Psidium guajava seeds. The deduced open reading frame consists 168 bp long plus...
Abstract The antimicrobial peptides (AMPs) are evolutionarily ancient molecules that act as components of the innate immune system. Recently, it was demonstrated a single AMP can perform various functions; this ability is known “peptide promiscuity.” However, little about promiscuity in plant AMPs without disulfide bonds. This study carried out to evaluate Cn ‐AMP1: promising disulfide‐free peptide with reduced size and cationic hydrophobic properties. Its activity against human pathogenic...
Healthcare-associated infections (HAIs) are causes of mortality and morbidity worldwide. The prevalence bacterial resistance to common antibiotics has increased in recent years, highlighting the need develop novel alternatives for controlling these pathogens. Pitviper venoms composed a multifaceted mixture peptides, proteins inorganic components. L-amino oxidase (LAO) is multifunctional enzyme that able different activities including antibacterial activity. In this study LAO from Bothrops...
Antimicrobial peptides (AMPs) are effective antibiotic agents commonly found in plants, animals, and microorganisms, they have been suggested as the future of antimicrobial chemotherapies. It is vital to understand molecular details that define mechanism action resistance AMPs for a rational planning next generation also shed some light on complex AMP action. Here, Escherichia coli ATCC 8739 magainin I was evaluated cytosolic subproteome. Magainin-resistant strains were selected after 10...
Antimicrobial peptides form part of the first line defense against pathogens for many organisms. Current treatments fungal infections are limited by drug toxicity and pathogen resistance. Cm-p5 (SRSELIVHQRLF), a peptide derived from marine mollusk Cenchritis muricatus Cm-p1, has significantly increased fungistatic activity pathogenic Candida albicans (minimal inhibitory concentration, 10 µg/ml; EC50, 1.146 µg/ml) while exhibiting low toxic effects cultured mammalian cell line. as...