A5016784901- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Probiotics and Fermented Foods
- Bacteriophages and microbial interactions
- Healthcare and Venom Research
- Antibiotic Resistance in Bacteria
- Venomous Animal Envenomation and Studies
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Food Allergy and Anaphylaxis Research
- Monoclonal and Polyclonal Antibodies Research
- Viral Infectious Diseases and Gene Expression in Insects
- Cholinesterase and Neurodegenerative Diseases
- Transgenic Plants and Applications
- Insect and Pesticide Research
- Vibrio bacteria research studies
- Chemical Synthesis and Analysis
- Bacterial biofilms and quorum sensing
- Bee Products Chemical Analysis
- Invertebrate Immune Response Mechanisms
Universidade Católica de Brasília
2019-2024
Universidade de Brasília
2012-2017
The study of wasp venoms has captured attention due to the presence a wide variety active compounds, revealing diverse array biological effects. Among these certain antimicrobial peptides (AMPs) such as mastoparans and chemotactic have emerged significant players, characterized by their unique amphipathic short linear alpha-helical structure. These exhibit not only antibiotic properties but also range other activities, which are related ability interact with membranes varying degrees. This...
Antimicrobial peptides (AMP) have received particular attention due to their capacity kill bacteria. Although much is known about them, are currently being further researched. A large number of AMPs been discovered, but only a few approved for topical use, promiscuity and other challenges, which need be overcome.AMPs diverse in structure. Consequently, they varied action mechanisms when targeting microorganisms or eukaryotic cells. Herein, the authors focus on linear peptides, particularly...
In the present study we conducted proteomic and pharmacological characterizations of venom extracted from Brazilian tarantula Acanthoscurria paulensis, evaluated cardiotoxicity its two main fractions. The molecular masses components were identified by mass spectrometry (MALDI-TOF-MS) after chromatographic separation (HPLC). lethal dose (LD(50)) was determined in mice. Nociceptive behavior intradermal injection mice edematogenic activity rat hind-paw assay. Cardiotoxic on situ frog heart...
Abstract Background The synthetic antimicrobial peptide, PaDBS1R1, has been reported as a powerful anti-Klebsiella pneumoniae antimicrobial. However, there is only scarce knowledge about whether K. could develop resistance against PaDBS1R1 and which mechanisms be involved. Objectives Identify via label-free shotgun proteomics the developed PaDBS1R1. Methods An adaptive laboratory evolution experiment was performed to obtain PaDBS1R1-resistant lineage. Antimicrobial susceptibility determined...