A5045365360- Healthcare and Venom Research
- Insect and Pesticide Research
- Antimicrobial Peptides and Activities
- Neurobiology and Insect Physiology Research
- Venomous Animal Envenomation and Studies
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Cholinesterase and Neurodegenerative Diseases
- Biochemical and Structural Characterization
- Nicotinic Acetylcholine Receptors Study
- Protein Hydrolysis and Bioactive Peptides
- Insect Utilization and Effects
- Toxin Mechanisms and Immunotoxins
- Epilepsy research and treatment
- Psychedelics and Drug Studies
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Lipid Membrane Structure and Behavior
- Pharmacological Effects and Toxicity Studies
- Neurotransmitter Receptor Influence on Behavior
- Computational Drug Discovery Methods
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Autism Spectrum Disorder Research
Universidade de Brasília
2016-2025
Hospital Universitário da Universidade de São Paulo
2024
Universidade de São Paulo
2005-2024
Sarah Network of Rehabilitation Hospitals
2024
Universidade de Ribeirão Preto
2004
Abstract Parkinson's disease (PD) is a progressive and chronic neurodegenerative of the central nervous system. Early treatment for PD efficient; however, long-term systemic medication commonly leads to deleterious side-effects. Strategies that enable more selective drug delivery brain using smaller dosages, while crossing complex brain-blood barrier (BBB), are highly desirable ensure efficacy decrease/avoid unwanted outcomes. Our goal was design test neurotherapeutic potential forefront...
The incidence of fungal infections has been increasing in the last decades, while number available antifungal classes remains same. natural and acquired resistance some species to therapies, associated with high toxicity these drugs on present scenario makes an imperative search for new, more efficient less toxic therapeutic choices. Antimicrobial peptides (AMPs) are a potential class antimicrobial consisting evolutionarily conserved multifunctional molecules both microbicidal...
ABSTRACT Many neurodegenerative diseases are directly related to the formation of toxic protein aggregates, such as Alzheimer's disease, which is associated with aggregation amyloid‐beta (A β ). In this context, fibrils hallmark these diseases. sense, developing compounds capable preventing or reducing in brain can be fundamental importance for curative treatment Animals' venom known selected nervous system targets, therefore, they considered an interesting platform pharmacological tools....
Stingrays commonly cause human envenoming related accidents in populations of the sea, near rivers and lakes. Transcriptomic profiles have been used to elucidate components animal venom, since they are capable providing molecular information on biology could biomedical applications. In this study, we elucidated transcriptomic profile venom glands from two different freshwater stingray species that endemic Paraná-Paraguay basin Brazil, Potamotrygon amandae falkneri. Using RNA-Seq, identified...
Intravascular stent infection is a rare complication with high morbidity and mortality; bacteria from the hospital environment form biofilms are often multidrug-resistant (MDR). Antimicrobial peptides (AMPs) have been considered as alternatives to bacterial treatment. We analyzed formation of biofilm on vascular stents also tested inhibition this by AMPs be used treatment or coating. activity antibiofilm were wasp (Agelaia-MPI, Polybia-MPII, Polydim-I) scorpion (Con10 NDBP5.8) against...
The impact of neurological disorders in society is growing with alarming estimations for an incidence increase the next decades. These are generally chronic and can affect individuals early during productive life, imposing real limitations on performance their social roles. Patients have independence, autonomy, freedom, self-image, self-confidence affected. In spite availability, drugs treatment these commonly associated side effects, which vary frequency severity. Currently, no effective...
In this work, a neuroactive peptide from the venom of neotropical wasp Polybia occidentalis was isolated and its anti-nociceptive effects were characterized in well-established pain induction models.Wasp analysed by reverse-phase HPLC fractions screened for activity. The structure most active fraction identified electron-spray mass spectrometry (ESI-MS/MS) it further assessed two tests activity rats: hot plate tail flick tests.The contained whose Arg-Pro-Pro-Gly-Phe-Thr-Pro-Phe-Arg-OH, which...
Cell damage and spatial localization deficits are often reported as long-term consequences of pilocarpine-induced status epilepticus. In this study, we investigated the neuroprotective effects repeated drug administration after long-lasting Groups six to eight Wistar rats received microinjections pilocarpine (2.4 mg/microl, 1 microl) in right dorsal hippocampus induce a epilepticus, which was attenuated by thiopental injection (35 mg/kg, i.p.) 3 hrs onset. Treatments consisted i.p. diazepam,...
The scorpion Tityus serrulatus is responsible for the most severe accidents that have been registered in Brazil, mainly state of Minas Gerais (MG), being lung edema (LE), main cause death these accidents. Although an increased number caused to this species Federal District (Distrito – DF), it seems particular not scorpionism cases region. Given observation, we tested toxicity mice and compared ability T. venom from DF (Ts-DF) State (Ts-MG) induce LE rats. LD50 Ts-DF was 51.6 μg/mouse, almost...
Mycobacterium abscessus subsp. massiliense, a rapidly growing mycobacteria (RGM) that is becoming increasingly important among human infectious diseases, virulent and pathogenic presents intrinsic resistance to several antimicrobial drugs might hamper their elimination. Therefore, the identification of new improve current treatment or lower risk inducing urgently needed. Wasp venom primarily comprises peptides are responsible for most biological activities in this poison. Here, novel peptide...
Mycobacterium massiliense is a rapid growing, multidrug-resistant, non-tuberculous mycobacteria that responsible for wide spectrum of skin and soft tissue infections, as well other organs, such the lungs. Antimicrobial peptides had been described broad-spectrum antimicrobial, chemotactic, immunomodulator molecules. In this study we evaluated an antimicrobial peptide derived from scorpion Tityus obscurus anti-mycobacterial agent in vitro vivo. Bioinformatics analyses demonstrated ToAP2 have...
To improve the oral absorption of fish oil and test its anti-inflammatory effect, a nanoemulsion was developed using cis-4,7,10,13,16,19-docosahexaenoic fatty acid as biomarker for administration. The colloidal stability tests showed an average size 155.44 nm ± 6.46 (4 °C); 163.04 9.97 (25 °C) polydispersity index 0.22 0.02 °C), 0.21 indicating systems with low stable droplets. did not alter cell viability RAW 264.7 macrophages and, at concentration 0.024 mg/mL, kinetically incorporated into...
Animal venoms are rich sources of neuroactive compounds, including anti-inflammatory, antiepileptic, and antinociceptive molecules. Our study identified a protonectin peptide from the wasp Parachartergus fraternus' venom using mass spectrometry cDNA library construction. Using this as template, we designed new peptide, protonectin-F, which exhibited higher activity less motor impairment compared to protonectin. In drug interaction experiments with naloxone AM251, Protonectin-F's was...