A5043447738- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Advanced Drug Delivery Systems
- Antimicrobial Peptides and Activities
- Nail Diseases and Treatments
- Bee Products Chemical Analysis
- Nanocomposite Films for Food Packaging
- Wound Healing and Treatments
- Studies on Chitinases and Chitosanases
- Advancements in Transdermal Drug Delivery
- Enzyme Production and Characterization
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Essential Oils and Antimicrobial Activity
- Microbial Metabolites in Food Biotechnology
- Antimicrobial agents and applications
- Reproductive tract infections research
- Plant Pathogens and Fungal Diseases
- Enzyme Catalysis and Immobilization
- Circadian rhythm and melatonin
- Advanced biosensing and bioanalysis techniques
- Biochemical and Structural Characterization
- Pressure Ulcer Prevention and Management
- Microbial Metabolic Engineering and Bioproduction
- Medical and Biological Ozone Research
Universidade Federal de Goiás
2016-2025
Universidade de Brasília
2005-2024
Radboud University Nijmegen
2024
Instituto de Saúde
2021
Universidade Católica de Brasília
2008-2010
Abstract Parkinson's disease (PD) is a progressive and chronic neurodegenerative of the central nervous system. Early treatment for PD efficient; however, long-term systemic medication commonly leads to deleterious side-effects. Strategies that enable more selective drug delivery brain using smaller dosages, while crossing complex brain-blood barrier (BBB), are highly desirable ensure efficacy decrease/avoid unwanted outcomes. Our goal was design test neurotherapeutic potential forefront...
Vulvovaginal candidiasis (VVC) is caused mainly by the opportunistic fungus Candida albicans, and its yeast to hyphae transition considered a major virulence factor. Farnesol molecule that inhibits transition. The increased incidence of VVC has influenced need for developing new therapeutic strategies. objective was develop mucoadhesive nanostructured system composed miconazole farnesol co-encapsulated within chitosan nanoparticles. presented minimal inhibitory concentration (MIC) 1 μg/ml...
ObjectivesThe present study reports on the preparation and testing of a desoxycholate amphotericin B (D-AMB) sustained delivery system based poly(lactic-co-glycolic acid) (PLGA) dimercaptosuccinic acid (DMSA) polymeric blends (Nano-D-AMB) aimed at reducing number AMB administrations required to treat mycosis.
Abstract The bovine papillomavirus (BPV) is known to cause lesions in the epithelial tissue of cattle, which causes papillomatoses. This disease characterized by wart different body parts, causing losses animal value. Despite economic impact, there are no effective vaccines available at this moment. present study aims develop a nanoformulated autogenous vaccine using inactivated virus warts control diseases associated with BPV. To end, was collected from infected bovines on farm Goiás,...
Background and purpose: The present study reports on the preparation testing of a sustained delivery system for immunomodulatory peptide P10 aimed at reducing in vivo degradation amount required to elicit protective immune response against paracoccidioidomycosis. Experimental approach: BALB/c mice were infected with yeast Paracoccidioides brasiliensis mimic chronic form animals treated daily sulfamethoxazole/trimethoprim alone or combined P10, either emulsified Freund's adjuvant entrapped...
The conventional treatment for paracoccidioidomycosis, the most prevalent mycosis in Latin America, involves long periods of therapy resulting sequels and high frequency relapses. search new alternatives is necessary. Previously, we have demonstrated that hsp65 gene from Mycobacterium leprae shows prophylactic effects against murine paracoccidioidomycosis. Here, tested DNAhsp65 immunotherapy BALB/c mice infected with Paracoccidioides brasiliensis, agent We observed an increase Th1 cytokines...
A remarkable and intriguing challenge for the modern medicine consists in development of alternative therapies to avoid problem microbial resistance. The cationic antimicrobial peptides present a promise be used develop more efficient drugs applied human health. silico analysis genomic databases is strategy utilized predict therapeutic interest. Once main peptides' physical–chemical properties are already known, correlation those features search on these tool shorten identifying new...
Vaccines play an essential role in keeping humans healthy. Innovative approaches to their use include the utilization of plasmid DNA encoding sequences express foreign antigens. DNAhsp65 from Mycobacterium leprae is suitable for this purpose due its ability elicit a powerful immune response. Controlled release systems represent promising approach delivering vaccines. In work, we used liposomes or PLGA deliver treat pulmonary fungal infection Paracoccidioidomycosis. Both formulations...
Itraconazole (ITZ) has a broad spectrum of action and is commonly used for the treatment fungal infections. Topic administration ITZ promising strategy to improve vulvovaginal candidiasis treatment, which can be further optimized by its encapsulation in nanoparticles increase drug delivery reduce toxicity. In this work, we designed polycaprolactone containing evaluated vivo efficacy yet unexplored approach. Nanocapsules (ITZ-NC) nanospheres (ITZ-NS) were obtained nanoprecipitation. ITZ-NC...
Paracoccidioidomycosis (PCM) is a systemic mycosis, widespread in Latin America. PCM granulomatous disease characterized by polymorphism of lesions depending on the pathogen's virulence, immune status host and its genetic susceptibility. The thermodimorphic fungus Paracoccidioides brasiliensis was considered only etiologic agent PCM, yet recent works have shown significant diversity among different strains P. brasiliensis. Therefore, it has been proposed for new species within genus, named...
Paracoccidioidomycosis (PCM) is a granulomatous fungal disease caused by the dimorphic species of Paracoccidioides, which mainly affects lungs. Modern strategies for treatment and/or prevention PCM are based on Th1-type immune response, important controlling disease. One most studied candidates vaccine P10 peptide, derived from 43 kDa glycoprotein Paracoccidioides brasiliensis. In order to improve its modulatory effect, peptide was associated with chitosan-conjugated nanoparticle. The...