A5081743565- Nanoparticle-Based Drug Delivery
- Characterization and Applications of Magnetic Nanoparticles
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Protein Interaction Studies and Fluorescence Analysis
- Iron oxide chemistry and applications
- Geomagnetism and Paleomagnetism Studies
- Electromagnetic Fields and Biological Effects
- Erythrocyte Function and Pathophysiology
- Magnetic and Electromagnetic Effects
- Hemoglobin structure and function
- Microfluidic and Bio-sensing Technologies
- Trypanosoma species research and implications
- Blood properties and coagulation
- Ultrasound and Hyperthermia Applications
- Force Microscopy Techniques and Applications
- Iron Metabolism and Disorders
- Nanoparticles: synthesis and applications
- Microtubule and mitosis dynamics
- Lipid Membrane Structure and Behavior
- Antioxidant Activity and Oxidative Stress
- 3D Printing in Biomedical Research
- Clinical Nutrition and Gastroenterology
- Genetically Modified Organisms Research
- Bee Products Chemical Analysis
Universidade de Brasília
2009-2022
Instituto de Ciencias Tecnológicas
2012
Inserm
2002
Northwestern University
1995
ObjectivesThe present study reports on the preparation and testing of a desoxycholate amphotericin B (D-AMB) sustained delivery system based poly(lactic-co-glycolic acid) (PLGA) dimercaptosuccinic acid (DMSA) polymeric blends (Nano-D-AMB) aimed at reducing number AMB administrations required to treat mycosis.
Human and animal immune functions present sex dimorphism that seems to be mainly regulated by hormones. In the study, activities of antioxidant enzymes total superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) were measured in intraperitoneal resident macrophages from adult male female rats. addition comparing males females, we also examined regulation these enzyme steroids. GSH-Px activity did not differ between macrophages. However, both SOD CAT markedly higher...
In the last decade, many different kinds of therapies have emerged as a consequence advances in field applied technology. It is known that low level laser therapy contributes to tissue healing; however, use photodynamic (PDT) healing and scar formation processes has not been fully explored. The present study analyses effect InGaAIP (685 nm), radiation, either alone or combined with phthalocyanine-derived photosensitizer (PS) gel base delivery (GB) system, on process cutaneous wounds rats.The...
Breast tumors represent the most common malignant tumors. Current treatments for humans and pets rely on tumor excision adjuvant chemotherapy, which may affect both cancer cells normal cells. Photodynamic therapy (PDT) is an approved treatment modality a variety of cancers was recently recommended as first-line non-melanoma skin humans. The main purpose present study to determine efficacy PDT using aluminum-chloride-phthalocyanine that encapsulated in liposomes LED light source kill...
Preliminary biocompatibility investigation of magnetic albumin nanosphere designed as a potential versatile drug delivery system Luciana Estevanato1, Débora Cintra1, Nayara Baldini1, Flávia Portilho1, Luzirlane Barbosa1, Olímpia Martins2, Bruno Lacava3, Ana Luisa Miranda-Vilela1, Antônio Cláudio Tedesco2, Sônia Báo1, Paulo C Morais4, Zulmira GM Lacava11Instituto de Ciências Biológicas, Universidade Brasília, 2Departamento...
Abstract: Nanosized maghemite particles were synthesized, precoated (with dimercaptosuccinic acid) and surface-functionalized with anticarcinoembryonic antigen (anti-CEA) successfully used to target cell lines expressing the CEA, characteristic of colorectal cancer (CRC) cells. The as-developed nanosized material device, consisting surface decorated nanoparticles suspended as a biocompatible magnetic fluid (MF) sample, labeled MF-anti-CEA, was characterized tested against two lines: high-CEA...
Magnetic resonance is used to investigate biodistribution aspects of dextran-coated magnetite nanoparticles (9.4 nm core diameter) in both liver and spleen from 5 minutes up 6 months after intravenous administration a magnetic fluid sample female Swiss mice. Using data important parameters such as the absorption half-life (t 1/2 = 12 +/- 2 min t 11 spleen), peak time (1.7 0.2 h 1.9 disposition mice organs 70 10 32 7 spleen) were assessed. In addition, light electron microscopy showed several...
Atomic force microscopy (AFM), transmission electron (TEM), and static magnetic birefringence (SMB) were used to unfold the particle size polydispersity profile of a magnetite-based fluid sample. The data obtained from different techniques curve fitted using lognormal distribution function, which mean diameter (Dm) standard deviation (σ) obtained. In comparison TEM data, AFM show reduction Dm (about 20%) an increase σ 15%). contrast, close agreement between SMB was found.
In this study a magnetic nanoemulsion (MNE) was developed from mixture of two components, namely biodegradable surfactants and biocompatible citrate-coated cobalt ferrite-based fluid, for entrapment Zn(II)-Phthalocyanine (ZnPc), the latter classical photosensitizer (PS) species used in photodynamic therapy (PDT) procedures. The sample's stability evaluated as function time using photocorrelation spectroscopy (PCS) determination average hydrodynamic diameter, diameter dispersion zeta...
Metformin (dimethyl-biguanide) is an insulin-sensitizing agent that lowers fasting plasma-insulin concentration, wherefore it's wide use for patients with a variety of insulin-resistant and prediabetic states, including impaired glucose tolerance. During pregnancy it further resource reducing first-trimester loss in women the polycystic ovary syndrome. We tested metformin genotoxicity cells Chinese hamster ovary, CHO-K1 (chromosome aberrations; comet assays) mice (micronucleus assays)....