A5054100388- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Porphyrin and Phthalocyanine Chemistry
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Laser Applications in Dentistry and Medicine
- Parasites and Host Interactions
- Phytochemistry Medicinal Plant Applications
- Oral health in cancer treatment
- Oral microbiology and periodontitis research
- Head and Neck Cancer Studies
- Cancer Research and Treatments
- bioluminescence and chemiluminescence research
- Parasite Biology and Host Interactions
- Nanoparticles: synthesis and applications
- Proteins in Food Systems
- Complementary and Alternative Medicine Studies
- Antimicrobial Peptides and Activities
- Gold and Silver Nanoparticles Synthesis and Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Helminth infection and control
- Cancer Immunotherapy and Biomarkers
- Healthcare Regulation
- Biochemical and Structural Characterization
Universidade de Brasília
2016-2025
Institut des Sciences Biologiques
2017-2025
Morpho (United States)
2025
GTx (United States)
2017-2018
Universidade Federal do Rio Grande do Norte
2017
Universidade Federal do Amazonas
2017
Abstract Background Metastasis causes the most breast cancer-related deaths in women. Here, we investigated antitumor effect of solid lipid nanoparticles (SLN-DTX) when used treatment metastatic tumors using 4T1-bearing BALB/c mice. Results Solid (SLNs) were produced high-energy method. Compritol 888 ATO was selected as matrix, and Pluronic F127 Span 80 surfactants to stabilize nanoparticle dispersion. The particles had high stability for at least 120 days. SLNs’ dispersion size 128 nm,...
Photodynamic therapy (PDT) combines light, molecular oxygen and a photosensitizer to induce oxidative stress in target cells. Certain hydrophobic photosensitizers, such as aluminium-phthalocyanine chloride (AlPc), have significant potential for antitumor PDT applications. However, molecules often require drug-delivery systems, nanostructures, improve their pharmacokinetic properties prevent aggregation, which has quenching effect on the photoemission aqueous media. As result, this work aims...
Abstract: Photodynamic therapy is generally considered to be safer than conventional anticancer therapies, and it effective against different kinds of cancer. However, its clinical application has been significantly limited by the hydrophobicity photosensitizers. In this work, a system composed hydrophobic photosensitizer aluminum–phthalocyanine chloride (AlPc) associated with water dispersible poly(methyl vinyl ether-co-maleic anhydride) nanoparticles described. AlPc was produced method...
The use of microwave-assisted synthesis (in water) α-Fe2O3 nanomaterials followed by their transformation onto iron oxide Fe3O4-γ-Fe2O3 hollow nanoparticles encoding well-defined sizes and shapes [nanorings (NRs) nanotubes (NTs)] is henceforth described. impact experimental variables such as concentration reactants, volume solvent employed, reaction times/temperatures during the shape-controlled revealed that key factor gated generation morphologically diverse was associated to initial...
Photodynamic therapy (PDT) has been clinically employed to treat mainly superficial cancer, such as basal cell carcinoma. This approach can eliminate tumors by direct cytotoxicity, tumor ischemia, or triggering an immune response against cells. Among the immune-related mechanisms of PDT, induction immunogenic death (ICD) in target cells is be cited. ICD apoptosis modality distinguished emission damage-associated molecular patterns (DAMP). Therefore, this study aimed analyze immunogenicity...
A new Keap1-Nrf2 protein-protein interaction (PPI) inhibitor ZJ01 was identified from our compound library by fluorescence polarization assay, surface plasmon resonance, molecular docking and dynamics simulation. could in vitro trigger Nrf2 nuclear translocation, subsequently resulting increased mRNA levels of target genes HO-1 NQO1. Meanwhile, suppressed LPS-induced production ROS the pro-inflammatory cytokines TNF-α, IL-1β IL-6 H9c2 cardiac cells. Moreover, an vivo mouse model septic...
The increasing incidence of cancer and the search for more effective therapies with minimal collateral effects have prompted studies to find alternative new treatments. Among these, photodynamic therapy (PDT) has been proposed as a very promising modality in treatment lowest rates side effects, revealing itself be particularly successful when photosensitizer is associated nanoscaled carriers. This study aimed design develop formulation based on albumin nanospheres containing...
Eight new peptides were isolated from the skin secretion of frog Leptodactylus pustulatus and their amino acid sequences determined by de novo sequencing cDNA cloning. Structural similarities between them other antimicrobial genus frogs found. Ocellatins-PT1 to -PT5 (25 residues) are amidated at C-terminus, while ocellatins-PT6 -PT8 (32 have free carboxylates. Antimicrobial activity, hemolytic tests, cytotoxicity against a murine fibroblast cell line investigated. All peptides, except for...
Diets rich in omega-3 or -6 fatty acids will produce different profiles for cell membranes phospholipid constitutions. Omegas 3 and 6 are part of the diet can modulate inflammatory profile. We evaluated effects oral absorption fish oil, when associated with a lipid nanoemulsion an experimental pulmonary model. Pulmonary fibrosis is disease excessive extracellular matrix deposition. determined to investigate morphophysiological mechanisms mice that were pretreated after induction bleomycin...
Photodynamic therapy (PDT) mediated by photosensitizers loaded in nanostructures as solid lipid nanoparticles has been pinpointed an effective and safe treatment against different skin cancers. Amazon butters have interesting composition when it comes to forming (SLN). In the present report, a new third-generation photosensitizing system consisting of aluminum-phthalocyanine associated with butter-based (SLN-AlPc) is described. The SLN was developed using murumuru butter, monodisperse...