A5026937228- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antimicrobial Peptides and Activities
- Inhalation and Respiratory Drug Delivery
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Extracellular vesicles in disease
- Food composition and properties
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Toxoplasma gondii Research Studies
- Immune Response and Inflammation
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Microbial Metabolites in Food Biotechnology
- Protein Hydrolysis and Bioactive Peptides
- Fungal Infections and Studies
- Natural Antidiabetic Agents Studies
Universidade de Brasília
2019-2024
Diets rich in omega-3 or -6 fatty acids will produce different profiles for cell membranes phospholipid constitutions. Omegas 3 and 6 are part of the diet can modulate inflammatory profile. We evaluated effects oral absorption fish oil, when associated with a lipid nanoemulsion an experimental pulmonary model. Pulmonary fibrosis is disease excessive extracellular matrix deposition. determined to investigate morphophysiological mechanisms mice that were pretreated after induction bleomycin...
Antimicrobial peptides (AMPs) are small molecules with microbicidal and immunoregulatory activities. In this study we evaluated the anti-inflammatory antimicrobial activities of ToAP3 ToAP4, AMPs from venom Brazilian scorpion Tityus obscurus. To test peptides' activity, murine bone marrow-derived macrophages (BMDMs) or dendritic cells (BMDCs) were stimulated plus LPS to analyze their ability modulate cytokine release as well phenotypic markers. For analysis, indirect activity against...
Chromoblastomycosis (CBM) is a chronic cutaneous and subcutaneous mycosis caused by black, dimorphic, filamentous fungi of the Herpothrichiellaceae family, such as species genus Fonsecaea . These can switch between saprophytic forms (conidia hyphae) pathogenic form, muriform cells (MCs), which considered an essential mechanism for fungal virulence. Nearly all types produce membranous structures formed lipid bilayer that communicate extracellularly with other cells, known “extracellular...
Idiopathic pulmonary fibrosis (IPF) is a progressive, relentless, and deadly disease. Little known about its pathogenetic mechanisms; therefore, developing efficient pharmacological therapies challenging. This work aimed to apply therapeutic alternative using immunomodulatory peptides in chronic murine model. BALB/c mice were intratracheally instilled with bleomycin (BLM) followed for 30 days. The treated the immune modulatory ToAP3 ToAP4 every three days, starting on 5th day post-BLM...
The consumption of nutraceuticals or food supplements has increased crucially, aiming to address nutrient deficits and enhance immune system function. To develop safe products with unique nutritional functional benefits, new production methods these such as the fermentative process have been gaining prominence for industrial applications. Bionutri-AR1
This work explores the use of immunomodulatory peptide ToAP3 from <i>T. obscurus</i> in a murine model idiopathic pulmonary fibrosis (IPF) aiming to evaluate this its potential as new pharmacological therapy. IPF is rare, deadly, specific form chronic progressive fibrosing interstitial pneumonia unknown cause occurring adults, limited lungs. Treatments for nosological entity are and only able delay disease's progression. They were developed interfere directely with fibrotic process no pupose...
Antimicrobial peptides are small molecules that engage in the innate immune response of all vertebrate and invertebrate species, endowed with antimicrobial, antiparasitic, antiviral anti-inflammatory activity. This project aims to analyze some those properties four wasp-derived vitro assays evaluate its mechanisms bleomycin treated BALB\c mice idiopathic pulmonary fibrosis model. In assays, we evaluated cellular toxicity immunomodulatory activity LPS-stimulated murine peritoneal macrophages....