A5056476391- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Cardiac Valve Diseases and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ion-surface interactions and analysis
- Cardiovascular Function and Risk Factors
- Eosinophilic Disorders and Syndromes
- Nitric Oxide and Endothelin Effects
- Infective Endocarditis Diagnosis and Management
- Cancer Research and Treatments
- Graphene and Nanomaterials Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Photodynamic Therapy Research Studies
- Receptor Mechanisms and Signaling
- Nanopore and Nanochannel Transport Studies
- Heart Failure Treatment and Management
- Advanced MRI Techniques and Applications
- Ultrasonics and Acoustic Wave Propagation
- Cardiovascular Effects of Exercise
- Glass properties and applications
- Nanoparticles: synthesis and applications
- TiO2 Photocatalysis and Solar Cells
- Cardiovascular and exercise physiology
- Analytical chemistry methods development
- Nanomaterials for catalytic reactions
Leipzig Heart Institute
2021-2024
Leipzig University
2017-2024
Universidade de Brasília
2017
Czech Academy of Sciences, Institute of Biophysics
2017
RWTÜV (Germany)
1987
Exploring cellular uptake of iron oxide nanoparticles associated with rhodium citrate in breast cancer cells Natalia L Chaves,1 Irina Estrela-Lopis,2 Julia Böttner,2 Cláudio AP Lopes,1 Bruna C Guido,1 Aparecido R de Sousa,3 Sônia N Báo1 1Institute Biological Sciences, Department Cell Biology, University Brasília (UnB), Brasília, Brazil; 2Institute Biophysics and Medical Physics, Leipzig, Germany; 3Institute Chemistry, Federal Goiás,...
Clonal hematopoiesis (CH)-associated mutations increase the risk of atherosclerotic cardiovascular diseases. However, it is unclear whether detected in circulating blood cells can also be tissues associated with atherosclerosis, where they could affect physiology locally. To address this, presence CH peripheral blood, lesions and was assessed a pilot study 31 consecutive patients vascular disease (PAD) who underwent open surgical procedures. Next-generation sequencing used to screen most...
Abstract Diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF) is characterised by increased left ventricular stiffness and impaired active relaxation. Underpinning pathomechanisms are incompletely understood. Cardiac hypertrophy end stage disease associated alterations the cardiac microtubule (MT) network. Increased amounts modifications of α-tubulin associate myocardial stiffness. MT HFpEF have not been analysed yet. Using ZSF1 obese rats (O-ZSF1), a validated...
The increasing use of nanoparticles (NP) in commercial products requires elaborated techniques to detect NP the tissue exposed organisms. However, due low amount material, detection and exact localization within sections is demanding. In this respect, Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) Beam Microscopy (IBM) are promising techniques, because they both offer sub-micron lateral resolutions along with high sensitivities. Here, we compare performance...
Abstract Background Nanocarriers have the potential to improve therapeutic index of currently available drugs by increasing drug efficacy, lowering toxicity and achieving steady-state levels over an extended period. The association maghemite nanoparticles (NPs) with rhodium citrate (forming complex hereafter referred as MRC) has increase specificity cytotoxic action latter compound, since this nanocomposite can be guided or transported a target use external magnetic field. However, behavior...
The aim of this work was to develop and test the<italic>in vitro</italic>biological activity nanocapsules loaded with a doxorubicin (DOX) free base dissolved in core castor oil shelled by poly(methyl vinyl ether-<italic>co</italic>-maleic anhydride) conjugated to<italic>n</italic>-octadecylamine residues.
A restoration of low homoarginine (hArg) levels in obese ZSF1 rats (O-ZSF1) before (S1-ZSF1) and after (S2-ZSF1) the manifestation heart failure with preserved ejection fraction (HFpEF) did not affect worsening cardiac HFpEF characteristics. Here, potential regulation key enzymes arginine metabolism other organs was analyzed. Arginase 2 (ARG2) reduced >35% kidney small intestine hArg-supplemented compared to O-ZSF1. Glycine amidinotransferase (GATM) 29% upregulated kidneys S1-ZSF1....
Abstract Background Heart failure (HF) is the leading cause of death in western countries. Cardiac dysfunction accompanied by skeletal alterations resulting muscle weakness and fatigue. Exercise an accepted interventional approach correcting cardiac dysfunction, thereby improving mortality, re-hospitalization quality life. Animal models are used to characterize underpinning mechanisms. Transverse aortic constriction (TAC) results pressure overload finally HF. Whether exercise training...
Abstract Abuse of amphetamine-type stimulants is linked to cardiovascular adverse effects like arrhythmias, accelerated atherosclerosis, acute coronary syndromes and sudden cardiac death. Excessive catecholamine release following amphetamine use causes vasoconstriction vasospasms, over time leading hypertension, endothelial dysfunction or even cardiotoxicity. However, immediate vascular pathomechanisms related exposure, especially function, remain incompletely understood were analyzed in...
Introduction Fibro-calcific aortic valve disease has high prevalence and is associated with significant mortality. Fibrotic extracellular matrix (ECM) remodeling calcific mineral deposition change the valvular microarchitecture deteriorate function. Valvular interstitial cells (VICs) in profibrotic or procalcifying environment are frequently used vitro models. However, processes take several days to weeks develop, even vitro. Continuous monitoring by real-time impedance spectroscopy (EIS)...
Micrometer width and nanometer thick wires with different shapes were produced $\approx 3~\upmu$m below the surface of a diamond crystal using microbeam He$^+$ ions 1.8~MeV energy. Initial samples are amorphous after annealing at $T\approx 1475$~K, crystallized into graphite-like structures, according to confocal Raman spectroscopy measurements. The electrical resistivity room temperature is only one order magnitude larger than in-plane highly oriented pyrolytic bulk graphite shows small...
Abstract Für die Ermittlung bruchmechanischer Kennwerte stehen mehrere ausgereifte Verfahren zur Verfügung. Bei zäheren Werkstoffen wird das J‐Integral‐Verfahren angewandt. Zur Untersuchung sehr zäher Werkstoffe gibt es Zeit kein genormtes Verfahren. Die kontinuierliche Messung der Rißtiefe bei zähen ist schwierig. In vorliegenden Arbeit am Beispiel zweier austenitischer Stähle eine Möglichkeit indirekten kontinuierlichen Bestimmung mittels Gleichstrompotentialsonde unter Einführung einer...
Abstract Fibro-calcific aortic valve disease (FCAVD) is a pathological condition marked by overt fibrous and calcific extracellular matrix (ECM) accumulation that leads to valvular dysfunction left ventricular outflow obstruction. Costly implantation the only approved therapy. Multiple pharmacological interventions are under clinical investigation, however, none has proven clinically beneficial. This failure of translational approaches indicates incomplete understanding underlying...