A5044138907- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Magnetic Properties and Synthesis of Ferrites
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Iron oxide chemistry and applications
- Advancements in Transdermal Drug Delivery
- Chalcogenide Semiconductor Thin Films
- Quantum Dots Synthesis And Properties
- Porphyrin and Phthalocyanine Chemistry
- Magnetic properties of thin films
- Graphene and Nanomaterials Applications
- Multiferroics and related materials
- Ionic liquids properties and applications
- Bee Products Chemical Analysis
- Nanoparticles: synthesis and applications
- Research on Leishmaniasis Studies
- Hemoglobin structure and function
- Physics of Superconductivity and Magnetism
- Carbon and Quantum Dots Applications
- Immune Response and Inflammation
- Characterization and Applications of Magnetic Nanoparticles
- Coffee research and impacts
- Magneto-Optical Properties and Applications
- Fungal Infections and Studies
Universidade de Brasília
2016-2025
Instituto Federal de Educação, Ciência e Tecnologia de Brasília
2024
Associação Brasileira de Oncologia Veterinária
2020
State University of Norte Fluminense
2019
Instituto de Física La Plata
2016
Universidade Federal de São Carlos
2003-2006
Universidade Estadual de Goiás
2006
In the photodynamic therapy (PDT), photosensitizer absorbs light and transfers energy of excited state to oxygen in cell environment producing reactive species (ROS), that its turn, may cause damage. photothermal (PTT), also is responsible for activating agent, which converts absorbed heat. Graphene oxide a carbon-based material presents activity. Its physical properties allow association with methylene blue consequently production ROS when submitted irradiation. Therefore, between...
Photodynamic therapy (PDT) combines light, molecular oxygen and a photosensitizer to induce oxidative stress in target cells. Certain hydrophobic photosensitizers, such as aluminium-phthalocyanine chloride (AlPc), have significant potential for antitumor PDT applications. However, molecules often require drug-delivery systems, nanostructures, improve their pharmacokinetic properties prevent aggregation, which has quenching effect on the photoemission aqueous media. As result, this work aims...
Background/Objectives: Curcumin has antimicrobial activity, and its mechanism of action involves changing histone acetylation. Our group shown that deacetylases (HDACs) inhibitors increase the sensibility Cryptococcus neoformans to certain antifungal treatments. Therefore, aim this work was investigate whether curcumin pretreatment increases effect photodynamic therapy (PDT) mediated by aluminum phthalocyanine in nanoemulsion (AlPc-NE) against C. neoformans. Methods: The minimum inhibitory...
In this study, we combined electron paramagnetic resonance (EPR) spectroscopy with an analysis of biophysical cellular parameters to study the mechanisms underlying in vitro anti-leishmanial activity miltefosine (MT). A thiol-specific spin label attached membrane-bound proteins Leishmania amazonensis and peritoneal macrophages indicated that MT may bind plasma membrane large quantities via a detergent-like action cause structural changes associated marked increase dynamics exposure aqueous...
An aggregation-induced emission enhancement (AIEE) effect in fluorescent lipophilic 2,1,3-benzothiadiazole (BTD) derivatives and their organic nanoaggregates were studied. A set of techniques such as single-crystal X-ray, dynamic light scattering (DLS), electron paramagnetic resonance (EPR), UV-vis, fluorescence, density functional theory (DFT) calculations have been used to decipher the formation/break (kinetics), properties, dynamics three BTD small molecules. in-depth study excited-state...
Photodynamic therapy (PDT) mediated by photosensitizers loaded in nanostructures as solid lipid nanoparticles has been pinpointed an effective and safe treatment against different skin cancers. Amazon butters have interesting composition when it comes to forming (SLN). In the present report, a new third-generation photosensitizing system consisting of aluminum-phthalocyanine associated with butter-based (SLN-AlPc) is described. The SLN was developed using murumuru butter, monodisperse...
We demonstrate air-stable copper-doped nanostructured borophosphate samples, which were prepared by a facile, low cost, and green synthesis method. The thermal annealing, in reducing hydrogen atmosphere, enables the formation of metallic copper nanostructures, was confirmed X-ray powder diffraction (XRD), scanning electron microscopy (SEM), optical absorption. spectra show main intense surface plasmon resonance (SPR) band centered at 579 nm. shapes morphology, thickness nanostructures...
Photodynamic therapy (PDT) uses a photosensitizer to generate reactive oxygen species (ROS) that kill target cells. In cancer treatments, PDT can potentially induce immunogenic cell death (ICD), which is characterized by well-controlled exposure of damage-associated molecular patterns (DAMPs) activate dendritic cells (DCs) and consequently modulate the immune response in tumor microenvironment. However, still has limitations, such as activity photosensitizers aqueous media poor...
Multicolor upconversion of SiO<sub>2</sub>-coated nanoparticles using for cells imaging and reactive oxygen species generation.
In this study Surface Enhanced Raman Spectroscopy (SERS) data recorded from mouse mammary glands cancer cells (4T1 cell line) was used to assess information regarding differences between control, death and viable after Photodynamic Therapy (PDT) treatment. The treatment nanoemulsions (NE/PS) loaded with different chloroaluminumphthalocyanine (ClAlP) photosensitizer (PS) contents (5 10 µmol × L-1) illumination (660 nm wavelength) at J cm-2 (10 minutes). SERS revealed significant molecular...
In the present study, iron oxide nanoparticles, in form of maghemite core coated with lauric acid (ION), were synthesized and loaded finasteride (FIN) or dutasteride (DUT) as a novel drug delivery system for topical treatment alopecia. Additionally, developed formulations (FIN-ION DUT-ION) completely elaborated components involved follicle metabolism, i.e., acid, which acts 5α-reductase inhibitor, deficiency has been related to hair loss aggravation. Stability assessment conducted over...
Melanoma, a severe form of skin cancer intricately linked to genetic and environmental factors, is predicted reach 100,000 new cases worldwide by 2040, underscoring the need for effective safe treatment options. In this study, we assessed efficacy photosensitizer called Chlorophyll A (Chl-A) incorporated into hydrogels (HGs) made chitosan (CS) poloxamer 407 (P407) Photodynamic Therapy (PDT) against murine melanoma cell line B16-F10. The HG was evaluated through various tests, including...
Cutaneous leishmaniasis (CL) is a neglected tropical disease. The treatment restricted to drugs, such as meglumine antimoniate and amphotericin B, that exhibit toxic effects, high cost, long-term treatment, limited efficacy. development of new alternative therapies, including the identification effective drugs for topical oral CL, great interest. In this sense, combination photodynamic therapy (PDT) with chloroaluminum phthalocyanine liposomes (Lip-ClAlPc) administration self-emulsifying...
Abstract The simple photolysis of CO 2 in aqueous solutions to generate and/or hydrocarbons and derivatives the presence a catalyst is considered be clean efficient approach for utilizing as C1 building block. Despite huge efforts dedicated this transformation using either semiconductors or homogeneous catalysts, only small improvements catalytic activity have been achieved so far. This article reports that organic salts—denominated ionic liquids—can efficiently photo‐reduce without...
Design, synthesis, molecular architecture and the unexpected behavior of fluorescent benzothiadiazole for selective mitochondrial plasma membrane staining are investigated.