A5085421328- Phytochemical compounds biological activities
- Photodynamic Therapy Research Studies
- Antimicrobial Peptides and Activities
- Endodontics and Root Canal Treatments
- Research on Leishmaniasis Studies
- Immune Response and Inflammation
- Nanoplatforms for cancer theranostics
- Insect and Pesticide Research
- Connexins and lens biology
- Mesenchymal stem cell research
- Drilling and Well Engineering
- Tissue Engineering and Regenerative Medicine
- Plant and animal studies
- Long-Term Effects of COVID-19
- Sperm and Testicular Function
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bat Biology and Ecology Studies
- Fungal Infections and Studies
- Chronic Lymphocytic Leukemia Research
- Insect Pest Control Strategies
- Dental Radiography and Imaging
- Wildlife Ecology and Conservation
- SARS-CoV-2 and COVID-19 Research
- Trypanosoma species research and implications
- Antibiotic Resistance in Bacteria
Universidade de Brasília
2019-2025
Background/Objectives: Curcumin has antimicrobial activity, and its mechanism of action involves changing histone acetylation. Our group shown that deacetylases (HDACs) inhibitors increase the sensibility Cryptococcus neoformans to certain antifungal treatments. Therefore, aim this work was investigate whether curcumin pretreatment increases effect photodynamic therapy (PDT) mediated by aluminum phthalocyanine in nanoemulsion (AlPc-NE) against C. neoformans. Methods: The minimum inhibitory...
Background: Paullinia cupana Kunth, popularly known as guarana, a native Amazonian shrub cultivated by the Sateré-Mawé ethnic group, has been used in traditional medicine for various purposes, including stimulant and therapeutic actions, due to its chemical composition, which is rich bioactive compounds. This study explored reductive potential of guarana with nanobiotechnology aimed synthesize silver nanoparticles (AgNPs) using aqueous extract leaves collected during dry rainy seasons,...
Photodynamic therapy (PDT) uses a photosensitizer to generate reactive oxygen species (ROS) that kill target cells. In cancer treatments, PDT can potentially induce immunogenic cell death (ICD), which is characterized by well-controlled exposure of damage-associated molecular patterns (DAMPs) activate dendritic cells (DCs) and consequently modulate the immune response in tumor microenvironment. However, still has limitations, such as activity photosensitizers aqueous media poor...
Leishmaniasis is a group of infectious diseases transmitted to humans during vector bites and caused by protozoans the genus
Abstract Host Defense Peptides (HDPs) have, in previous studies, been demonstrating antimicrobial, anti-inflammatory, and immunomodulatory capacity, important factors the repair process. Knowing these characteristics, this article aims to evaluate potential of HDPs IDR1018 DJK-6 associated with MTA extract process human pulp cells. Antibacterial activity HDPs, combined Streptococcus mutans planktonic bacteria antibiofilm was evaluated. Cell toxicity assayed MTT cell morphology observed by...
Tuberculosis remains a serious global health threat, exacerbated by the rise of resistant strains. This study investigates potential two benzofuroxan ( Bfx ) derivatives, 5n and 5b, as targeted treatments for MDR-TB using in silico , vitro vivo methodologies. In analyses showed that compounds have significant activity against Mtb H37Rv, with standing out MIC 90 0.09 ± 0.04 μM. Additionally, their efficacy MDR pre-XDR strains was superior compared to commercial drugs. These narrow spectrum...
The global impact of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic in 2019-2020 has led to significant changes worldwide vaccination and immune prophylactic approaches. In this study, our research delves into a new immunization strategy that does not involve use additional adjuvants or preservatives, focusing on effects virus fusion with bacterial nanostructure. experimental procedures outlined paper involved cultivation SARS-CoV-2, production, extraction,...
Diphylla ecaudata is a hematophagous bat endemic of South America, with food preference for bird blood. Given the lack information about reproductive activity this species, study aimed to describe testicular morphology and histomorphometry D. in order understand its biology, specially spermatogenesis. The animals were collected Lajes city, Rio Grande do Norte, Brazil. Following euthanasia, testes histologically processed morphological, morphometric, ultrastructural immunohistochemical...
The culture of mesenchymal stem cells (MSCs) as spheroids promotes a more physiological cellular behavior, it accurately reflects the biological microenvironment. Nevertheless, mixed results have been found regarding immunosuppressive properties spheroid-cultured MSCs (3D-MSCs), mechanisms immunoregulation 3D-MSCs being scarcely described at this point. In present study, we constructed from and compared their potential with that cultured in monolayer (2D-MSCs). First, evaluated ability...
The study investigated midpiece defects in sperm from a 5-year-old Brangus bull with high rate of semen batch rejection, due to morphologically abnormal sperm, no reduction kinematics. A comprehensive evaluation was conducted over 16-month period, involving 28 ejaculates. Notably, despite the proportion (average 37.73%, 3% 58%), revealed stable production, discernible differences kinematic data before and after cryopreservation. Electron microscopy identified discontinuities mitochondrial...
Ibrutinib (IB) is a tyrosine kinase inhibitor (TKI) that has immunomodulatory action and can be used as second-line therapy for steroid-refractory or steroid-resistant chronic Graft versus Host Disease (cGVHD). Mesenchymal stromal cells (MSCs) are distributed throughout the body their infusion also been explored therapeutic alternative treatment of cGVHD. Considering currently unknown effects IB on endogenous MSCs, well possible combined use MSCs cGVHD, we investigated whether adipose...
This study aimed to present a case series of refractory endodontic treatment leading persistent apical periodontitis. All cases were submitted scanning electron microscopic/energy-dispersive X-ray analysis (SEM/EDS) the external surface surgically removed samples and identification elements in specimens. Carbon, oxygen calcium all this study. The presence microorganisms close contact with periapical surrounding tissues induced perpetuation inflammation process. Despite other different from...