A5101535332- Tuberculosis Research and Epidemiology
- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Cancer therapeutics and mechanisms
- Crystallization and Solubility Studies
- Mycobacterium research and diagnosis
- Synthesis and biological activity
- Crystal structures of chemical compounds
- Natural product bioactivities and synthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Antimicrobial agents and applications
- Antibiotic Resistance in Bacteria
- Drug Solubulity and Delivery Systems
- Carcinogens and Genotoxicity Assessment
- Peptidase Inhibition and Analysis
- Sesquiterpenes and Asteraceae Studies
- Crystallography and molecular interactions
- Plant Toxicity and Pharmacological Properties
- Curcumin's Biomedical Applications
- Diagnosis and treatment of tuberculosis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Organoboron and organosilicon chemistry
- Research on Leishmaniasis Studies
- Diphtheria, Corynebacterium, and Tetanus
- Advanced Drug Delivery Systems
Universidade Estadual Paulista (Unesp)
2016-2025
Instituto de Ciências Farmacêuticas
2018-2020
Centro Universitário de Araraquara
2015-2019
Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis. Cessation of treatment before the recommended conclusion may lead to emergence multidrug-resistant strains. The aim this study was develop nanostructured lipid carriers (NLCs) for use in M. NLCs comprised following phase: 2.07% polyoxyethylene 40 stearate, 2.05% caprylic/capric triglyceride, and 0.88% polyoxyl hydrogenated castor oil; aqueous 3.50% poloxamer 407 (F1-F6), 0.50% cetyltrimethylammonium bromide (F7-F12);...
Organoboron compounds, especially those containing boronic acid and benzoxaborole in their structure, have been gaining prominence medicinal chemistry, following the FDA approval of tavaborole for treatment onychomycosis bortezomib multiple myeloma. The antimicrobial anticancer effects organoboron compounds motivate investigation novel derivatives described here. A total fourteen new were synthesized characterized using analytical methods. activities evaluated against M. tuberculosis (Mtb)...
Mycobacterium tuberculosis is the etiologic agent of tuberculosis. The demand for new chemotherapeutics with unique mechanisms action to treat (multi)resistant strains an urgent need. objective this work was test effect manganese(II) and copper(II) phenanthroline/dicarboxylate complexes against M. water-soluble Mn(II) complexes, [Mn2(oda)(phen)4(H2O)2][Mn2(oda)(phen)4(oda)2]·4H2O (1) {[Mn(3,6,9-tdda)(phen)2]·3H2O·EtOH}n (3) (odaH2 = octanedioic acid, phen 1,10-phenanthroline, tddaH2...
Helicobacter pylori inhabits the gastric epithelium and can promote development of disorders, such as peptic ulcers, acute chronic gastritis, mucosal lymphoid tissue (MALT), adenocarcinomas. To use nanotechnology a tool to increase antibacterial activity silver I [Ag(I)] compounds, this study suggests new strategy for H. infections, which have hitherto been difficult control. [Ag (PhTSC·HCl)2] (NO3)·H2O (compound 1) was synthesized, characterized, loaded into polymeric nanoparticles (PN1)....
Fe(<sc>iii</sc>)-Aminobisphenolate hydroxyquinoline complexes are active anticancer drug candidates in the low micromolar range, displaying apoptosis as mode of cell death.
Abstract Tuberculosis (TB) is currently the leading cause of death related to infectious diseases worldwide, as reported by World Health Organization. Moreover, increasing number multidrug‐resistant tuberculosis (MDR‐TB) cases has alarmed health agencies, warranting extensive efforts discover novel drugs that are effective and also safe. In this study, 23 new compounds were synthesized evaluated in vitro against drug‐resistant strains M. . The compound...
In this paper we continue our efforts in the search for new Schiff bases as resveratrol analogues promising antitubercular and antileishmanial agents.Compounds were evaluated vitro against Mycobacterium tuberculosis Leishmania species.Compounds showed varying activity promastigotes of all species tested (concentration leading to reduction 50% parasite growth-IC 50 values ranging from 1.60 15.53 µg mL -1 ).Majority compounds exhibited good results with IC below 10.00 , no cytotoxicity...
A copper(II) complex-loaded castor oil-based nanostructured lipid carrier was evaluated to enhance the poor water solubility of antimicrobial compounds, improving their biological properties and activity against Mycobacterium tuberculosis. Nanostructured carriers were composed oil, polyoxyethylene 40 stearate caprylic/capric triglyceride, poloxamer 407, cetyltrimethylammonium bromide three different complexes. The systems ultrasonicated at an amplitude 8% for 20 min ice bath used throughout...
The emergence of multidrug-resistant strains M. tuberculosis has raised concerns due to the greater difficulties in patient treatment and higher mortality rates. Herein, we revisited 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine scaffold identified potent new carbamate derivatives having MIC
In view of the biological activities and growing therapeutic interest in oleoresin obtained from Copaifera multijuga, this study aimed to determine genotoxic antigenotoxic potential (CMO) its chemical marker, diterpene (-)-copalic acid (CA). The micronucleus (MN) assay V79 cell cultures Ames test were used for vitro analyses, as well MN comet assays Swiss mice vivo analyses. genotoxicity/mutagenicity results showed that either CMO (30, 60, or 120 µg/ml-MN assay; 0.39-3.12 mg/plate-Ames test)...
Tuberculosis remains a serious global health threat, exacerbated by the rise of resistant strains. This study investigates potential two benzofuroxan ( Bfx ) derivatives, 5n and 5b, as targeted treatments for MDR-TB using in silico , vitro vivo methodologies. In analyses showed that compounds have significant activity against Mtb H37Rv, with standing out MIC 90 0.09 ± 0.04 μM. Additionally, their efficacy MDR pre-XDR strains was superior compared to commercial drugs. These narrow spectrum...
Copaifera langsdorffii Desf. is a plant found in South America, especially Brazil. Oleoresin and the leaves of this used as popular medicinal agent. However, few studies on chemical composition aerial parts related biological activities are known. This study aimed to examine cytotoxic, genotoxic, antigenotoxic potential C. hydroalcoholic extract (CLE) two its major compounds afzelin quercitrin. The cytotoxic CLE was determined follows: 1) against genotoxicity induced by doxorubicin (DXR) or...
As a biologic reservoir of Mycobacterium tuberculosis (M. tb), one-quarter the world population is infected with well-known latent (LTBI). About 5–10% LTBI patients will progress to active disease in first years after primary infection and, despite using recommended treatment, 20% can still reactivate infection. A new treatment could minimize adverse effects and antibiotic resistance that occur when same drug used treat disease. New hydrazones were evaluated, they showed great inhibitory...
This study aimed to encapsulate and characterise a potential anti-tuberculosis copper complex (CuCl2(INH)2.H2O:I1) into polymeric nanoparticles (PNs) of polymethacrylate copolymers (Eudragit®, Eu) developed by nanoprecipitation method. NE30D, S100 and, E100 polymers were tested. The physicochemical characterisations performed DLS, TEM, FTIR, encapsulation efficiency in vitro release studies. Encapsulation I1 PN-NE30D, PN-E100, PN-S100 was 26.3%, 94.5%, 22.6%, respectively. particle size zeta...