A5029999473- Antibiotic Resistance in Bacteria
- Cannabis and Cannabinoid Research
- Tuberculosis Research and Epidemiology
- Polyamine Metabolism and Applications
- Cancer therapeutics and mechanisms
- Phenothiazines and Benzothiazines Synthesis and Activities
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
Universidade de São Paulo
2021-2024
Universidade de Ribeirão Preto
2021-2024
Abstract This study aimed to assess the ultrapure cannabidiol (CBD) antibacterial activity and investigate of combination CBD + polymyxin B (PB) against Gram-negative (GN) bacteria, including PB-resistant bacilli (GNB). We used standard broth microdilution method, checkerboard assay, time-kill assay. exhibited Gram-positive lipooligosaccharide (LOS)-expressing GN diplococcus (GND) ( Neisseria gonorrhoeae , meningitidis Moraxella catarrhalis ), Mycobacterium tuberculosis but not GNB. For most...
Tuberculosis remains a serious global health threat, exacerbated by the rise of resistant strains. This study investigates potential two benzofuroxan ( Bfx ) derivatives, 5n and 5b, as targeted treatments for MDR-TB using in silico , vitro vivo methodologies. In analyses showed that compounds have significant activity against Mtb H37Rv, with standing out MIC 90 0.09 ± 0.04 μM. Additionally, their efficacy MDR pre-XDR strains was superior compared to commercial drugs. These narrow spectrum...
Abstract Multidrug-resistant (MDR) and extensively drug-resistant (XDR) bacteria are a major worldwide public health problem. In the last decades, resistance to last-resort antibiotics such as polymyxin B (PB) have been increasingly observed among these superbugs, compromising effectiveness of antimicrobial therapy. The present study aimed (i) assess ultrapure Cannabidiol (CBD) antibacterial activity against broad diversity Gram-negative (GN) Gram-positive (GP) (44 different species, 95...