A5067936895- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Antioxidant Activity and Oxidative Stress
- Essential Oils and Antimicrobial Activity
- Viral gastroenteritis research and epidemiology
- Biomedical and Engineering Education
- Bone health and treatments
- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- SARS-CoV-2 detection and testing
- Nanoparticles: synthesis and applications
- Biochemical and biochemical processes
- Radiopharmaceutical Chemistry and Applications
- Ionic liquids properties and applications
- Entrepreneurship Studies and Influences
- Diverse Scientific Research Studies
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Medicinal Plants
- Lipid Membrane Structure and Behavior
- Biotechnology and Related Fields
- Curcumin's Biomedical Applications
- Porphyrin and Phthalocyanine Chemistry
Universidade de Brasília
2018-2025
This study explores the development and characterization of lipid nanostructures (NLCs) containing natural deep eutectic solvents (NaDES) derived from taperebá peel extract (Spondias mombin), a by-product rich in bioactive phenolic compounds, including ellagic acid quercetin. The exhibited high polyphenol content (2623 mg GAE/L) notable antioxidant activity, as demonstrated by DPPH (258 mM TEAC/100 mL) ABTS (495 assays. NLCs were developed using NaDES to enhance stability bioavailability...
This study explores the development and characterization of lipid nanostructures (NLCs) containing natural deep eutectic solvents (NaDESs) derived from taperebá peel extract (Spondias mombin), a by-product rich in bioactive phenolic compounds, including ellagic acid quercetin. The exhibited high polyphenol content (2623 mg GAE/L) notable antioxidant activity, as demonstrated by DPPH (258 mM TEAC/100 mL) ABTS (495 assays. NLCs were developed using NaDESs to enhance stability bioavailability...
Photodynamic therapy (PDT) uses a photosensitizer to generate reactive oxygen species (ROS) that kill target cells. In cancer treatments, PDT can potentially induce immunogenic cell death (ICD), which is characterized by well-controlled exposure of damage-associated molecular patterns (DAMPs) activate dendritic cells (DCs) and consequently modulate the immune response in tumor microenvironment. However, still has limitations, such as activity photosensitizers aqueous media poor...
The industries are searching for greener alternatives their productions due to the rising concern about environment and creation of waste by-products without industrial utility that specific line products. This investigation describes development two stable nanostructured lipid carriers (NLCs): one is formulation a standard NLC, other same NLC associated with natural deep eutectic solvent (NaDES). research presents paths NLCs through completeness, which encompass dynamic light scattering...
Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro analyzed by confocal microscopy. Results: Stable high curcumin-loading capacity were obtained. more toxic CT26 than free curcumin. Fluorescence microscopy images showed the be taken up vitro. Conclusion: These results indicate that are suitable...
The use of photodynamic therapy (PDT) and development novel photosensitizers (PSs) for cancer treatment have received more attention nowadays. In the present work, five benzo[a]phenoxazinium derivatives been prepared evaluated their in vitro anticancer activity first time. They are red light absorbers show low fluorescence quantum yield. Of these compounds, PS4 exhibited a higher yield reactive oxygen species (ROS) generation. assays with cells showed that PS1 were not significantly toxic...
The efficacy and safety of photodynamic therapy (PDT) have drawn much attention from clinicians researchers in the field anticancer treatments since last century. Despite numerous positive outcomes, works on PDT brought to light over decades, room remains for improvements tools, mainly photosensitizer molecules. This work reports first experiments evidencing photosensitizing activity DHX-1, a xanthene derivative-based near-infrared probe recently described literature, both as free molecule...
A new coronavirus, identified in Wuhan, China, has spread globally, infecting millions of people and causing significant morbidity mortality. The pandemic state, declared by the World Health Organization on March 11, 2020, transformed world made adapt to social distance control virus. race against time search therapeutic solutions become essential, nanotechnology may be able make vaccines available record stimulate immunization individuals. Since beginning scientists companies are rapidly...
The increase in cases admitted under atypical pneumonia Wuhan surprised local public health December 2019. cause of the clinical condition was associated with a new coronavirus. Despite efforts to control situation this etiologic agent, virus spread throughout world and pandemic state declared on March 11, 2020, by World Health Organization (WHO). This study aims provide comprehensive up-to-date overview 2019 coronavirus disease, presented comparative other viruses same family, diagnosis,...
Breast cancer and its metastases involve high mortality even with advances in chemotherapy. Solid lipid nanoparticles provide a platform for drug delivery, reducing side effects treatment-induced bone loss. A solid nanoparticle containing doxorubicin was evaluated ability to prevent loss pre-clinical breast model.
A bioeconomia atrela o desenvolvimento sustentável a inovações biotecnológicas. nanotecnologia pode ser uma aliada por meio do uso consciente da biodiversidade, particularmente na produção de nanocosméticos. pesquisa em bases patentárias auxilia no esclarecimento contexto tecnológico área e direcionar cadeia produtiva relacionada. Este trabalho objetivou realizar prospecção patentária diferentes avaliar as tendências setor, alinhando avanço dos nanocosméticos aos preceitos bioeconômicos....
The new coronavirus pandemic brought the need for researchers to work tirelessly in search therapies or vaccines that would allow control of spread virus around world. Fortunately there are two RNA against COVID-19 have finished clinical tests and approved some countries. They first third generation history time record. But still concerns about safety DNA/RNA vaccines. Here we bring a discussion DNA/RNA: can these be integrated genome? In fact, DNA an infinite chance integrate cell's genome,...
Objective: Cancer is still a complex and debilitating disease even though advances in treatment have occurred. Triplenegative breast cancer (TNBC) an aggressive subtype of with poor prognosis occurs more frequently young women. Due to its metastatic features unique tumor microenvironment, TNBC limited. In this study, we evaluated how three chemotherapy drugs could be used produce vaccines cells under immunogenic cell death. Methodology: For that, 4T1-luc2 were treated cisplatin (100 μM),...
El estado de pandemia, declarado por la Organización Mundial Salud, el 11 marzo 2020, ha puesto a prueba capacidad adaptación y respuesta sociedad. Una carrera contra tiempo para buscar estrategias combatir enfermedad del nuevo coronavirus contribuye unión los científicos todo mundo, incluyendo uso nanotecnología. Por lo tanto, objetivo estudio fue describir panorama las nanotecnología COVID-19, destacando principalmente productos diagnósticos, vacunas tratamientos que son o pueden ser...