A5024832708- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Microfluidic and Bio-sensing Technologies
- Cancer, Lipids, and Metabolism
- Nanoparticles: synthesis and applications
- Cancer Research and Treatment
- Circadian rhythm and melatonin
- Porphyrin and Phthalocyanine Chemistry
- Angiogenesis and VEGF in Cancer
- Nuclear Structure and Function
- Microtubule and mitosis dynamics
- Thermoregulation and physiological responses
- Iron Metabolism and Disorders
- Photodynamic Therapy Research Studies
- Adipose Tissue and Metabolism
- Ultrasound and Hyperthermia Applications
- Metabolomics and Mass Spectrometry Studies
- Bone health and treatments
- Radiopharmaceutical Chemistry and Applications
- Mathematical Biology Tumor Growth
- Orthopaedic implants and arthroplasty
Universidade de Brasília
2019-2024
Magnetic nanoparticles (MNPs) have been successfully tested for several purposes in medical applications. However, knowledge concerning the effects of nanostructures on elderly organisms is remarkably scarce.To fill part this gap, work aimed to investigate biocompatibility and bio-distribution aspects magnetic coated with citrate (NpCit) both young healthy mice.NpCit (2.4 mg iron) was administered intraperitoneally, its toxicity evaluated 28 days through clinical, biochemical, hematological,...
Aim: Investigate the heterogeneous tumor tissue organization and examine how this condition can interfere with passive delivery of a lipid nanoemulsion in two breast cancer preclinical models (4T1 Ehrlich). Materials & methods: The authors used vivo image techniques to follow biodistribution microtomography, as well traditional histopathology electron microscopy evaluate structural characteristics. Results conclusion: Lipid was delivered tumor, vascular depends upon subtumoral localization...
Aim: Nano-5-aminolevulic acid (NanoALA)-mediated photodynamic therapy (PDT), an oil-in-water polymeric nanoemulsion of ALA, was evaluated in a murine model breast cancer. Materials & methods: Analysis ALA-derived protoporphyrin IX production and acute toxicity test, biocompatibility treatment efficacy, long-term effect NanoALA-PDT on tumor progression were performed. Results: The nanoformulation favored the prodrug uptake by cells shorter time (1.5 h). As result, adverse effects negligible...
Nanobiotechnology strategies for cancer treatments are currently being tested with increasing interest, except in elderly groups. It is well established that breast incidence increases age and traditional therapies usually generate severe adverse effects, especially To investigate if the benefits of nanotechnology could be extended to treating this group, citrate-coated maghemite nanoparticles (NpCit) were used magnetohyperthermia (MHT) combination administration PLGA-Selol nanocapsule...
Short time treatment with reduced dosages of selol-loaded PLGA nanocapsules (NcSel) combined magnetic hyperthermia (MHT) is evaluated in aged Erhlich tumor-bearing mice. Clinical, hematological, biochemical, genotoxic and histopathological parameters are assessed during 7 d NcSel MHT, separately or combined. The evolution the tumor volume successfully modeled using logistic mathematical model. therapy comprising MHT able to hinder primary growth a case complete remission recorded. Moreover,...
Breast cancer and its metastases involve high mortality even with advances in chemotherapy. Solid lipid nanoparticles provide a platform for drug delivery, reducing side effects treatment-induced bone loss. A solid nanoparticle containing doxorubicin was evaluated ability to prevent loss pre-clinical breast model.
Breast cancer is a group of malignancies most common among women. In 2018, approximately 2.1 million women were diagnosed, with 626,679 deaths. The traditional classification these diseases based on the extent illness (in situ or invasive), affected tissue (epithelial for instance), and site occurrence (duct lobe). invasive ductal carcinoma type. molecular characteristics divides breast into at least five groups: Luminal A, B, negative HER-2, positive triple negative, being aggressive...