A5051387626- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Fatty Acid Research and Health
- Lipid metabolism and biosynthesis
- Inflammasome and immune disorders
- Cancer, Lipids, and Metabolism
- Nanoparticle-Based Drug Delivery
- Ultrasound and Hyperthermia Applications
- Cancer Risks and Factors
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cardiovascular Disease and Adiposity
- Cancer, Stress, Anesthesia, and Immune Response
- Lipid metabolism and disorders
- Immune cells in cancer
- Blood transfusion and management
- Nanoparticles: synthesis and applications
- Erythrocyte Function and Pathophysiology
- Wound Healing and Treatments
- Blood properties and coagulation
- Iron Metabolism and Disorders
- Tendon Structure and Treatment
- Exercise and Physiological Responses
- Periodontal Regeneration and Treatments
- IL-33, ST2, and ILC Pathways
University of Münster
2023
Universidade de Brasília
2017-2020
Biogen (United States)
2019
University School
2019
Case Western Reserve University
2019
The implication of inflammation in pathophysiology several type cancers has been under intense investigation. Omega-3 fatty acids can modulate and present anticancer effects, promoting cancer cell death. Pyroptosis is an related death so far, the function docosahexaenoic acid (DHA) pyroptosis not described. This study investigated role DHA triggering activation breast cells. MDA-MB-231 cells were supplemented with was analyzed. DHA-treated triggered increased caspase-1and gasdermin D...
Foam cells are specialized lipid-loaded macrophages derived from monocytes and a key pathological feature of atherosclerotic lesions. Lysophosphatidylcholine (LPC) is major lipid component the plasma membrane with broad spectrum proinflammatory activities plays role in atherosclerosis. However, LPC droplet (LD) biogenesis modulation inflammasome activation still poorly understood. In present study, we investigated whether can induce foam cell formation through an analysis LD determined...
Omega 3-docosahexaenoic acid (DHA) and vitamin E Delta-tocotrienol (Delta-T3) are extensively studied as protective nutrients against cancer development. Little is known about the biological mechanisms targeted by these bioactive molecules on lipid droplet (LD) biogenesis, an important breast aggressiveness marker, occurrence of lipophagy in cells. The aim this study was to investigate effect DHA, Delta-T3 DHA plus co-treatment LD biogenesis process triple negative cell line MDA-MB-231....
Negatively charged microspheres (NCMs) represent a new therapeutic approach for wound healing since recent clinical trials have shown NCM efficacy in the recovery of hard-to-heal wounds that tend to stay inflammatory phase, unlocking process. The aim this study was elucidate mechanism action. NCMs were extracted from commercial microsphere formulation (PolyHeal® Micro) and cytotoxicity, attachment, proliferation viability assays performed keratinocytes dermal fibroblasts, while macrophages...
Magnetic nanoparticles (MNPs) have been successfully tested for several purposes in medical applications. However, knowledge concerning the effects of nanostructures on elderly organisms is remarkably scarce.To fill part this gap, work aimed to investigate biocompatibility and bio-distribution aspects magnetic coated with citrate (NpCit) both young healthy mice.NpCit (2.4 mg iron) was administered intraperitoneally, its toxicity evaluated 28 days through clinical, biochemical, hematological,...
Nanobiotechnology strategies for cancer treatments are currently being tested with increasing interest, except in elderly groups. It is well established that breast incidence increases age and traditional therapies usually generate severe adverse effects, especially To investigate if the benefits of nanotechnology could be extended to treating this group, citrate-coated maghemite nanoparticles (NpCit) were used magnetohyperthermia (MHT) combination administration PLGA-Selol nanocapsule...
Abstract Efficient recruitment of circulating immune cells to various tissues plays a critical role in homeostasis and surveillance, process that serves as the basis any successful cell-based immunotherapeutic strategies cancer, particularly for solid tumors cancers residing body sites outside blood vessels sinusoid network. Clinical experimental observations suggest vivo leukocyte adhesion extravasation are maximal near transition from capillary post-capillary venule, through multistep...