A5101814653- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Inflammasome and immune disorders
- Digestive system and related health
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Virology and Viral Diseases
- Pituitary Gland Disorders and Treatments
- Neutropenia and Cancer Infections
- Fungal Infections and Studies
- Sperm and Testicular Function
- Cell death mechanisms and regulation
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Photodynamic Therapy Research Studies
- Diet and metabolism studies
- Infections and bacterial resistance
- Amoebic Infections and Treatments
- Chronic Disease Management Strategies
- Neuroendocrine Tumor Research Advances
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cancer Risks and Factors
- Employee Performance and Management
- Diagnosis and treatment of tuberculosis
- COVID-19 Impact on Reproduction
Universidade de Brasília
2013-2022
Hospital Beatriz Ângelo
2013-2021
Hospital for Sick Children
2008
SickKids Foundation
2008
Foam cells are specialized lipid-loaded macrophages derived from monocytes and a key pathological feature of atherosclerotic lesions. Lysophosphatidylcholine (LPC) is major lipid component the plasma membrane with broad spectrum proinflammatory activities plays role in atherosclerosis. However, LPC droplet (LD) biogenesis modulation inflammasome activation still poorly understood. In present study, we investigated whether can induce foam cell formation through an analysis LD determined...
Paracoccidioides brasiliensis is the etiologic agent of paracoccidioidomycosis (PCM), most prevalent systemic mycosis that geographically confined to Latin America. The pro-inflammatory cytokine IL-1β mainly derived from activation cytoplasmic multiprotein complex inflammasome an essential host factor against opportunistic fungal infections; however, its role in infection with a primary pathogen, such as P. brasiliensis, not well understood. In this study, we found murine bone marrow-derived...
Photodynamic therapy (PDT) mediated by photosensitizers loaded in nanostructures as solid lipid nanoparticles has been pinpointed an effective and safe treatment against different skin cancers. Amazon butters have interesting composition when it comes to forming (SLN). In the present report, a new third-generation photosensitizing system consisting of aluminum-phthalocyanine associated with butter-based (SLN-AlPc) is described. The SLN was developed using murumuru butter, monodisperse...
Abstract Zika virus (ZIKV) has a strong tropism for the nervous system and been related to post-infection neurological syndromes. Once neuronal cells are infected, is capable of modulating cell metabolism, leading neurotoxicity cellular death. The negative effect ZIKV in neuron characterized. However, description molecules reversing these cytotoxic effects still under investigation. In this context, it largely demonstrated that docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty...
Obesity is a chronic disease with rising worldwide prevalence and largely associated several other comorbidities, such as cancer, nonalcoholic fatty liver (NAFLD) metabolic syndrome. Hepatic steatosis, hallmark of NAFLD, strongly correlated obesity has been changes in the gut microbiota, which can promote its development through production short-chain acids (SCFAs) that regulate insulin resistance, bile acid, choline metabolism, inflammation. Recent studies have suggested controversial role...
Klebsiella pneumoniae invasive syndrome (KPIS) is a rare clinical condition characterized by primary liver abscess associated with metastatic infection. Most case reports are from Southeast Asia, only one described in Portugal. The Authors present the of 44-year-old man history fever, dry cough and cervicalgia. A thoracic computed tomography (CT) scan showed multiple pulmonary hepatic nodules, suggestive malignancy. Both blood cultures bronchoalveolar lavage were positive for pneumoniae....
The genetic alphabet consists of the four letters: C, A, G, and T in DNA C,A,G, U RNA. Triplets these letters jointly encode 20 different amino acids out which proteins all organisms are built. This system is universal found kingdoms life. However, bases RNA can be chemically modified. In DNA, around 10 modifications known, those have been studied intensively over past years. Scientific studies on that recognize them gave rise to large field epigenetic epigenomic research. outcome this...
Gut microbiota composition can modulate neuroendocrine function, inflammation, and cellular immunological responses against different pathogens, including viruses. Zika virus (ZIKV) infect adult immunocompetent individuals trigger brain damage antiviral responses. However, it is not known whether ZIKV infection could impact the gut microbiome from mice. Here, we investigated modifications induced by in of C57BL/6J Adult mice were infected with was analyzed next-generation sequencing V4...
Zika virus (ZIKV) infection has been associated with prolonged viral excretion in human semen and causes testicular atrophy infertility 10-week-old immunodeficient mice. Male IFNAR−/− mice, knockout for type I interferon receptor, were immunized GLS-5700, a deoxyribonucleic acid-based vaccine, before subcutaneous ZIKV challenge 6 × 105 plaque-forming units at 13 weeks of age. On day 28 postinfection, testes epididymides collected some mice histological functional analyses, whereas others...
Immune thrombocytopenia (ITP) related to Mycoplasma pneumoniae infection is a rare condition and usually associated with severe clinical course. We here report case of young man diagnosis ITP secondary M. infection. The features, therapy outcome are presented.
Diffuse alveolar haemorrhage related to an anti-neutrophil cytoplasmic antibody (ANCA)-associated small vessel vasculitis is extremely rare form of presentation breast cancer. Here we report the case a 77-year-old woman with histological diagnosis papillary ductal carcinoma presenting diffuse secondary perinuclear ANCA-associated vasculitis. To our knowledge, this first ever reported as The therapeutic approach paraneoplastic included use corticosteroids and plasmapheresis, very useful...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)