A5011569285- Liver Disease Diagnosis and Treatment
- Reproductive Biology and Fertility
- Advanced Proteomics Techniques and Applications
- Sperm and Testicular Function
- Gut microbiota and health
- Marine animal studies overview
- Cancer, Lipids, and Metabolism
- Reproductive Physiology in Livestock
- Palliative and Oncologic Care
- Cardiovascular Disease and Adiposity
- Metabolomics and Mass Spectrometry Studies
- Liver Disease and Transplantation
- Calcium signaling and nucleotide metabolism
- Biomarkers in Disease Mechanisms
- Coral and Marine Ecosystems Studies
- Phytochemistry Medicinal Plant Applications
- Colorectal Cancer Screening and Detection
- Hepatitis C virus research
- Trypanosoma species research and implications
- Retinal Diseases and Treatments
- Psychology and Mental Health
- Mosquito-borne diseases and control
- Education Pedagogy and Practices
- Cardiac Imaging and Diagnostics
- Simulation-Based Education in Healthcare
Scripps Research Institute
2024
Universidade de Brasília
2016-2024
Universidad San Pablo CEU
2019-2024
Universidad San Pablo
2023
University Center of Brasília
2021-2022
Hospital do Coração
2022
National Council for Scientific and Technological Development
2018-2019
Universidad de Oriente
2018-2019
Serviço Nacional de Aprendizagem Comercial
2018-2019
Universidade Federal do Ceará
2011-2019
Abstract Male fertility is the ability of sperm to fertilize egg and sustain embryo development. Several factors determine fertilizing capacity mammalian sperm, including those intrinsic components seminal plasma. The present study analyzed fluid proteome Bos taurus potential associations between proteins scores. Mass spectrometry coupled with nano HPLC allowed identification 1,159 in dairy bull There were 50 29 more abundant high (HF) low (LF) bulls, respectively. Based on multivariate...
"O câncer é uma das principais causas de morte em animais, responsável por 50% dos óbitos animais acima 10 anos. O hemangiossarcoma um tipo agressivo neoplasia originada vasos sanguíneos, afetando principalmente cães, machos, meia-idade a idosos, sendo comum raças grandes. prognóstico reservado, com sobrevida curta. A nutrição exerce papel crucial junto ao paciente oncológico, dieta adequada parte da estratégia terapêutica. Opresente trabalhovisarelataro manejo nutricional adotado nocaso...
Gut microbiota profiles are closely related to cardiovascular diseases through mechanisms that include the reported deleterious effects of metabolites, such as trimethylamine N-oxide (TMAO), which have been studied diagnostic and therapeutic targets. Moderate red wine (RW) consumption is reportedly cardioprotective, possibly by affecting gut microbiota.To investigate RW on microbiota, plasma TMAO, metabolome in men with documented coronary artery disease (CAD) using a multiomics assessment...
This study reviews and updates information on cetacean strandings in the state of Ceará, Brazil (02°30′S 41°15′W– 04°30′S 36°45′W), comprising 573 km coastline. In years 1992–2005, there were 252 stranding events, representing 19 species: three species Balaenopteridae, Physeteridae, two Kogiidae, Ziphiidae 11 Delphinidae. Three comprised majority (78.9%) events: estuarine dolphin, Sotalia guianensis (61.9%); sperm whale, Physeter macrocephalus (10.3%); rough-toothed Steno bredanensis (6.7%)....
Obesity is a chronic disease with rising worldwide prevalence and largely associated several other comorbidities, such as cancer, nonalcoholic fatty liver (NAFLD) metabolic syndrome. Hepatic steatosis, hallmark of NAFLD, strongly correlated obesity has been changes in the gut microbiota, which can promote its development through production short-chain acids (SCFAs) that regulate insulin resistance, bile acid, choline metabolism, inflammation. Recent studies have suggested controversial role...
Abstract The present study was conducted to decipher the proteome of in vivo‐produced pre‐implantation ovine embryos. Ten locally adapted Morana Nova ewes received hormonal treatment and were inseminated 12 hr after ovulation. Six days later, 54 embryos (morula blastocyst developmental state) recovered from eight pooled obtain sufficient protein for proteomic analysis. Extracted embryo proteins analysed by LC‐MS/MS, followed identification based on four database searches (PEAKS, Proteome...
Cervical cancer is the fourth most common neoplasia in women and infection with human papilloma virus (HPV) its necessary cause. Screening methods, currently based on cytology HPV DNA tests, display low specificity/sensitivity, reducing efficacy of cervical screening programs. Herein, molecular signatures cytologic specimens revealed by liquid chromatography-mass spectrometry (LC-MS), were tested their ability to provide a metabolomic for cancer. These molecules whether they could clinically...
Age-related macular degeneration (AMD) is among the world's leading causes of blindness. In its neovascular form (nAMD), around 25% patients present further anatomical and visual deterioration due to persistence activity, despite gold-standard treatment protocols using intravitreal anti-VEGF medications. Thus, comprehend, molecular pathways that drive choroidal neoangiogenesis, associated with vascular endothelial growth factor (VEGF), are important steps elucidate mechanistic events...
Echocardiographic markers associated with asymptomatic acute cellular rejection (ACR) in patients orthotopic heart transplant (HT) are still under investigation. The aim of our study was to determine clinical and myocardial strain imaging (MSI) variables evaluated by echocardiography ACR the first year HT. A separate analysis performed compare during 6 months HT, when has a prevalence 60% patients. Another an exclusive population Chagas disease as cause HT.We prospectively studied 67 less...
Single-cell proteomics has emerged as a powerful technology for unraveling the complexities of cellular heterogeneity, enabling insights into individual cell functions and pathologies. One primary challenges in single-cell is data generation, where low mass spectral signals often preclude triggering MS2 events. This challenge addressed by Data Independent Acquisition (DIA), acquisition strategy that does not depend on peptide ion isotopic signatures to generate an event. In this study, we...
Abstract Heart failure (HF) studies typically focus on ischemic and idiopathic heart diseases. Chronic chagasic cardiomyopathy (CCC) is a progressive degenerative inflammatory condition highly prevalent in Latin America that leads to disturbance of cardiac conduction system. Despite its clinical epidemiological importance, CCC molecular pathogenesis poorly understood. Here we characterize discriminate the plasma metabolomic profile 15 patients with advanced HF referred for transplantation –...
Keywords: methylmercury, ApoE, epididymal white fat, metabolomics, dyslipidemia, oxidative stress, liver steatosis.
This paper reports the most northern record of Mesoplodon europaeus for southern hemisphere based on a specimen beaked whale that stranded Bitupitá Beach (02°53'94"S; 41°16'41"W), northeastern coast Brazil, 23 November 2001. Identification this individual was position two mandibular teeth in lower jaw. The were flattened laterally, embedded jaw at symphysis, and located posterior to middle Until recently, distribution species considered limited Atlantic Ocean, occurrence stranding events...
ContextLiver transplantation is one of the last viable resources for patients with end-stage liver disease. Many strategies are been used to improve number available organs and overcome waiting list delay. However, hepatic steatosis mainly concerns when consider due it importance as a risk factor primary dysfunction. Surgeons play an important role decide each organ will be accept or decline its righteous allocation.ObjectiveRetrospectively evaluate surgeon assessment degree confrontation...
The present study was conducted to investigate the global proteome of 8-day-old equine blastocysts. Follicular dynamics eight adult mares were monitored by ultrasonography and inseminated 24 h after detection a preovulatory follicle. Four expanded blastocysts recovered, pooled, subjected protein extraction mass spectrometry. Protein identification based on four database searches (PEAKS, Proteome Discoverer software, SearchGUI PepExplorer). Enrichment analysis performed using g:Profiler,...