A5014170144- Mercury impact and mitigation studies
- Reproductive Biology and Fertility
- Heavy Metal Exposure and Toxicity
- Anesthesia and Neurotoxicity Research
- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Tissue Engineering and Regenerative Medicine
- Chromosomal and Genetic Variations
- Zebrafish Biomedical Research Applications
- Genetic diversity and population structure
- Phytochemicals and Medicinal Plants
- Gut microbiota and health
- Sperm and Testicular Function
- Birth, Development, and Health
- Andrographolide Research and Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Milk Quality and Mastitis in Dairy Cows
- Toxic Organic Pollutants Impact
- Nerve injury and regeneration
- Pharmacological Effects of Medicinal Plants
- Reproductive Physiology in Livestock
- Clostridium difficile and Clostridium perfringens research
- Veterinary Pharmacology and Anesthesia
- Neonatal and fetal brain pathology
- Cancer Risks and Factors
Universidade de Fortaleza
2015-2025
University of Coimbra
2020-2023
The zebrafish (Danio rerio) has been proposed as a low-cost and simple alternative to the use of higher vertebrates in laboratory research on novel compounds with antinociceptive potential. In this study, we tested adult an behavioral model formalin-induced nociception. We evaluated nociceptive effect 0.1% formalin (3 or 5 μL; intramuscularly [i.m.]), applied into tail lips, locomotor activity, using parameter number times fish crossed lines between quadrants glass Petri dish during...
ABSTRACT Methylmercury (MeHg) is markedly toxic to humans. Our study explores whether MeHg and high‐fat diet (HFD) can impair the intestinal barrier with microbiota dysbiosis in mice. Weanling mice were fed HFD or standard for 40 days. In last 20 days of diets, received either (20 mg/L) drinking water. Proximal small intestine, cecum, hair samples collected. Villus length, crypt depth, villus/crypt mucin2 lysozyme‐positive cell counts, ZO‐1 occludin gene expression, functional permeability...
Zebrafish is an excellent model that can be utilized as adjunct to current rodent models for studies of eye diseases because the anatomy and ultrastructural characterization its cornea show much similarity with human cornea. Therefore, we developed a behavioral corneal nociception using adult zebrafish (Danio rerio). We analyzed nociceptive effect hypertonic saline (0.15–5.0 M sodium chloride [NaCl]) applied surface right or left cornea, on animals' gender locomotor activity through...
Worldwide environmental tragedies of anthropogenic origin causing massive release metals and other pollutants have been increasing considerably. These pollution outbreaks affect the ecosystems impact human health. Among those tragedies, recent large-scale disasters in Brazil strongly affected riverside populations, leading to high-risk exposure methylmercury (MeHg). MeHg is highly neurotoxic developing brain. This toxicant causes neural stem cell dysfunction neurodevelopmental abnormalities....
OPINION article Front. Neurosci., 03 November 2020 | https://doi.org/10.3389/fnins.2020.576543
Keywords: methylmercury, ApoE, epididymal white fat, metabolomics, dyslipidemia, oxidative stress, liver steatosis.
Anticancer therapy often leads to premature ovarian insufficiency (POI) and infertility due the extreme sensitivity of follicle reserve effects chemotherapy. Withanolides are known for their cytotoxic effect on cancer cells low cytotoxicity non-malignant or healthy cells. Therefore, this study aimed investigate
The aim of this study was to evaluate the caprine preantral follicles enclosed on vitrified/warmed ovarian cortex grafted nude BALB/mice during 1 month. from goats fragmented (3 × 3 0.5 mm) and divided into four groups: fresh control, vitrified transplant transplant. Follicular morphology, development density, fibrosis as well apoptosis, tissue revascularization were evaluated. It also observed a significant decrease in morphologically normal (primordial, transition, primary secondary) both...
The last few years have seen a significant increase in the number of large-scale sequencing projects generating whole genome databases. These sequence databases can be surveyed (genome survey) for tandem repeats as an alternative means to develop microsatellites monitoring and selecting natural populations cultivars Jatropha curcas. A total 100 were revealed from mining 368 genomic sequences available Kazusa DNA Research Institute database. Twenty microsatellite successfully amplified,...
Methylmercury (MeHg) is highly toxic to the human brain. Although much known about MeHg neurotoxic effects, less how chronic affects hippocampal amino acids and other neurochemical markers in adult mice. In this study, we evaluated effects on systemic lipids inflammation, oxidative stress, acid levels, neuroinflammation, behavior male Challenged mice received drinking water (2 mg/L) for 30 days. We assessed weight gain, total plasma cholesterol (TC), triglycerides (TG), endotoxin, TNF...
Methylmercury (MeHg) is a dangerous environmental contaminant with strong bioaccumulation in the food chain and neurotoxic properties. In nervous system, MeHg may cause neurodevelopment impairment potentially interfere immune response, compromising proper control of neuroinflammation aggravating neurodegeneration. Human populations are exposed to contamination MeHg, especially areas mining or industrial activity, raising public health concerns. Taking this into consideration, work aims...
Ovarian tissue transplantation methods using cooled and cryopreserved samples have been attractive options for fertility preservation in animal models humans. The aim of this study was to evaluate the impact previous exposure cooling, cryopreservation, VEGF on overall efficiency equine ovarian after heterotopic xenotransplantation mice. end points evaluated were follicular morphology development, stromal cell densities, angiogenesis (i.e. density new mature blood vessels), collagen types I...
Varias camadas celulares, morfologicamente distintas, formam a mucosa vaginal. Essas variam em espessura ao longo do ciclo estral, durante gestacao, anestro e lactacao de acordo com o estimulo hormonal qual sao submetidas. O objetivo presente trabalho foi comparar perfil citologico vaginal cabras da raca Saanen ciclicas gestantes. Foram utilizadas dez Saanen, adultas, criadas sistema intensivo pertencentes plantel setor ovinocaprinocultura Faculdade Veterinaria Universidade Estadual Ceara....