A5080956531- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Organ Transplantation Techniques and Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease and Transplantation
- Forensic Toxicology and Drug Analysis
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Anesthesia and Sedative Agents
- Heart Rate Variability and Autonomic Control
- Renal Transplantation Outcomes and Treatments
- Alzheimer's disease research and treatments
- Pain Mechanisms and Treatments
- Muscle metabolism and nutrition
- Pancreatic function and diabetes
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Congenital Anomalies and Fetal Surgery
- Advanced Glycation End Products research
- Coffee research and impacts
- Hormonal Regulation and Hypertension
- Extracellular vesicles in disease
- Nausea and vomiting management
University of Coimbra
2014-2024
University of Minho
2022
Centro de Computação Gráfica
2022
Association for Innovation and Biomedical Research on Light and Image
2007-2021
Universidade de São Paulo
2019
Universidade de Ribeirão Preto
2019
National Center for Toxicological Research
2002-2006
Hospital Universitario Puerta de Hierro Majadahonda
1990-2002
Centro de Neurociências e Biologia Celular
2001
Clinica Universidad de Navarra
1989
Abstract Background Diabetic cardiomyopathy (DCM) is defined as structural and functional changes in the myocardium due to metabolic cellular abnormalities induced by diabetes mellitus (DM). The impact of prediabetic conditions on cardiac tissue remains be elucidated. goal this study was elucidate whether dysfunction already present a state prediabetes, presence insulin resistance, unravel underlying mechanisms, rat model without obesity hypertension confounding factors. Methods Two groups...
Amphetamines exert their persistent addictive effects by activating brain's reward pathways, perhaps through the release of dopamine in nucleus accumbens (and/or other places). On hand, there is a relationship between and all behavioural aspects that involve motor activity it has been demonstrated exercise leads to an increase synthesis dopamine, stimulates neuroplasticity promotes feelings well-being. Moreover, drugs abuse activate overlapping neural systems. Thus, our aim was study...
Glucotoxicity and lipotoxicity are key features of type 2 diabetes mellitus, but their molecular nature during the early stages disease remains to be elucidated. We aimed characterize glucose lipid metabolism in insulin-target organs (liver, skeletal muscle, white adipose tissue) a rat model treated with high-sucrose (HSu) diet. Two groups 16-week-old male Wistar rats underwent 9-week protocol: HSu diet (n = 10)—received 35% sucrose drinking water; Control 12)—received vehicle (water). Body...
Methamphetamine (METH) is a powerful psychostimulant whose noxious effects depend largely on the pattern of abuse. METH‐induced glutamate release may overactivate N ‐methyl‐ d ‐aspartate and α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid receptors (NMDAR AMPAR, respectively) causing excitotoxicity. In brain, these are also known for their essential role in mediating memory consolidation. Therefore, we assessed glial fibrillary acidic protein (GFAP) expression as marker astrogliosis...
Tramadol and tapentadol, two structurally related synthetic opioid analgesics, are widely prescribed due to the enhanced therapeutic profiles resulting from synergistic combination between μ-opioid receptor (MOR) activation monoamine reuptake inhibition. However, number of adverse reactions has been growing along with their increasing use misuse. The potential toxicological mechanisms for these drugs not completely understood, especially owing its shorter market history. Therefore, in...
Abstract: Type 2 diabetes mellitus (T2DM) is a major risk factor for developing cardiovascular disease and represents serious public health problem, with high rates of mortality morbidity worldwide. T2DM etiology complex multifactorial associated several complications, including those at myocardium level. Diabetic cardiomyopathy (DCM) viewed as specific defined structural functional changes in the due to metabolic cellular abnormalities induced by diabetes. has long been classified an...
Convincing evidence indicates that advanced glycation end-products and danger-associated protein S100B play a role in Parkinson's disease (PD). These agents operate through the receptor for (RAGE), which displays distinct isoforms playing protective/deleterious effects. However, nature of RAGE variants has been overlooked PD studies. Hence, we attempted to characterize regulation early stages striatal pathology. A neurotoxin-based rodent model was used this study, administration...
Tramadol and tapentadol, synthetic opioids commonly prescribed for moderate-to-severe pain, have a unique pharmacology that optimizes their analgesia safety. However, they are not devoid of risks, presenting addictive, abuse, dependence potential. While tramadol-reinforcing properties been documented by various studies with human animal models, including conditioned place preference (CPP) assays, no similar performed tapentadol. In the present study, we CPP assays intraperitoneally...
Proinflammatory cytokines powerfully induce the rate-limiting enzyme indoleamine 2, 3-dioxygenase-1 (IDO-1) in dendritic cells (DCs) and monocytes, it converts tryptophan (Trp) into L-kynurenine (KYN), along kynurenine pathway (KP). This mechanism represents a crucial innate immunity regulator that can modulate T cells. work explores role of IDO1 lymphocyte proliferation within specific pro-inflammatory milieu.
Methamphetamine (METH), leading to striatal dopamine (DA) nerve terminal toxicity in mammals, is also thought induce apoptosis of neurons rodents. We investigated the acute effects induced by multiple injections METH (4 x 5 mg/kg, i.p.) at 2-h intervals or a single injection (20 on dopaminergic markers, including DA levels, turnover, and tyrosine hydroxylase (TH) immunoreactivity rat caudate-putamen (CPu). further whether both treatment paradigms would change Bax activate caspase-3...