A5069182669- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Adenosine and Purinergic Signaling
- Olfactory and Sensory Function Studies
- Public Health in Brazil
- Nerve injury and regeneration
- Neurological disorders and treatments
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Pain Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Vagus Nerve Stimulation Research
- Sesquiterpenes and Asteraceae Studies
- Alzheimer's disease research and treatments
- Restless Legs Syndrome Research
- Child Nutrition and Water Access
- Brazilian Legal Issues
- Medical Malpractice and Liability Issues
- Pancreatic function and diabetes
- Phytochemistry Medicinal Plant Applications
- Inflammasome and immune disorders
- Health, Nursing, Elderly Care
- Respiratory Support and Mechanisms
- Linguistics and Education Research
- Education during COVID-19 pandemic
Universidade Federal de Santa Catarina
2014-2025
University of Coimbra
2015-2022
Polytechnic Institute of Castelo Branco
2016
Universidade Federal de Juiz de Fora
2008
Objetivo: Analisar a vulnerabilidade social de pacientes internados em uma unidade reabilitação hospitalar e seu acesso medicamentos pelo Sistema Único Saúde (SUS) do Distrito Federal (DF). Métodos: Estudo observacional, descritivo, transversal, utilizando dados retrospectivos 99 entre janeiro dezembro 2022. Foram analisadas variáveis sociodemográficas, clínicas presença prescritos nas listas essenciais da Organização Mundial (OMS), Relação Nacional Medicamentos Essenciais (RENAME) Lista...
Purpose: Spinal cord injury (SCI) can result in the partial or total loss of motor, sensory, and autonomic functions, along with various psycho-emotional complications, impacting both individuals their families. The objective this study was to examine sociodemographic clinical profile patients SCI at hospital discharge from a rehabilitation long-term care unit. Methods: This an observational, descriptive, retrospective cross-sectional design. Data were collected hospitalized between January...
Affective disorders and memory impairments precede the classical motor symptoms seen in Parkinson's disease (PD) currently approved antiparkinsonian agents do not alleviate non-motor as well underlying dopaminergic neuron degeneration. On other hand, there is increasing evidence that inflammation plays a key role pathophysiology of PD anti-inflammatory actions statins are related to their neuroprotective properties against different insults CNS. The present data indicates oral treatment with...
Abstract Extracellular ATP can be a danger signal, but its role in striatal circuits afflicted Parkinson’s disease (PD) is unclear and was now investigated. particularly released at high stimulation intensities from purified nerve terminals of mice, which were endowed with different ATP-P2 receptors (P2R), although P2R antagonists did not alter corticostriatal transmission or plasticity. Instead, extracellularly catabolized into adenosine through CD73 to activate A 2A (A R) modulating...
The chemical composition of the essential oil from air-dried leaves Eremanthus erythropappus was studied. main compounds were beta-pinene (23.24%), beta-caryophyllene (22.92%), beta-myrcene (10.03%) and germacrene D (9.40%). had an LD50 2.90 g kg(-1) in mice. Doses 200 400 mg inhibited 10.69% 27.06% acetic-acid-induced writhing mice, respectively. In formalin-induced nociception test first phase paw licking by 29.13% (400 kg(-1)) second 32.74% (200 37.55% kg(-1)). hot-plate doses...
Neopterin is found at increased levels in biological fluids from individuals with inflammatory disorders. The role of this pteridine remains undefined; however, due to its capacity increase hemeoxygenase-1 content, it has been proposed as a protective agent during cellular stress. Therefore, we investigated the effects neopterin on motor, emotional and memory functions. To address question, (0.4 and/or 4pmol) was injected intracerebroventricularly before or after training sessions step-down...
Abdominal pain is a frequent symptom of peritoneal cavity irritation, but little known about the role receptors for irritant substances, transient receptor potential vanilloid 1 (TRPV1) and ankyrin (TRPA1), in this painful condition. Thus, we investigated abdominal nociception caused by stimulation with TRPV1 (capsaicin) TRPA1 (allyl isothiocyanate, AITC) agonists their mechanisms rats. The intraperitoneal (i.p.) injection either capsaicin or AITC (0.03–10 mg/kg) induced short-term (up to 20...
O presente trabalho investigou as propriedades antinociceptiva, antiinflamatória e antiulcerogênica do extrato etanólico dos galhos de E. erythropappus. Foram realizados os testes contorções abdominais induzidas por ácido acético; tempo da lambida pata induzida formalina; placa quente; edema induzido carragenina; lesões ulcerativas indometacina etanol. As doses 50, 100 200 mg/kg inibiram em 43,07%, 69,34% 70,07%, respectivamente. foi reduzido ambas fases nas testadas, enquanto o latência...
Tardive dyskinesia (TD) is a serious motor side effect that may appear after long-term treatment with neuroleptics and mostly mediated by dopamine D2 receptors (D2Rs). Striatal D2R functioning be finely regulated either adenosine A2A receptor (A2AR) or angiotensin type 1 (AT1R) through putative heteromers. Here, we examined whether A2AR AT1R oligomerize in the striatum to synergistically modulate dopaminergic transmission. First, using bioluminescence resonance energy transfer, demonstrated...