A5034593589- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Genetics, Aging, and Longevity in Model Organisms
- Neuroscience and Neuropharmacology Research
- Mercury impact and mitigation studies
- Aluminum toxicity and tolerance in plants and animals
- Alzheimer's disease research and treatments
- Melanoma and MAPK Pathways
- Computational Drug Discovery Methods
- Glycosylation and Glycoproteins Research
- Selenium in Biological Systems
- Medicinal Plants and Neuroprotection
- Agricultural pest management studies
- Coenzyme Q10 studies and effects
- Histone Deacetylase Inhibitors Research
- Invertebrate Immune Response Mechanisms
- Indoor Air Quality and Microbial Exposure
- Luminescence and Fluorescent Materials
- Gut microbiota and health
- bioluminescence and chemiluminescence research
- Neurogenesis and neuroplasticity mechanisms
- Epilepsy research and treatment
- Tryptophan and brain disorders
- Olfactory and Sensory Function Studies
- Protein Kinase Regulation and GTPase Signaling
Imperial College London
2023-2025
Medical Research Council
2024
Albert Einstein College of Medicine
2014-2021
Universidade Federal de Santa Catarina
2011-2019
The Bronx Defenders
2016
Brazilian National Association of Graduate Programs in Communication
2016
In-Q-Tel
2016
State University of Norte Fluminense
2012
Manganese (Mn) is an essential metal for development and metabolism. However, exposures to high Mn levels may be toxic, especially the central nervous system (CNS). Neurotoxicity commonly due occupational or environmental leading accumulation in basal ganglia a Parkinsonian-like disorder. Younger individuals are more susceptible toxicity. Moreover, early exposure represent risk factor of neurodegenerative diseases later life. The present study was undertaken investigate developmental...
Many health claims have been made about the medicinal benefits of drinking green tea, including neuroprotection. This study mainly focuses on Epigallocatechin 3-gallate (EGCG), a potent antioxidant, which is abundantly found in tea. Cadmium [Cd(2+)] toxic pollutant that leads to neurotoxicity both animals and humans. Although entrance Cd(2+) adult central nervous system limited, developmental has evidenced as result blood-brain barrier (BBB) immaturity. Moreover, high levels are known impair...
Abstract Manganese (Mn) is one of the most abundant metals on earth. It required for normal cellular activities, but overexposure leads to toxicity. Neurons are more susceptible Mn-induced toxicity than other cells, and accumulation Mn in brain results Manganism that presents with Parkinson's disease (PD)-like symptoms. In last decade, a number transporters have been identified, which improves our understanding transport out cells. However, mechanism neurotoxicity only partially uncovered,...
Abstract G protein-coupled receptors (GPCRs) mediate responses to various extracellular and intracellular cues. However, the large number of GPCR genes their substantial functional redundancy make it challenging systematically dissect functions in vivo. Here, we employ a CRISPR/Cas9-based approach, disrupting 1654 GPCR-encoding 284 strains mutating 152 neuropeptide-encoding 38 C. elegans . These two mutant libraries enable effective deorphanization chemoreceptors, characterization for...
Abstract Diet is believed to be an important mediator of oncogenesis and response anti-cancer therapies, although no evidence-based dietary guidelines exist for patients with cancer. Limiting protein intake can suppress tumor growth by both inducing nutrient stress enhancing anti-tumor immunity. However, little known about the impact reducing on efficacy chemotherapy, most widely used treatment. Here, we present evidence that in mice 50% stops established tumors, parallel a DNA damage....
Organic selenium and tellurium compounds are known for their broad-spectrum effects in a variety of experimental disease models. However, these commonly display high toxicity the molecular mechanisms underlying deleterious have yet to be elucidated. Thus, need an animal model that is inexpensive, amenable high-throughput analyses, feasible studies highly desirable improve organochalcogen pharmacological toxicological characterization. Herein, we use Caenorhabdtis elegans (C. elegans) as...
Abstract Background Tuberculosis, caused by Mycobacterium tuberculosis or bovis, remains one of the leading infectious diseases worldwide. The ability mycobacteria to rapidly grow in host macrophages is a factor contributing enhanced virulence bacteria and disease progression. Bactericidal functions phagocytes are strictly dependent on activation status these cells, regulated infecting agent cytokines. Pathogenic can survive hostile environment phagosome through interference with...
Here we show that a systemic injection of the histone deacetylase inhibitor (HDACi) sodium butyrate (NaB) immediately after training in step-down inhibitory avoidance task produced an enhancement memory consolidation persisted across consecutive retention tests during 14 days aged rats, while it did not significantly affect young adults. Control and adult rats showed comparable basal levels retention. Our results suggest HDACis can display memory-enhancing effects specific for animals, even...
Understanding how the microbiota produces regulatory metabolites is of significance for cancer and therapy. Using a host-microbe-drug-nutrient 4-way screening approach, we evaluated role nutrition at molecular level in context 5-fluorouracil toxicity. Notably, our screens identified metabolite 2-methylisocitrate which was found to be produced enriched human tumor-associated microbiota. exhibits anti-proliferative properties across genetically- tissue-diverse cell lines, 3D spheroids, an vivo...
The influence of routine guarana (Paullinia cupana) consumption on apparent tolerance to mercury intoxication has been proposed. present study investigated this hypothesis in Caenorhabditis elegans, a suitable experimental model for studies toxicology. Wild type (WT) and skn-1 (ok2315) worm strains were pretreated with ethanolic extract (GEE) from larvae 1 (L1) L4 stage then exposed 6 hours methylmercury (MeHg). analyses included evaluation GEE's effects lethality, developmental delay,...
Methylmercury (MeHg) is an environmental pollutant that affects primarily the central nervous system (CNS), causing neurological alterations. An early symptom of MeHg poisoning loss body weight and appetite. Moreover, CNS has important role in controlling energy homeostasis. It known hypothalamus nutrient hormonal signals converge to orchestrate control food intake. In this study, we investigated if able induce changes expression key hypothalamic neuropeptides regulate Thus, neuronal mouse...
The excitotoxicity induced by excessive activation of the glutamatergic neurotransmission pathway is involved in several neuropathologies. In this sense, molecules that prevent release glutamate or its receptors can be useful preventing neuronal cell death observed these diseases. Lectins are proteins capable reversible binding to carbohydrates glycoconjugates, and some have been used study purification receptors. ConBr a mannose/glucose-binding lectin purified from Canavalia brasiliensis...