A5057449292- Nutrition, Genetics, and Disease
- Diet and metabolism studies
- Gut microbiota and health
- Skin and Cellular Biology Research
- Microtubule and mitosis dynamics
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Inflammatory mediators and NSAID effects
- Inflammatory Bowel Disease
- Web and Library Services
- Immunodeficiency and Autoimmune Disorders
- Social Media in Health Education
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Nuclear Structure and Function
- Metabolomics and Mass Spectrometry Studies
- Microscopic Colitis
- Mobile Learning in Education
- Cancer Diagnosis and Treatment
- Inflammation biomarkers and pathways
- Zebrafish Biomedical Research Applications
- IL-33, ST2, and ILC Pathways
Stony Brook Medicine
2018-2025
Stony Brook University
2019-2024
Stony Brook School
2019-2024
University of Toronto
2014-2015
Abstract Diet is believed to be an important mediator of oncogenesis and response anti-cancer therapies, although no evidence-based dietary guidelines exist for patients with cancer. Limiting protein intake can suppress tumor growth by both inducing nutrient stress enhancing anti-tumor immunity. However, little known about the impact reducing on efficacy chemotherapy, most widely used treatment. Here, we present evidence that in mice 50% stops established tumors, parallel a DNA damage....
Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the second leading cause of cancer‐related deaths in United States by 2020, due part innate resistance widely used chemotherapeutic agents and limited knowledge about key molecular factors that drive tumor aggression. We previously reported a novel negative prognostic biomarker, keratin 17 (K17), whose overexpression cancer results shortened patient survival. In this study, we aimed determine predictive value K17 explore...
Abstract Bacteria are believed to play an important role in intestinal tumorigenesis and contribute both gut luminal circulating metabolites. Celecoxib, a selective cyclooxygenase-2 inhibitor, alters bacteria metabolites association with suppressing the development of polyps mice. The current study sought evaluate whether celecoxib exerts its chemopreventive effects, part, through metabolomic alterations. Using ApcMin/+ mice, we demonstrated that treatment broad-spectrum antibiotics (ABx)...
Abstract Introduction. Although patients with pancreatic ductal adenocarcinoma (PDAC) have one of the lowest survival all carcinomas, there is considerable variation in and disease progression, even when accounting for factors such as age pathologic stage. Our group identified keratin 17 (K17) a negative prognostic predictive biomarker PDAC. Patients high K17 expression their tumors shorter overall well decreased response to chemotherapeutic agents, including gemcitabine. has also emerged an...
Cancers evolve in a dynamic ecosystem. Thus, characterizing cancer's ecological dynamics is crucial to understanding cancer evolution and can lead discovering novel biomarkers predict disease progression. Ductal carcinoma situ (DCIS) an early-stage breast characterized by abnormal epithelial cell growth confined within the milk ducts. In this study, we show that habitat analysis of hypoxia acidosis significantly improve prediction DCIS upstaging. First, developed eco-evolutionary designed...
Abstract Breast cancer risk increases significantly in women who maintain higher radiologically dense breast tissue as they age. However, the mechanisms that underlie this association remain poorly understood, especially postmenopausal women. A predominant contributor to breasts and differences between is relative amount of fibrillar collagens. Experimental models suggest changes collagen properties such fiber alignment stiffness promote local stromal fibrosis, which we hypothesize may...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the second leading cause of cancer-related deaths in United States by 2020, due part innate resistance widely used chemotherapeutic agents and limited knowledge about key molecular factors that drive tumor aggression. We previously reported a novel negative prognostic biomarker, keratin 17 (K17), whose overexpression cancer results shortened patient survival. In this study, we aimed determine predictive value K17 explore...
Introduction/rationale: Current anti-diabetic drug treatments have a variety of adverse side effects. Identifying functional foods with properties may be the key to preventing and managing T2DM while minimizing Studies found that Pck-1 gene is often down-regulated by drugs, as its enzyme responsible for catalyzing rate-limiting step gluconeogenesis. In our study, we screened can down-regulate expression gene. The newly emerged zebrafish (Danio rerio) aptly suited in vivo nutrigenomic...
<div>Abstract<p>Bacteria are believed to play an important role in intestinal tumorigenesis and contribute both gut luminal circulating metabolites. Celecoxib, a selective cyclooxygenase-2 inhibitor, alters bacteria metabolites association with suppressing the development of polyps mice. The current study sought evaluate whether celecoxib exerts its chemopreventive effects, part, through metabolomic alterations. Using <i>Apc<sup>Min/+</sup></i> mice, we...
Supplementary Figure from Microbes Contribute to Chemopreventive Efficacy, Intestinal Tumorigenesis, and the Metabolome
Supplementary Figure from Microbes Contribute to Chemopreventive Efficacy, Intestinal Tumorigenesis, and the Metabolome
<div>Abstract<p>Bacteria are believed to play an important role in intestinal tumorigenesis and contribute both gut luminal circulating metabolites. Celecoxib, a selective cyclooxygenase-2 inhibitor, alters bacteria metabolites association with suppressing the development of polyps mice. The current study sought evaluate whether celecoxib exerts its chemopreventive effects, part, through metabolomic alterations. Using <i>Apc<sup>Min/+</sup></i> mice, we...