A5037557415- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Parkinson's Disease Mechanisms and Treatments
- Cardiac Arrest and Resuscitation
- Stroke Rehabilitation and Recovery
- S100 Proteins and Annexins
- Neurological disorders and treatments
- Acute Ischemic Stroke Management
- Alzheimer's disease research and treatments
- Glycogen Storage Diseases and Myoclonus
- Inflammatory Myopathies and Dermatomyositis
- Migraine and Headache Studies
- Sepsis Diagnosis and Treatment
- Cholinesterase and Neurodegenerative Diseases
- HIV Research and Treatment
- Meningioma and schwannoma management
- Cerebrovascular and genetic disorders
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Caveolin-1 and cellular processes
- Neurological diseases and metabolism
- Trauma and Emergency Care Studies
Universidade Federal de Santa Catarina
2015-2024
Brazilian Institute of Neuropsychology and Behaviour
2016-2023
Polydoro Ernani de São Thiago University Hospital
2012-2022
Centro de Estudos e Pesquisa em Saúde Coletiva
2011-2021
Universidade Federal do Rio de Janeiro
2021
Governador Celso Ramos Hospital
2011-2019
Charité - Universitätsmedizin Berlin
2015
Colciencias
2012
Fundação de Amparo à Pesquisa do Estado da Bahia
2006
Traumatic brain injury (TBI) is a major cause of death and disability impairs health-related quality life (HRQOL). Psychiatric disorders have been recognized as components TBI morbidity, yet few studies addressed the relationship between these outcomes. Sample size, selection bias, retrospective design, are methodological limitations for TBI-related psychiatric studies. For this study, 33 patients with severe were evaluated prospectively regarding demographic, clinical, radiological,...
<b><i>Background:</i></b> Cytokines have been shown to be involved in traumatic brain injury (TBI). We investigated the independent association between serum levels of IL-10 and TNF-α hospital mortality patients with severe TBI. <b><i>Methods:</i></b> Serum were determined after a median period (interquartile range (IQ) 25–75) 10 h (IQ 5–18) TBI 93 consecutive randomly selected mild (n = 18) moderate 16) In TBI, additional blood samples...
The association between biomarkers of oxidative stress and the prognosis patients with traumatic brain injury (TBI) remains inconclusive.The objective was to investigate plasma levels lipid peroxidation (thiobarbituric acid reactive species [TBARS]) protein oxidation (carbonyl) hospital mortality severe TBI.Plasma TBARS carbonyl were determined in 79 consecutive TBI (Glasgow Coma Scale [GCS] ≤8) at a median 12 hours (interquartile range [IQ] 25-75, 6.5-19.0), 30 (IQ 24.7-37.0), 70 55.0-78.5)...
To investigate prospectively the independent predictors of a minimum clinically important change (MCIC) in quality life (QOL) after anterior temporal lobectomy (ATL) for drug-resistant mesial lobe epilepsy related to hippocampal sclerosis (MTLE-HS) Brazilian patients.Multiple binary logistic regression analysis was performed identify clinical, demographic, radiologic, and electrophysiologic variables independently associated with MCIC Quality Life Epilepsy-31 Inventory (QOLIE-31) overall...
There is increasing evidence that hypercholesterolemia during midlife may represent a predictor of subsequent mild cognitive impairments and dementia decades later. However, the exact mechanism underlying this phenomenon remains unknown since plasmat
Objective: To evaluate the validity and utility of Hamilton Rating Scale for Depression (HAM-D), Beck Inventory (BDI), Hospital Anxiety (HADS) as screening tools depression after severe traumatic brain injury (TBI). Methods: Forty-six consecutive survivors TBI were evaluated at a median 15 months injury. Receiver operating characteristic (ROC) analysis was performed using HAM-D, BDI, HADS predictors, Structured Clinical Interview DSM-IV Axis I Disorders (SCID-I) gold standard. Results: The...
To evaluate predictors of non-return to work (nRTW) among social, demographic, clinical, and psychiatric variables after severe traumatic brain injury (TBI) in a cohort Brazilian patients.Prospective study. Forty-three community-dwelling individuals treated at Level I trauma center the time TBI were evaluated 18 months trauma. Measures included DSM-IV-TR criteria for personality changes Structured Clinical Interview DSM-IV Axis Disorders (SCID-I) assess diagnosis. Hospitalization Glasgow...
Abstract Glucocorticoids (GC) released during stress response exert feedforward effects in the whole brain, but particularly limbic circuits that modulates cognition, emotion and behavior. GC are most commonly prescribed anti-inflammatory immunosuppressant medication worldwide pharmacological treatment has been paralleled by high incidence of acute chronic neuropsychiatric side effects, which reinforces brain sensitivity for GC. Synapses can be bi-directionally modifiable via potentiation...
Objectives To identify variables independently associated with a meaningful improvement in QOL long after surgical treatment of drug-resistant MTLE-HS patients. Material & Methods We prospectively evaluated 72 consecutive surgically treated patients and analyzed pre post-surgical by the Quality Life Epilepsy-31 (QOLIE-31) overall score, its domain scores determined at follow-up 36 to 131 months (mean 93 months) surgery. Results The mean QOLIE-31 score subdomain improved significantly surgery...
Objective: Clinical and experimental evidences indicate that intrauterine inflammation during pregnancy is associated to brain damage. The objective of this study determine the effects lipopolysaccharide in temperature, cytokine production sickness behavior pregnant dams.