A5033159462- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Attention Deficit Hyperactivity Disorder
- Sleep and Wakefulness Research
- Adenosine and Purinergic Signaling
- Alzheimer's disease research and treatments
- Epilepsy research and treatment
- Bipolar Disorder and Treatment
- Pain Mechanisms and Treatments
- Neuroendocrine regulation and behavior
- Neuroscience of respiration and sleep
- Fatty Acid Research and Health
- Functional Brain Connectivity Studies
- Diet, Metabolism, and Disease
- Biochemical effects in animals
- Anesthesia and Neurotoxicity Research
- Neurological diseases and metabolism
- Prion Diseases and Protein Misfolding
- Adipose Tissue and Metabolism
- Cholesterol and Lipid Metabolism
- Nuclear Receptors and Signaling
- Sepsis Diagnosis and Treatment
Universidade Federal da Integração Latino-Americana
2021-2022
D’Or Institute for Research and Education
2012-2022
Fundação Oswaldo Cruz
2021-2022
University for International Integration of the Afro-Brazilian Lusophony
2021
Max Planck Institute of Psychiatry
2009-2017
Universidade Federal de Santa Catarina
2005-2016
Max Planck Society
2011-2012
Global Neuroscience Initiative Foundation
2012
Colciencias
2010
Allosteric modulation of G-protein–coupled receptors represents a key goal current pharmacology. In particular, endogenous allosteric modulators might represent important targets interventions aimed at maximizing therapeutic efficacy and reducing side effects drugs. Here we show that the anti-inflammatory lipid lipoxin A 4 is an enhancer CB 1 cannabinoid receptor. Lipoxin was detected in brain tissues, did not compete for orthosteric binding site receptor (vs. 3 H-SR141716A), alter...
This meta-analysis paper describes the analysis of observational clinical studies on treatment refractory epilepsy with cannabidiol (CBD)-based products. Beyond attempting to establish safety and efficacy such products, we also investigated if there is enough evidence assume any difference in between CBD-rich extracts compared purified CBD The systematic search took place February/2017 updated December/2017 using keywords “epilepsy” or “Dravet” “Lennox-Gastaut” “CDKL5” combined "Cannabis",...
The spontaneously hypertensive rat (SHR) is generally considered to be a suitable genetic model for the study of attention deficit hyperactivity disorder (ADHD), since it displays hyperactivity, impulsivity, poorly sustained attention, and deficits in learning memory processes. Converging evidence suggests primary role disturbance dopaminergic neurotransmission ADHD patients SHR, addition, some studies have also demonstrated alterations adenosinergic SHR. In present study, adult female...
The strain of spontaneously hypertensive rats (SHR) is considered a genetic model for the study attention-deficit hyperactivity disorder (ADHD), as it displays hyperactivity, impulsivity and poorly sustained attention. Recently, we have shown involvement adenosinergic neuromodulation in SHR's short-term long-term memory impairments. In this study, investigated performance male female SHR modified version object-recognition task (using objects with different structural complexity) compared...
The interaction between genes and environment seems to be relevant for the development of Attention Deficit/Hyperactivity Disorder (ADHD), one most prevalent childhood psychiatric diseases. occurrence ADHD is typically associated with poor academic performance, probably reflecting learning difficulties and/or cognitive impulsiveness. inbred Spontaneously Hypertensive Rats (SHR) strain has often been considered as an animal model ADHD, since they 'naturally' display main symptomatology....
There is increasing evidence that hypercholesterolemia during midlife may represent a predictor of subsequent mild cognitive impairments and dementia decades later. However, the exact mechanism underlying this phenomenon remains unknown since plasmat
Abstract Background Cannabinoid-based therapy has been shown to be promising and is emerging as crucial for the treatment of cognitive deficits, mental illnesses, many diseases considered incurable. There a need find an appropriate Alzheimer’s disease, cannabinoid-based appears feasible possibility. Case presentation This report addresses beneficial effect cannabinoids in microdoses on improving memory brain functions patient with mild-stage disease. The 75-year-old white man presenting main...