A5103040712- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Sports Performance and Training
- Cannabis and Cannabinoid Research
- Cardiovascular and exercise physiology
- Muscle activation and electromyography studies
- Tryptophan and brain disorders
- Autophagy in Disease and Therapy
- Metabolism and Genetic Disorders
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Birth, Development, and Health
- Endoplasmic Reticulum Stress and Disease
- Treatment of Major Depression
- Rheumatoid Arthritis Research and Therapies
- Pharmacological Effects and Toxicity Studies
- Ubiquitin and proteasome pathways
- Epilepsy research and treatment
- Fish biology, ecology, and behavior
- Photoreceptor and optogenetics research
- Adolescent and Pediatric Healthcare
- Olfactory and Sensory Function Studies
- Reproductive Biology and Fertility
Max Planck Institute of Psychiatry
2011-2024
University Hospital Bonn
2022-2024
Paracelsus Medical University
2020-2024
Technical University of Munich
2024
University of Konstanz
2018-2023
University of Bonn
2020
Max Planck Society
2010-2017
Charles University
1961
Background FK506 binding protein 51 (FKBP51) is an Hsp90 co-chaperone and regulator of the glucocorticoid receptor, consequently stress physiology. Clinical studies suggest a genetic link between FKBP51 antidepressant response in mood disorders; however, underlying mechanisms remain elusive. The objective this study was to elucidate role actions antidepressants, with particular focus on pathways autophagy. Methods Findings Established cell lines, primary neural cells, human blood cells...
The localization, number, and function of postsynaptic AMPA-type glutamate receptors (AMPARs) are crucial for synaptic plasticity, a cellular correlate learning memory. Hippo pathway member WWC1 is an important component AMPAR-containing protein complexes. However, the availability constrained by its interaction with kinases LATS1 LATS2 (LATS1/2). Here, we explored biochemical regulation this found that it pharmacologically targetable in vivo. In primary hippocampal neurons, phosphorylation...
There exists substantial evidence that some forms of explicit learning in mammals require long-term potentiation (LTP) at hippocampal CA3-CA1 synapses. While CA1 LTP has been well characterized the monosynaptic level, it still remains unclear how afferent systems to hippocampus can initiate formation this neuroplastic phenomenon. Using voltage-sensitive dye imaging (VSDI) a mouse brain slice preparation, we show evoked entorhinal cortical (EC) theta-frequency input dentate gyrus highly...
Neuropeptide S (NPS) increasingly emerges as a potential novel treatment option for anxiety diseases like panic and posttraumatic stress disorder. However, the neural underpinnings of its anxiolytic action are still not clearly understood. Recently, we reported that neurons ventral hippocampus (VH) take up intranasally administered fluorophore-conjugated NPS and, moreover, application to mouse brain slices affects neurotransmission plasticity at hippocampal CA3-CA1 synapses. Although these...
βB2-crystallin (gene symbol: Crybb2/CRYBB2) was first described as a structural protein of the ocular lens. This gene, however, is also expressed in several regions mammalian brain, although its function this organ remains entirely unknown. To unravel some aspects we combined behavioral, neuroanatomical, and physiological analyses novel Crybb2 mouse mutant, O377. Behavioral tests with male O377 mutants revealed altered sensorimotor gating, suggesting modified neuronal functions. Since these...
During a continuously increasing exercise workload (WL) point will be reached at which arterial lactate accumulates rapidly. This so-called threshold (LT) is associated with the maximal steady state (MLSSW), highest WL, concentration [LA] does not change. However, physiological range in LT and MLSSW occur has been demonstrated directly. We used minor WL variations to assess kinetics 278 treadmill 148 bicycle ergometer tests. At certain workload, minimal further increment of running speed...
Antidepressants (ADs) are used as first-line treatment for most stress-related psychiatric disorders. The alterations in brain circuit dynamics that can arise from stress exposure and underlie therapeutic actions of ADs remain, however, poorly understood. Here, enabled by a recently developed voltage-sensitive dye imaging (VSDI) assay mouse slices, we examined the impact chronic concentration-dependent effects eight clinically (belonging to different chemical/functional classes) on evoked...
In cycling, propulsion is generated by the muscles of lower limbs and hips. After first reports pedal/crank force measurements in late 1960s, it has been assumed that highly trained athletes have better power transfer to pedals than recreational cyclists. However, motor patterns indicating higher levels performance are unknown. To compare leg muscle activation between (3.5-4.2 W/kgbw) (4.3-5.1 we applied electromyography, lactate, bi-pedal/crank during a maximal test, an individual lactate...
The lactate threshold (LT) and the strongly related maximal steady state workload (MLSS W ) are critical for physical endurance capacity therefore of major interest in numerous sports. However, their relevance to individual swimming performance is not well understood. We used a custom-made visual light pacer real-time speed modulation during front crawl determine LT MLSS single-exercise test. When approaching LT, we found that minute variations had considerable effects on blood concentration...
Anxiety disorders like post-traumatic stress disorder or obsessive-compulsive are frequently diagnosed and often occur in combination with other mental illnesses. Exposure-based therapies along medication widely used as treatment for most of these brain based diseases. The benzodiazepines usually considered second-line due their impact on amnestic functions. In contrast, substances targeting the endocannabinoid system were found to be effective anxiolytics without disadvantages memory...
Voltage-sensitive dye imaging (VSDI) is a neurophysiological technique which allows to measure the spatiotemporal dynamics of neuronal network activity with micrometer spatial and millisecond temporal resolution. This method uses specific fluorescent dyes insert into cytoplasmic membranes report changes in membrane potential as fluorescence intensity. We established VSDI assays murine brain slice preparations permit investigation important aspects hippocampal amygdalar physiology. First...
Psychiatric disorders are largely characterized by alterations in behaviour and emotions, but the underlying changes neural signal processing poorly understood. To engage circuit-centered approaches thereby uncover modifications neuronal network activity, we established a high-speed voltage-sensitive-dye imaging assay allowing investigation of several aspects polysynaptic activity flow within hippocampus vitro. We could show that theta-frequency stimulation perforant path reliably generates...