A5083883065- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Metabolism and Genetic Disorders
- Glycogen Storage Diseases and Myoclonus
- Ion channel regulation and function
- Genetics and Neurodevelopmental Disorders
- Psychosomatic Disorders and Their Treatments
- Cardiac electrophysiology and arrhythmias
- Diet and metabolism studies
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- Muscle activation and electromyography studies
- Neurology and Historical Studies
- Genomics and Rare Diseases
- Neonatal and fetal brain pathology
- Neural dynamics and brain function
- Infectious Encephalopathies and Encephalitis
- Drug Transport and Resistance Mechanisms
- Pharmaceutical studies and practices
- Neurobiology of Language and Bilingualism
- Sleep and Wakefulness Research
- Mitochondrial Function and Pathology
Filadelfia
2015-2024
Universidade Federal de Santa Catarina
2015-2024
Vilnius University
2021-2024
Polydoro Ernani de São Thiago University Hospital
2017-2022
National Institute of Neurological Disorders and Stroke
2020
University Hospital of Lausanne
2020
Aarhus University Hospital
2018-2020
The University of Texas Health Science Center at Houston
2020
FORCE Technology (Denmark)
2020
Carol Davila University of Medicine and Pharmacy
2020
Comparing the determination of language dominance using fMRI with results Wada test in 100 patients different localization-related epilepsies, authors found 91% concordance between both tests. The overall rate false categorization by was 9%, ranging from 3% left-sided temporal lobe epilepsy (TLE) to 25% extratemporal epilepsy. Language might reduce necessity for lateralization, especially TLE.
Photosensitivity is the most common mode of seizure precipitation. It age-related, more frequent in females, and often found generalised epilepsies. Little known about its relation to individual epileptic syndromes. This study on 1062 patients who had 4007 split screen video EEG investigations revealed that epilepsy even close than generally believed. Versive seizures with visual hallucinations was only focal type related photosensitivity. Of syndromes epilepsy, childhood absence juvenile...
<h3>Objective</h3> To determine the accuracy of automated detection generalized tonic-clonic seizures (GTCS) using a wearable surface EMG device. <h3>Methods</h3> We prospectively tested technical performance and diagnostic real-time seizure The algorithm cutoff values were prespecified. A total 71 patients, referred to long-term video-EEG monitoring, on suspicion GTCS, recruited in 3 centers. Seizure was fully automated. reference standard evaluation recordings by trained experts, who...
To characterize the spatial relationship between activations related to language-induced seizure activity, language processing, and motor control in patients with reading epilepsy.We recorded simultaneously monitored several physiological parameters [voice-recording, electromyography (EMG), electrocardiography (ECG), electroencephalography (EEG)] during blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) nine epilepsy. Individually tailored paradigms were used...
Summary Purpose Neurexins are neuronal adhesion molecules located in the presynaptic terminal, where they interact with postsynaptic neuroligins to form a transsynaptic complex required for efficient neurotransmission brain. Recently, deletions and point mutations of neurexin 1 ( NRXN1 ) gene have been associated broad spectrum neuropsychiatric disorders. This study aimed investigate if also increase risk idiopathic generalized epilepsies IGE s). Methods We screened involving 1,569 patients...
Summary Purpose: Previous studies have suggested that cognitive tasks modulate (provoke or inhibit) the epileptiform electroencephalography (EEG) discharges (EDs) in patients with juvenile myoclonic epilepsy (JME). Their inhibitory effect was found to be especially frequent (64–90%). These arbitrarily defined modulation as a >100% increase >50% decrease of EDs compared baseline, which may not sufficiently distinguish from spontaneous fluctuations. The aim our study assess and...
Summary Autonomic dysfunction is linked to sudden death regardless of the presence structural heart disease. The pathway from autonomic not fully understood, but myocardial sympathetic stimulation leading arrhythmia and/or cardiac fibrosis might play a role. Our goal was evaluate stiffness by echocardiography and its association with clinical, structural, variables in people epilepsy ( PWE ) compared healthy controls. A 12‐lead electrocardiogram, treadmill testing, transthoracic 30 patients...
To investigate prospectively the independent predictors of a minimum clinically important change (MCIC) in quality life (QOL) after anterior temporal lobectomy (ATL) for drug-resistant mesial lobe epilepsy related to hippocampal sclerosis (MTLE-HS) Brazilian patients.Multiple binary logistic regression analysis was performed identify clinical, demographic, radiologic, and electrophysiologic variables independently associated with MCIC Quality Life Epilepsy-31 Inventory (QOLIE-31) overall...
Summary: Clobazam was compared with placebo as an‐tiepileptic adjunct medication in 129 therapy‐resistant epileptic patients who were mainly suffering from complex partial seizures. The study performed five European countries according to a double‐blind crossover design lasting 7 months. Two treatment periods of 3 months (1 month adjustment and 2 maintenance medication) separated by one switch‐over month. difference seizure reduction between clobazam significant (p < 0.05). Nineteen...
Tonic seizures and the tonic phase of tonic-clonic epileptic are defined as "sustained tonic" muscle contraction lasting a few seconds to minutes. Visual inspection surface electromyogram (EMG) during contributed considerably better understanding accurate diagnosis several seizure types. However, quantitative analysis EMG has received surprisingly little attention until now. The aim our study was elucidate pathomechanism activation seizures.Surface recorded from deltoid muscles, on both...
To gain new insights into the clinical presentation, causes, treatment and prognosis of epilepsia partialis continua (EPC), to develop hypotheses be tested in a prospective investigation.In this retrospective multicenter study, all cases were included that fulfilled these criteria: constantly repeated fragments epileptic seizures, with preserved consciousness, lasting ≥ 1 h representing locally restricted motor or sensory activity. Single episodes when they lasted for minimum day. EPC...
Summary Objective To investigate the characteristics of sustained muscle activation during convulsive epileptic and psychogenic nonepileptic seizures ( PNES ), as compared to voluntary activation. The main goal was find surface electromyography EMG ) features that can distinguish between . Methods In this case–control study, recorded from deltoid muscles long‐term video–electroencephalography EEG) monitoring in 25 patients 21 healthy controls. A total 46 clinical episodes were recorded: 28...