A5061821367- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neural Engineering
- Autism Spectrum Disorder Research
- Transcranial Magnetic Stimulation Studies
- Restless Legs Syndrome Research
- Obsessive-Compulsive Spectrum Disorders
- Parkinson's Disease and Spinal Disorders
- Glycogen Storage Diseases and Myoclonus
- Olfactory and Sensory Function Studies
- Neurological diseases and metabolism
- Cerebral Palsy and Movement Disorders
- Attention Deficit Hyperactivity Disorder
- Balance, Gait, and Falls Prevention
- Neurological and metabolic disorders
- Autoimmune Neurological Disorders and Treatments
- Salivary Gland Disorders and Functions
- Acute Ischemic Stroke Management
- Nuclear Receptors and Signaling
- Photoreceptor and optogenetics research
- Ophthalmology and Eye Disorders
- Biochemical Analysis and Sensing Techniques
- Neurogenetic and Muscular Disorders Research
Tecnológico de Monterrey
2012-2025
University of Florida
2013-2019
Florida College
2014-2019
John Wiley & Sons (United States)
2018
Neurology, Inc
2017
Centre for Movement Disorders
2016-2017
University of Florida Health
2016
Instituto Nacional de Neurología y Neurocirugía
2013-2014
Heriot-Watt University
2014
Collective evidence has strongly suggested that deep brain stimulation (DBS) is a promising therapy for Tourette syndrome.To assess the efficacy and safety of DBS in multinational cohort patients with syndrome.The prospective International Deep Brain Stimulation Database Registry included 185 medically refractory syndrome who underwent implantation from January 1, 2012, to December 31, 2016, at 31 institutions 10 countries worldwide.Patients symptoms received centromedian thalamic region (93...
Multispectral light detection and ranging (LiDAR) has the potential to recover structural physiological data from arboreal samples and, by extension, forest canopies when deployed on aerial or space platforms. In this paper, we describe design evaluation of a prototype multispectral LiDAR system demonstrate measurement leaf bark area abundance profiles using series experiments tree "viewed above" tilting living conifers such that apex is directed viewing axis. As complete recovery all...
Deep brain stimulation (DBS) has emerged as a promising intervention for the treatment of select movement and neuropsychiatric disorders. Current DBS therapies deliver electrical continuously are not designed to adapt patient’s symptoms. Continuous can lead rapid battery depletion, which necessitates frequent surgery replacement. Next-generation neurostimulation devices monitor neural signals from implanted leads, where be delivered responsively, moving field neuromodulation away continuous...
Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple motor and vocal tics. Deep brain stimulation (DBS) an emerging therapy for severe cases of TS. We studied two patients with TS implanted bilateral Medtronic Activa PC + S DBS devices, capable chronic recordings, depth leads in the thalamic centromedian–parafascicular complex (CM-PF) subdural strips over precentral gyrus. Low-frequency (1–10 Hz) CM-PF activity was observed during tics, as well modulations beta...
Evidence suggests that nonconventional programming may improve deep brain stimulation (DBS) therapy for movement disorders. The primary objective was to assess feasibility of testing the tolerability several settings in Parkinson's disease (PD) and essential tremor (ET) subjects a single office visit. Secondary objectives were explore potential efficacy signals energy demand on implantable pulse-generators (IPGs). A custom firmware (FW) application developed acutely uploaded IPGs eight PD...
The ventral intermediate nucleus (VIM) is the target of choice for Essential Tremor (ET) deep brain stimulation (DBS). Renewed interest in caudal zona incerta (cZI) tremor control has recently emerged and some groups believe this approach may address long-term reduction benefit seen with VIM-DBS.To compare clinical outcomes DBS programming between VIM cZI neurostimulation ET-DBS patients.A retrospective review 53 leads from 47 patients was performed. Patients were classified into or...
Background Parkinson's disease patients are more likely to be hospitalized, have higher rates of hospital complications, and an increased risk deterioration during hospitalization. Length stay is important underlying factor for these risks. We aimed investigate potential medication errors that may occur hospitalization its impact on length stay. Methods A cross-sectional chart review 339 consecutive encounters from 212 PD subjects was performed. Medication were defined as wrong timing or...
Background Patients with Parkinson disease (PD) are at high risk of hospital encounters increasing morbidity and mortality. This study aimed to determine the rate in a cohort followed over 5 years identify associated factors. Methods We queried data from International Multicenter National Foundation Quality Improvement study. Multivariate logistic regression backward selection was performed factors encounter prior baseline visit. Kaplan-Meier estimates were obtained Cox on time after Results...
Background : Treating medication-refractory freezing of gait (FoG) in Parkinson’s disease (PD) remains challenging despite several trials reporting improvements motor symptoms using subthalamic nucleus or globus pallidus internus (GPi) deep brain stimulation (DBS). Pedunculopontine (PPN) region DBS has been used for FoG, with mixed findings. as a paroxysmal phenomenon, provides an ideal framework the possibility closed-loop (CL-DBS). Methods In this clinical trial (NCT02318927), five...
Deep brain stimulation (DBS) is considered a safe and well tolerated surgical procedure to alleviate Parkinson's disease (PD) other movement disorders symptoms along with some psychiatric conditions. Over the last few decades DBS has been shown provide remarkable therapeutic effect on carefully selected patients. Although its precise mechanism of action still unknown, improves motor functions therefore quality life. To date, two main targets have emerged in PD patients: globus pallidus pars...
Age and sex are known risk factors for Parkinson's Disease (PD), but it remains controversial if there differences in the diagnosis latency. The objective of this study was to examine these Latin America. American Research Consortium on Genetics PD (LARGE-PD) includes patients from countries across America who were diagnosed using UK Brain Bank criteria. Ages at onset (AAO; N = 2,792), (AAD; 1,416), calculated latency (N 1,416) extracted LARGE-PD database compared both males females overall,...
Aspiration pneumonia is an important cause of morbidity and mortality in Parkinson's disease (PD). Clinical characteristics PD patients addition to specific alterations swallowing mechanisms contribute higher times impairment the effective clearance airway. These issues may render more prone dysphagia aspiration events. We aimed determine frequency events a hospitalized cohort, report number in-hospital swallow evaluations. A retrospective single center chart review 212 who had 339 hospital...
Sleep disturbance is a common nonmotor phenomenon in Parkinson's disease (PD) affecting patient's quality of life. In this study, we examined the association between clinical characteristics with sleep disorders and architecture patterns PD cohort. Patients underwent standardized polysomnography study (PSG) their "on medication" state. We observed that male gender duration were independently associated obstructive apnea (OSA). Only lower levodopa equivalent dose (LED) was periodic limb...
Abstract Background The objective of this study was to compare the incidence and prevalence depressive symptoms in atypical parkinsonian ( APD ) syndromes versus Parkinson disease PD ). Methods In a large, retrospective patient cohort, authors analyzed using Beck Depression Inventory evaluated patients longitudinally on subsequent visits. For individuals who were followed at visits, rates calculated person‐years as measure incidence. Results total, 361 identified had syndromes, including...