A5047721445- Treatment of Major Depression
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Genetic Neurodegenerative Diseases
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Exercise and Physiological Responses
- Bipolar Disorder and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Biochemical effects in animals
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Glycation End Products research
- Natural product bioactivities and synthesis
- Trace Elements in Health
- Morinda citrifolia extract uses
- Adenosine and Purinergic Signaling
- Medicinal Plants and Neuroprotection
- Diet and metabolism studies
- Medicinal Plant Extracts Effects
- Nerve injury and regeneration
- Heme Oxygenase-1 and Carbon Monoxide
- Olfactory and Sensory Function Studies
Universidade Federal de Santa Catarina
2013-2022
Universidade Federal de Juiz de Fora
2022
Universidad Autónoma de Madrid
2013-2014
Universidade Federal da Bahia
1994-1997
The relationship between depression and monoaminergic systems has been hypothesized for many years. In this study, we have investigated the possible antidepressant-like effect of scopoletin, a coumarin from Polygala sabulosa in tail suspension test forced swimming test. Moreover, ability scopoletin to reverse depression-like behavior induced by immobility stress mice was evaluated. Scopoletin reduced time (10-100mg/kg, p.o.), but not Fluoxetine (positive control) decreased tests (20mg/kg,...
The aim of this study was to investigate the antidepressant-like effect fractions from Rosmarinus officinalis L.: ethyl acetate 1 and 2 (AcOEt1 2), hexane (HEX), ethanolic (ET), essential oil-free (EOF) fractions, as well oil, isolated compounds carnosol betulinic acid in tail suspension test, a predictive test antidepressant activity. Swiss mice were acutely administered by oral route (p.o.) with oil or compounds, 60 min before open-field test. All them produced significant effect: AcOEt1,...
Ursolic acid, a constituent from Rosmarinus officinalis, is triterpenoid compound which has been extensively known for its anticancer and antioxidant properties. In the present study, we investigated antidepressant-like effect of ursolic acid isolated this plant in two predictive tests antidepressant property, tail suspension test (TST) forced swimming (FST) mice. Furthermore, involvement dopaminergic system was TST. reduced immobility time TST (0.01 0.1 mg/kg, p.o.) FST (10 p.o.), similar...
Cognitive deficits and psychiatric disorders are significant sequelae of traumatic brain injury (TBI). Animal models have been widely employed in TBI research, but few studies addressed the effects experimental different severities on emotional cognitive parameters. In this study, mice were subjected to weight-drop induce mild, intermediate, or severe TBI. After neurological assessment, recovered for 10 days, then a battery behavioral tests, which included open-field, elevated plus-maze,...
The olfactory bulbectomy (OB) is an animal model of depression that results in behavioral, neurochemical and neuroendocrinological changes, features comparable to those seen depressive patients. This study investigated OB-induced alterations locomotor activity exploratory behavior the open-field test, self-care motivational splash hyperactivity novel object test cage influence chronic treatment with fluoxetine (10mg/kg, p.o., once daily for 14days) on these parameters. Fluoxetine reversed...
Rosemary, Rosmarinus officinalis L., has several therapeutic applications in folk medicine for the treatment of a wide range diseases, including depression.To evaluate ability hydroalcoholic extract (ROHE), as compared to positive control fluoxetine, reverse behavioral (hyperactivity, anhedonic behavior and learning deficit water maze) biochemical alterations (serum glucose level acetylcholinesterase, AChE, activity) induced by an animal model depression, olfactory bulbectomy (OB)...
Evidence has indicated that the practice of physical exercise antidepressant effects might be associated with irisin release and BDNF signaling. In this study we investigated central administration or in predictive tests properties paralleled gene expression peroxisome proliferator-activated receptor gamma co-activator 1α (PGC-1α), fibronectin type III domain-containing protein 5 (FNDC5) brain-derived neurotrophic factor (BDNF) hippocampus prefrontal cortex mice. Irisin (0.5–1 ng/mouse,...
Ursolic acid is a pentacyclic triterpenoid that possesses several biological and neuropharmacological effects including antidepressant-like activity. Anxiety disorders represent common disability psychiatric conditions are often associated with depressive symptoms. This work investigated the anxiolytic-like of ursolic administration in different behavioral paradigms evaluate anxiety mice: open field test, elevated plus maze light/dark box test marble burying test. To this end, mice were...
Ursolic acid (UA) is a natural pentacyclic triterpenoid carboxylic that exerts antidepressant-like effects in the tail suspension test (TST) and forced swimming test, this effect was reported to be mediated by dopaminergic system. Many studies show currently available antidepressant agents have on multiple neurotransmitter systems which account for their efficacy. Therefore, study aimed at investigating possible involvement of serotonergic, noradrenergic, glutamatergic opioid UA. To end,...