A5074131420- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Treatment of Major Depression
- Neurotransmitter Receptor Influence on Behavior
- Adenosine and Purinergic Signaling
- Autism Spectrum Disorder Research
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Neuroprotection
- Medicinal Plant Extracts Effects
- Genetic Neurodegenerative Diseases
- Essential Oils and Antimicrobial Activity
- Phytochemistry Medicinal Plant Applications
- Biochemical effects in animals
- Calcium signaling and nucleotide metabolism
- Bipolar Disorder and Treatment
- Olfactory and Sensory Function Studies
- Nerve injury and regeneration
- Memory and Neural Mechanisms
- Epigenetics and DNA Methylation
- Natural Compound Pharmacology Studies
- Nuclear Receptors and Signaling
University of Victoria
2016-2024
Deleted Institution
2023
National Institute of Neurological Disorders and Stroke
2023
Universidade Federal de Santa Catarina
2012-2022
The aim of this study was to investigate the antidepressant-like effect fractions from Rosmarinus officinalis L.: ethyl acetate 1 and 2 (AcOEt1 2), hexane (HEX), ethanolic (ET), essential oil-free (EOF) fractions, as well oil, isolated compounds carnosol betulinic acid in tail suspension test, a predictive test antidepressant activity. Swiss mice were acutely administered by oral route (p.o.) with oil or compounds, 60 min before open-field test. All them produced significant effect: AcOEt1,...
Agmatine has been recently emerged as a novel candidate to assist the conventional pharmacotherapy of depression. The acute restraint stress (ARS) is an unavoidable situation that may cause depressive-like behavior in rodents. In this study, we investigated potential antidepressant-like effect agmatine (10mg/kg, administered acutely by oral route) forced swimming test (FST) non-stressed mice, well its ability abolish and hippocampal antioxidant imbalance induced ARS. reduced immobility time...
The olfactory bulbectomy (OB) is an animal model of depression that results in behavioral, neurochemical and neuroendocrinological changes, features comparable to those seen depressive patients. This study investigated OB-induced alterations locomotor activity exploratory behavior the open-field test, self-care motivational splash hyperactivity novel object test cage influence chronic treatment with fluoxetine (10mg/kg, p.o., once daily for 14days) on these parameters. Fluoxetine reversed...
Rosemary, Rosmarinus officinalis L., has several therapeutic applications in folk medicine for the treatment of a wide range diseases, including depression.To evaluate ability hydroalcoholic extract (ROHE), as compared to positive control fluoxetine, reverse behavioral (hyperactivity, anhedonic behavior and learning deficit water maze) biochemical alterations (serum glucose level acetylcholinesterase, AChE, activity) induced by an animal model depression, olfactory bulbectomy (OB)...
Guanosine is a guanine-based purine that modulates glutamate uptake and exerts neurotrophic neuroprotective effects. In previous study, our group demonstrated this endogenous nucleoside displays antidepressant-like properties in predictive animal model. Based on the role of oxidative stress modulating depressive disorders as well association between antioxidant guanosine, here we investigated if its effect accompanied by modulation hippocampal oxidant/antioxidant parameters. Adult Swiss mice...
Agmatine is an endogenous neuromodulator that has been shown to have antidepressant-like properties. We previously demonstrated it can induce a rapid increase in BDNF levels after acute administration, suggesting agmatine may be fast-acting antidepressant. To investigate this hypothesis, the present study evaluated effects of single administration mice subjected chronic unpredictable stress (CUS), model depression responsive only treatment with conventional antidepressants. The ability...
Several species of Eugenia L. are used in folk medicine for the treatment various diseases. brasiliensis is inflammatory diseases, whereas Eugenia. uniflora symptoms related to depression and mood disorders, Brazil by Guarani Indians as a tonic stimulant.To investigate antidepressant-like effect hydroalcoholic extracts different plant genus characterize participation monoaminergic systems mechanism action specie that afforded most prominent efficacy.In first set experiments, effects...
Purpose Physical activity is currently being considered an effective alternative in the treatment of depression. At preclinical level, voluntary running wheel a useful method increasing physical rodents and induces antidepressant-like effect some behavioral paradigms. Methods This study investigated on mice submitted to forced swimming test (FST) tail suspension test, two predictive tests antidepressant properties. Moreover, influence inhibition serotonin noradrenaline synthesis as well...
Creatine has been shown to play a significant role in health and disease. However, studies concerning its effect on mood are scarce. This study investigated the of creatine (p.o.) tail suspension test, predictive test antidepressant activity. reduced immobility time (0.1–1000 mg/kg, male female mice), without affecting locomotor Furthermore, involvement dopaminergic system creatine-induced antidepressant-like mice was investigated. The anti-immobility (1 mg/kg) prevented by pre-treatment...
Guanosine is a purine nucleoside that occurs naturally in the central nervous system, exerting trophic effects. Given its neuroprotective properties, potential of guanosine as an antidepressant has been recently examined. Within this context, present study sought to investigate effects chronic treatment with on tail suspension test (TST), open field and adult hippocampal neurogenesis. Swiss mice were administered for 21 days (5 mg/kg/day, p.o.) subsequently submitted TST open-field test....
The antidepressant-like activity of creatine in the tail suspension test (TST) was demonstrated previously by our group. In this study we investigated involvement noradrenergic system effect mouse TST. first set experiments, administered i.c.v. route (1 μg/site) decreased immobility time TST, suggesting central compound. anti-immobility peripheral administration mg/kg, p.o.) prevented pretreatment mice with α-methyl-p-tyrosine (100 i.p., inhibitor tyrosine hydroxylase), prazosin...