A5008032272- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- COVID-19 Clinical Research Studies
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Biochemical Analysis and Sensing Techniques
- Cholinesterase and Neurodegenerative Diseases
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- SARS-CoV-2 and COVID-19 Research
- Medicinal Plants and Neuroprotection
- S100 Proteins and Annexins
- Anesthesia and Neurotoxicity Research
- Metabolism and Genetic Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Renin-Angiotensin System Studies
- Nanoparticles: synthesis and applications
- Ion channel regulation and function
- Birth, Development, and Health
Colorado State University
2005-2024
Universidad Nacional de Córdoba
2014-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2012-2023
Centro Científico Tecnológico - San Luis
2022
Hospital Posadas
2021
Pfizer (Spain)
2010
Rosalind Franklin University of Medicine and Science
2006
University of Miami
1999
University of Michigan
1980
Photoinduced antibacterial gold nanoparticles were developed as an alternative for the treatment of antibiotic-resistant bacteria. Thanks to amoxicillin coating, they possess high in vivo stability, selectivity bacteria wall, a good renal clearance, and are completely nontoxic eukaryotic cells at bactericidal concentrations. A simple one-step synthesis amoxi@AuNP is described mild temperatures using antibiotic both reducing stabilizing agent. Time-resolved fluorescence microscopy proved...
Titanium dioxide nanoparticles are widely used in cosmetics, especially sunscreens due to their capacity absorb UV harmful wavelengths. However, biocompatibility remains controversial. In this work, the effect of titanium nanoparticles, particularly Degussa P25 (P25TiO2NPs) under solar-simulated radiation was studied vitro and vivo. Cell viability tissue integrity were affected after exposure P25TiO2NPs light for 6 h, showing signs significant oxidative stress markers reduced observed by...
The nucleus accumbens (NAc) is a forebrain area in the mesocorticolimbic dopamine (DA) system that regulates many aspects of drug addiction. Neuronal activity NAc modulated by different subtypes DA receptors. Although signaling has received considerable attention, mechanisms underlying D(2)-class receptor (D(2)R) modulation firing medium spiny neurons (MSNs) localized within remain ambiguous. In present study, we performed whole cell current-clamp recordings rat brain slices to determine...
BackgroundPerhaps reflecting that children with COVID-19 rarely exhibit severe respiratory symptoms and often remain asymptomatic, little attention has been paid to explore the immune response in pediatric COVID-19. Here, we analyzed phenotype function of circulating neutrophils from COVID-19.MethodsAn observational study including 182 COVID-19, 21 multisystem inflammatory syndrome (MIS-C), 40 healthy was performed Buenos Aires, Argentina. Neutrophil by flow cytometry blood samples. Cytokine...
Traumatic Brain Injury (TBI) remains a leading cause of morbidity and mortality in adults under 40 years old. Once primary injury occurs after TBI, neuroinflammation oxidative stress (OS) are triggered, contributing to the development many TBI-induced neurological deficits, reducing probability critical trauma patients´ survival. Regardless research investment on anti-inflammatory neuroprotective treatments, most pre-clinical studies have failed report significant effects, probably because...
BackgroundMost children and youth develop mild or asymptomatic disease during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, a very small number of patients suffer Coronavirus induced 2019 (COVID-19). The reasons underlying these different outcomes remain unknown.MethodsWe analyzed three cohorts: with infection (n=550), convalescent (n=138), MIS-C (multisystem inflammatory in children, n=42). IgG IgM antibodies to the spike protein SARS-CoV-2,...
Abstract The nucleus accumbens (NAc) is a limbic structure in the forebrain that plays critical role cognitive function and addiction. Dopamine modulates activity of medium spiny neurons (MSNs) NAc. Both dopamine D 1 ‐like 2 receptors (including D1R or 1,5 R D2R 2,3,4 R, respectively) are thought to play roles cocaine Our previous studies demonstrated repeated exposure (which alters transmission) decreases excitability NAc MSNs cocaine‐sensitized, withdrawn rats. This decrease characterized...
Hippocampus is a limbic structure that participates in learning and memory formation. Specifically the dentate gyrus has been described as hippocampal subregion with high rates of plasticity it targeted by different psychoactive drugs modulating synaptic plasticity. Repeated cocaine administration induces sensitization to locomotor effects believed involves same mechanisms drug seeking relapse. Although, underlying not fully understood. In this work we investigated impact repeated...
Neopterin is found at increased levels in biological fluids from individuals with inflammatory disorders. The role of this pteridine remains undefined; however, due to its capacity increase hemeoxygenase-1 content, it has been proposed as a protective agent during cellular stress. Therefore, we investigated the effects neopterin on motor, emotional and memory functions. To address question, (0.4 and/or 4pmol) was injected intracerebroventricularly before or after training sessions step-down...
Cognitive dysfunction is one of the most severe nonmotor symptoms nigrostriatal impairment. This occurs as a result profound functional and morphological changes different neuronal circuits, including modifications in plasticity architecture hippocampal synapses. Such alterations can be implicated genesis progression dementia associated with neurodegenerative diseases Parkinson-like symptoms. There are few studies regarding cognitive animal models. The aim this study was to characterize...