A5072850695- Receptor Mechanisms and Signaling
- Renin-Angiotensin System Studies
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Apelin-related biomedical research
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Cardiac Imaging and Diagnostics
- Anesthesia and Neurotoxicity Research
- Olfactory and Sensory Function Studies
- Diet, Metabolism, and Disease
- Biochemical effects in animals
- Cardiovascular Disease and Adiposity
- Pain Mechanisms and Treatments
- Regulation of Appetite and Obesity
- Cardiovascular Function and Risk Factors
- Helicobacter pylori-related gastroenterology studies
- Sodium Intake and Health
- Plant and animal studies
Universidad Nacional de Córdoba
2015-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2015-2025
Universidad Católica de Córdoba
2013-2024
Universidad Nacional de Cuyo
2007
National Institute of Mental Health
2003-2005
National Institutes of Health
2003-2005
University of Palermo
2001
Stress reduces gastric blood flow and produces acute mucosal lesions. We studied the role of angiotensin II in ulceration during stress. Spontaneously hypertensive rats were pretreated for 14 days with AT1 receptor antagonist candesartan before cold-restraint receptors localized endothelium arteries mucosa all layers. blockade increased by 40-50%, prevented ulcer formation 70-80% after stress, reduced increase adrenomedullary epinephrine tyrosine hydroxylase mRNA without preventing...
Angiotensin II, is critical in regulating the sympathetic and neuroendocrine systems through angiotensin II type 1 receptors (AT1-R). intracerebral administration increases water sodium intake, as well renal excretion. Previously, our group has shown that AT1-R involved behavioral neurochemical sensitization induced by amphetamine. We aimed to assess physiological output, behavioral, responses administration, via AT1-R, twenty-one days after amphetamine administration. Male Wistar rats...
Central nucleus of the amygdala (CeA) is one most important regulatory centres for emotional processes. Among different neurotransmitter systems present in this nucleus, AT 1 receptors have been also found, but their role generation and modulation emotions not fully understood. The work evaluated effect intra-amygdalar injection losartan (AT receptor antagonist) angiotensin II (Ang II) anxiety state induced by fear-potentiated plus maze male Wistar rats. Fear elevated can be potentiated...
Abstract Amphetamine (AMPH) exposure induces behavioural and neurochemical sensitization observed in rodents as hyperlocomotion increased dopamine release response to a subsequent dose. Brain Angiotensin II modulates dopaminergic neurotransmission through its AT 1 receptors (AT ‐R), positively regulating striatal synthesis release. This work aims evaluate the ‐R role development maintenance of AMPH‐induced sensitization. Also, involvement reuptake was analysed. The protocol consisted daily...
The sympathoadrenal response to stress includes a profound increase in adrenomedullary catecholamine synthesis driven by stimulation of tyrosine hydroxylase (TH) transcription. We studied the role Angiotensin II type 1 and 2 (AT(1) AT(2)) receptors during isolation stress, under basal conditions. Pretreatment rats with AT(1) receptor antagonist candesartan for 14 days prior completely prevented stress-induced synthesis, decreasing transcription preventing expression transcriptional factor,...
Background: Amphetamine (AMPH) alters neurons, glia and microvessels, which affects neurovascular unit coupling, leading to disruption in brain functions such as attention working memory. Oxidative stress plays a crucial role these alterations. The angiotensin type I receptors (AT 1 -R) mediate deleterious effects, oxidative/inflammatory responses, endothelial dysfunction, neuronal oxidative damage, alterations that overlap with those observed from AMPH exposure. Aims: aim of this study was...
A bstract : Cold‐restraint stress reduces gastric blood flow and produces acute ulcers. We studied the role of Angiotensin II (Ang II) on ulceration during stress. Spontaneously hypertensive rats, a stress‐sensitive strain, were pretreated for 14 days with AT 1 receptor antagonist candesartan before cold‐restraint blockade increased 40% to 50%; prevented ulcer formation by 70% 80%; reduced increase in adrenomedullary epinephrine TH mRNA without preventing stress‐induced adrenal...
Abstract Amphetamine‐induced neuroadaptations involve vascular damage, neuroinflammation, a hypo‐functioning prefrontal cortex (PFC), and cognitive alterations. Brain angiotensin II, through type 1 receptor (AT ‐R), mediates oxidative/inflammatory responses, promoting endothelial dysfunction, neuronal oxidative damage glial reactivity. The present work aims to unmask the role of AT ‐R in development amphetamine‐induced changes over components within PFC hippocampus. Attention deficit was...
Astrocytes play an essential role in the genesis, maturation and regulation of neurovascular unit. Multiple evidence support that astrocyte reactivity has a close relationship to unit dysfunction, oxidative stress inflammation, providing suitable scenario for development mental disorders. Ketamine been proposed as single-use antidepressant treatment major depression, its effects have associated with anti-inflammatory properties. However, long-lasting over components remain unclear....
Abstract The use of psychostimulants, such as amphetamine (Amph), is associated with inflammatory processes, involving glia and vasculature alterations. Brain Angiotensin II (Ang ), through AT 1 ‐receptors ( ‐R), modulates neurotransmission plays a crucial role in responses brain glia. Our aim for the present work was to evaluate ‐R long‐term alterations induced by repeated exposure Amph. Astrocyte reactivity, neuronal survival microvascular network were analysed at somatosensory cortex....
In previous studies, we have observed that specific N-methyl-d-aspartic acid (NMDA) antagonists and non-NMDA injected within the nucleus accumbens septi (NAS) induced an anxiolytic-like effect in plus maze test rats. present study, of intracanalicular blockade NMDA receptors using dizocilpine was studied male rats bilaterally cannulated NAS.Rats were divided into five groups received either 1 μL injections saline or (MK-801, [5R,10S]-[+]-5-methyl-10,11-dihydro-5H-dibenzo [a,d]...