A5067021327- Receptor Mechanisms and Signaling
- Adenosine and Purinergic Signaling
- Pharmacological Receptor Mechanisms and Effects
- Neuropeptides and Animal Physiology
- Click Chemistry and Applications
- Ion channel regulation and function
Centro de Investigación Biomédica en Red de Salud Mental
2017-2021
Instituto de Salud Carlos III
2021
Universitat Autònoma de Barcelona
2017-2021
Institute of Research and Innovation Parc Tauli
2021
Corporació Sanitària Parc Taulí
2021
Over the past two decades, opioid epidemic in United States and Canada has evidenced need for a better understanding of molecular mechanisms medications used to fight pain. Morphine fentanyl are widely opiate-mediated analgesia treatment chronic These compounds target μ-opioid receptor (MOR), class A G protein-coupled (GPCR). In light described higher efficacy with respect morphine, we have performed independent μs-length unbiased dynamics (MD) simulations MOR complexes each these ligands,...
Tardive dyskinesia (TD) is a serious motor side effect that may appear after long-term treatment with neuroleptics and mostly mediated by dopamine D2 receptors (D2Rs). Striatal D2R functioning be finely regulated either adenosine A2A receptor (A2AR) or angiotensin type 1 (AT1R) through putative heteromers. Here, we examined whether A2AR AT1R oligomerize in the striatum to synergistically modulate dopaminergic transmission. First, using bioluminescence resonance energy transfer, demonstrated...