A5052552737- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Karst Systems and Hydrogeology
- Geological and Geophysical Studies Worldwide
- Asthma and respiratory diseases
- Histone Deacetylase Inhibitors Research
- Occupational and environmental lung diseases
- RNA modifications and cancer
- Chronic Lymphocytic Leukemia Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Geological formations and processes
- African Studies and Geopolitics
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Geology and Paleoclimatology Research
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Respiratory and Cough-Related Research
- Pleural and Pulmonary Diseases
- Immune Cell Function and Interaction
- Paleontology and Stratigraphy of Fossils
- Cancer Research and Treatments
University of Liège
2015-2024
Gembloux Agro-Bio Tech
2015-2024
Leiden University Medical Center
2010-2024
Ghent University
2018-2023
Laboratoire de Géographie Physique
1993-2023
Lanzhou Veterinary Research Institute
2021
Fund for Scientific Research
2007-2018
Global Virus Network
2016-2017
AgroBio
2013-2017
Haga Hospital
2008
According to international guidelines, the level and adjustment of antiinflammatory treatment for asthma are based solely on symptoms lung function. We investigated whether a strategy aimed at reducing airway hyperresponsiveness (AHR strategy) in addition recommendations existing guidelines (reference led to: (1) more effective control asthma; (2) greater improvement chronic airways inflammation. To accomplish this, we conducted randomized, prospective, parallel trial involving 75 adults...
BACKGROUND: Current guidelines on the management of asthma advocate use anti-inflammatory treatment in all but mild disease. They define disease control terms clinical criteria such as lung function and symptoms. However, relationship between inflammation airways is not clear. A cross sectional study was therefore undertaken to investigate measures bronchial hyperresponsiveness asthmatic patients treated with inhaled steroids. METHODS: Twenty six atopic adults (19-45 years) moderate...
DNA methylation is an important epigenetic modification involved in chromatin organization and gene expression. The function of depends on cell context correlated with histone patterns. In particular, trimethylation Lys36 H3 tail (H3K36me3) associated elongation phase transcription. PWWP domains the de novo methyltransferases DNMT3A DNMT3B read this mark to guide methylation. Here we report first crystal structure domain–H3K36me3 complex. Based structure, propose a model complex build...
Abstract Understanding the mechanisms of coronavirus disease 2019 (COVID-19) severity to efficiently design therapies for emerging virus variants remains an urgent challenge ongoing pandemic. Infection and immune reactions are mediated by direct contacts between viral molecules host proteome, vast majority these virus–host (the ‘contactome’) have not been identified. Here, we present a systematic contactome map severe acute respiratory syndrome 2 (SARS-CoV-2) with human encompassing more...
Abstract Comprehensive understanding of the human protein-protein interaction (PPI) network, aka interactome, can provide important insights into molecular mechanisms complex biological processes and diseases. Despite remarkable experimental efforts undertaken to date determine structure many PPIs remain unmapped. Computational approaches, especially network-based methods, facilitate identification previously uncharacterized PPIs. Many such methods have been proposed. Yet, a systematic...
Summary Background Induced sputum potentially allows monitoring of airway inflammation in patients with asthma a non‐invasive way. However, the relationship between cellular content and tissue has not been fully clarified. Objective We compared compositions hypertonic saline‐induced sputum, bronchoalveolar lavage fluid (BAL) bronchial biopsies 18 clinically stable mild to moderate atopic (baseline FEV 1 : range 61–114%pred, PC 20 methacholine: 0.04–4.7 mg/mL). They were treated inhaled...
Rationale: Patients with asthma have an accelerated decline in lung function, which can lead to irreversible airway obstruction. It is generally assumed that this related specific aspects of inflammation and/or remodeling.Objective: We investigated the prognostic significance bronchial eosinophil and CD8+ cell counts subepithelial reticular layer thickness for subsequent function patients after 7.5 years follow-up.Methods: In a prospective study, pre- post-bronchodilator (FEV1) was measured...
A small-cell lung carcinoma (SCLC) is found in 50% of patients with Lambert-Eaton myasthenic syndrome (LEMS). We evaluated screening to optimize strategy for SCLC. It important detect these tumors early newly diagnosed LEMS offer optimal patient treatment.A large nationwide cohort study consecutive the Netherlands, seen between 1990 and 2007, were screened presence a tumor using chest x-ray, computed tomography thorax (CT-thorax), [(18)F]fluorodeoxyglucose positron emission (FDG-PET),...
No treatment is recommended for patients with malignant mesothelioma (MM) failing after first-line cisplatin-based chemotherapy. <i>In vitro</i> data suggested that valproic acid, a histone deacetylase inhibitor (HDACi), had proapoptotic effect and synergised doxorubicin to induce apoptosis in MM cells. Our primary end-point was determine response rate of combined acid unresectable platinum-based Treatment consisted (60 mg·m<sup>-2</sup>) plus acid. An interim analysis planned the first 16...
Deltaretroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia (BLV) induce a persistent infection that remains generally asymptomatic but can also lead to or lymphoma. These viruses replicate by infecting new lymphocytes (i.e. the infectious cycle) via clonal expansion of infected cells (mitotic cycle). The relative importance these two cycles in viral replication varies during infection. majority clones are created early before onset an efficient immune response....
Some plant-associated bacteria such as Bacillus sp. can protect their host from pathogen ingress and this biocontrol activity correlates with potential to form multiple antibiotics upon in vitro growth. However, our knowledge on antibiotic production by soil bacilli evolving roots natural conditions is still limited. In work, antibiome imaging first revealed that the lipopeptide surfactin main bacterial ingredient produced planta within hours of interaction root tissues. We further...
Abstract Most human protein-coding genes are expressed as multiple isoforms, which greatly expands the functional repertoire of encoded proteome. While at least one reliable open reading frame (ORF) model has been assigned for every coding gene, majority alternative isoforms remains uncharacterized due to (i) vast differences overall levels between different from common genes, and (ii) difficulty obtaining full-length transcript sequences. Here, we present ORF Capture-Seq (OCS), a flexible...